| Draft Picks | ||||||
| Overall | Rd | # | Orig Team | Curr Team | # | Player |
| 1 | 1 | 1 | Phi | 2021 Luis Robert | ||
| 2 | 1 | 2 | Cle | 2021 Sixto Sanchez | ||
| 3 | 1 | 3 | Bal | 2021 Ke'Bryan Hayes | ||
| 4 | 1 | 4 | Tex | Atl | 2021 Dylan Carlson | |
| 5 | 1 | 5 | KC | 2021 Brady Singer | ||
| 6 | 1 | 6 | SF | 2021 Ian Anderson | ||
| 7 | 1 | 7 | NYM | 2021 Nate Pearson | ||
| 8 | 1 | 8 | StL | 2021 Alec Bohm | ||
| 9 | 1 | 9 | SD | 2021 Jo Adell | ||
| 10 | 1 | 10 | Pit | 2021 Casey Mize | ||
| 11 | 1 | 11 | LAD | 2021 Andres Gimenez | ||
| 12 | 1 | 12 | Hou | NYM | 2021 Luis Patino | |
| 13 | 1 | 13 | Sea | 2021 Tarik Skubal | ||
| 14 | 1 | 14 | Bos | 2021 Cristian Javier | ||
| 15 | 1 | 15 | Oak | Tex | 2021 Triston McKenzie | |
| 16 | 1 | 16 | Ari | 2021 Joey Bart | ||
| 17 | 1 | 17 | Min | 2021 Daulton Varsho | ||
| 18 | 1 | 18 | Mia | Tex | 2021 Leody Taveras | |
| 19 | 1 | 19 | LAA | Min | 2021 Cristian Pache | |
| 20 | 1 | 20 | ChC | NYY | 2021 Nick Madrigal | |
| 21 | 1 | 21 | TB | 2021 Luis Campusano | ||
| 22 | 1 | 22 | NYY | 2021 Keibert Ruiz | ||
| 23 | 1 | 23 | Was | 2021 Ryan Mountcastle | ||
| 24 | 1 | 24 | Atl | 2021 Kris Bubic | ||
| 25 | 1 | 25 | Tor | NYM | 2021 Spencer Howard | |
| 26 | 1 | 26 | ChW | 2021 Tyler Stephenson | ||
| 27 | 1 | 27 | Det | 2021 Luis Garcia | ||
| 28 | 1 | 28 | Cin | NYM | 2021 Dane Dunning | |
| 29 | 1 | 29 | Mil | Mia | 2021 Deivi Garcia | |
| 30 | 1 | 30 | Col | Oak | 2021 Ryan Jeffers | |
| 31 | 2 | 1 | Phi | 2021 Evan White | ||
| 32 | 2 | 2 | Cle | 2021 Tanner Houck | ||
| 33 | 2 | 3 | Bal | 2021 Alejandro Kirk | ||
| 34 | 2 | 4 | Tex | KC | 2021 Sam Huff | |
| 35 | 2 | 5 | KC | 2021 Trevor Rogers | ||
| 36 | 2 | 6 | SF | 2021 David Peterson | ||
| 37 | 2 | 7 | NYM | Min | 2021 Dean Kremer | |
| 38 | 2 | 8 | StL | 2021 Garrett Crochet | ||
| 39 | 2 | 9 | SD | 2021 Jazz Chisholm | ||
| 40 | 2 | 10 | Pit | 2021 Jose Garcia | ||
| 41 | 2 | 11 | LAD | 2021 Jake Cronenworth | ||
| 42 | 2 | 12 | Hou | Bos | 2021 Kwang Hyun Kim | |
| 43 | 2 | 13 | Sea | 2021 William Contreras | ||
| 44 | 2 | 14 | Bos | Mia | 2021 Josh Fleming | |
| 45 | 2 | 15 | Oak | Phi | 2021 Clarke Schmidt | |
| 46 | 2 | 16 | Ari | 2021 Brailyn Marquez | ||
| 47 | 2 | 17 | Min | 2021 Keegan Akin | ||
| 48 | 2 | 18 | Mia | NYM | 2021 Isaac Paredes | |
| 49 | 2 | 19 | LAA | 2021 Miguel Yajure | ||
| 50 | 2 | 20 | ChC | 2021 Bobby Dalbec | ||
| 51 | 2 | 21 | TB | 2021 Lewin Diaz | ||
| 52 | 2 | 22 | NYY | Mia | 2021 JT Brubaker | |
| 53 | 2 | 23 | Was | 2021 Codi Heuer | ||
| 54 | 2 | 24 | Atl | 2021 Ryan Castellani | ||
| 55 | 2 | 25 | Tor | NYM | 2021 Sherten Apostel | |
| 56 | 2 | 26 | ChW | 2021 Tejay Antone | ||
| 57 | 2 | 27 | Det | 2021 Kyle Cody | ||
| 58 | 2 | 28 | Cin | Cle | 2021 Edward Olivares | |
| 59 | 2 | 29 | Mil | Tex | 2021 Monte Harrison | |
| 60 | 2 | 30 | Col | NYM | 2021 Anderson Tejeda | |
| 61 | 3 | 1 | Phi | |||
| 62 | 3 | 2 | Cle | 2021 Jonathan Arauz | ||
| 63 | 3 | 3 | Bal | 2021 Jesus Sanchez | ||
| 64 | 3 | 4 | Tex | 2021 Wil Crowe | ||
| 65 | 3 | 5 | KC | 2021 Yoshi Tsutsugo | ||
| 66 | 3 | 6 | SF | 2021 Santiago Espinal | ||
| 67 | 3 | 7 | NYM | Min | 2021 Jahmai Jones | |
| 68 | 3 | 8 | StL | 2021 Johan Oviedo | ||
| 69 | 3 | 9 | SD | 2021 Estevan Florial | ||
| 70 | 3 | 10 | Pit | 2021 Luis Garcia | ||
| 71 | 3 | 11 | LAD | 2021 Victor Gonzalez | ||
| 72 | 3 | 12 | Hou | 2021 Jared Oliva | ||
| 73 | 3 | 13 | Sea | Atl | 2021 Pavin Smith | |
| 74 | 3 | 14 | Bos | Cle | 2021 Daniel Castano | |
| 75 | 3 | 15 | Oak | StL | 2021 Ljay Newsome | |
| 76 | 3 | 16 | Ari | 2021 Daulton Jefferies | ||
| 77 | 3 | 17 | Min | ChC | 2021 Shogo Akiyama | |
| 78 | 3 | 18 | Mia | Bos | 2021 Daz Cameron | |
| 79 | 3 | 19 | LAA | 2021 Daniel Johnson | ||
| 80 | 3 | 20 | ChC | Cle | 2021 Brandon Bielak | |
| 81 | 3 | 21 | TB | 2021 Braxton Garrett | ||
| 82 | 3 | 22 | NYY | Cle | 2021 Ramon Urias | |
| 83 | 3 | 23 | Was | 2021 Matt Foster | ||
| 84 | 3 | 24 | Atl | ChW | 2021 Blake Taylor | |
| 85 | 3 | 25 | Tor | NYM | 2021 Thomas Hatch | |
| 86 | 3 | 26 | ChW | 2021 Vimael Machin | ||
| 87 | 3 | 27 | Det | 2021 Caleb Baragar | ||
| 88 | 3 | 28 | Cin | |||
| 89 | 3 | 29 | Mil | 2021 Zach McKinstry | ||
| 90 | 3 | 30 | Col | 2021 Kyle Finnegan | ||
| 91 | 4 | 1 | Phi | Oak | 2021 Mickey Moniak | |
| 92 | 4 | 2 | Cle | |||
| 93 | 4 | 3 | Bal | 2021 Nick Nelson | ||
| 94 | 4 | 4 | Tex | Mia | 2021 Jose Marmolejos | |
| 95 | 4 | 5 | KC | 2021 Yohan Ramirez | ||
| 96 | 4 | 6 | SF | 2021 Eli White | ||
| 97 | 4 | 7 | NYM | Was | 2021 Brent Rooker | |
| 98 | 4 | 8 | StL | 2021 Jonah Heim | ||
| 99 | 4 | 9 | SD | |||
| 100 | 4 | 10 | Pit | 2021 Jake Woodford | ||
| 101 | 4 | 11 | LAD | 2021 Wyatt Mathisen | ||
| 102 | 4 | 12 | Hou | Bos | 2021 Chadwick Tromp | |
| 103 | 4 | 13 | Sea | NYY | 2021 Cody Ponce | |
| 104 | 4 | 14 | Bos | Cle | 2021 Rafael Marchan | |
| 105 | 4 | 15 | Oak | 2021 Ryan Thompson | ||
| 106 | 4 | 16 | Ari | 2021 Tucker Davidson | ||
| 107 | 4 | 17 | Min | ChC | 2021 Jonathan Stiever | |
| 108 | 4 | 18 | Mia | NYY | 2021 Jorge Ona | |
| 109 | 4 | 19 | LAA | 2021 Nick Neidert | ||
| 110 | 4 | 20 | ChC | SF | 2021 Derek Hill | |
| 111 | 4 | 21 | TB | 2021 Enoli Paredes | ||
| 112 | 4 | 22 | NYY | 2021 Justin Topa | ||
| 113 | 4 | 23 | Was | 2021 Andre Scrubb | ||
| 114 | 4 | 24 | Atl | |||
| 115 | 4 | 25 | Tor | NYM | 2021 Drew Rasmussen | |
| 116 | 4 | 26 | ChW | 2021 Anthony Misiewicz | ||
| 117 | 4 | 27 | Det | |||
| 118 | 4 | 28 | Cin | NYM | 2021 Demarcus Evans | |
| 119 | 4 | 29 | Mil | 2021 Andy Young | ||
| 120 | 4 | 30 | Col | Bos | 2021 Adonis Medina | |
| 121 | 5 | 1 | Phi | Bos | 2021 Julian Merryweather | |
| 122 | 5 | 2 | Cle | Det | 2021 Jorge Mateo | |
| 123 | 5 | 3 | Bal | 2021 Edwar Colina | ||
| 124 | 5 | 4 | Tex | |||
| 125 | 5 | 5 | KC | 2021 Cam Hill | ||
| 126 | 5 | 6 | SF | 2021 Carlos Hernandez | ||
| 127 | 5 | 7 | NYM | Mia | 2021 Wes Benjamin | |
| 128 | 5 | 8 | StL | 2021 Bruce Zimmermann | ||
| 129 | 5 | 9 | SD | 2021 Franklyn Kilome | ||
| 130 | 5 | 10 | Pit | 2021 Connor Brogdon | ||
| 131 | 5 | 11 | LAD | 2021 Ali Sanchez | ||
| 132 | 5 | 12 | Hou | Mil | 2021 Alex Vesia | |
| 133 | 5 | 13 | Sea | LAA | 2021 Mark Mathias | |
| 134 | 5 | 14 | Bos | 2021 Luis Gonzalez | ||
| 135 | 5 | 15 | Oak | 2021 Jordan Weems | ||
| 136 | 5 | 16 | Ari | 2021 James Kaprielian | ||
| 137 | 5 | 17 | Min | ChC | 2021 Seth Romero | |
| 138 | 5 | 18 | Mia | Tex | 2021 Kodi Whitley | |
| 139 | 5 | 19 | LAA | 2021 Nick Mears | ||
| 140 | 5 | 20 | ChC | 2021 Yermin Mercedes | ||
| 141 | 5 | 21 | TB | 2021 Tyson Miller | ||
| 142 | 5 | 22 | NYY | Cle | 2021 Max Schrock | |
| 143 | 5 | 23 | Was | |||
| 144 | 5 | 24 | Atl | 2021 Tyler Zuber | ||
| 145 | 5 | 25 | Tor | NYM | 2021 John King | |
| 146 | 5 | 26 | ChW | 2021 Ben Braymer | ||
| 147 | 5 | 27 | Det | 2021 Riley Smith | ||
| 148 | 5 | 28 | Cin | |||
| 149 | 5 | 29 | Mil | 2021 Mitch White | ||
| 150 | 5 | 30 | Col | 2021 Humberto Mejia | ||
| 151 | 6 | 1 | Phi | 2021 Joey Gerber | ||
| 152 | 6 | 2 | Cle | Mia | 2021 Sergio Alcantara | |
| 153 | 6 | 3 | Bal | 2021 Brandon Leibrandt | ||
| 154 | 6 | 4 | Tex | 2021 Seth Elledge | ||
| 155 | 6 | 5 | KC | 2021 Ramon Rosso | ||
| 156 | 6 | 6 | SF | ChC | 2021 Travis Blankenhorn | |
| 157 | 6 | 7 | NYM | 2021 Nick Heath | ||
| 158 | 6 | 8 | StL | 2021 Beau Burrows | ||
| 159 | 6 | 9 | SD | NYM | 2021 Albert Abreu | |
| 160 | 6 | 10 | Pit | 2021 Elliot Soto | ||
| 161 | 6 | 11 | LAD | 2021 Taylor Widener | ||
| 162 | 6 | 12 | Hou | 2021 Ashton Goudeau | ||
| 163 | 6 | 13 | Sea | 2021 Luis Alexande Basabe | ||
| 164 | 6 | 14 | Bos | LAA | 2021 JoJo Romero | |
| 165 | 6 | 15 | Oak | 2021 Blake Cederlind | ||
| 166 | 6 | 16 | Ari | 2021 Zack Burdi | ||
| 167 | 6 | 17 | Min | LAA | 2021 Eddy Alvarez | |
| 168 | 6 | 18 | Mia | Col | 2021 Rony Garcia | |
| 169 | 6 | 19 | LAA | 2021 J.P. Feyereisen | ||
| 170 | 6 | 20 | ChC | NYY | 2021 Kyle Hart | |
| 171 | 6 | 21 | TB | 2021 Jimmy Lambert | ||
| 172 | 6 | 22 | NYY | |||
| 173 | 6 | 23 | Was | 2021 Mauricio Llovera | ||
| 174 | 6 | 24 | Atl | 2021 Patrick Murphy | ||
| 175 | 6 | 25 | Tor | NYM | 2021 Taylor Jones | |
| 176 | 6 | 26 | ChW | 2021 Joseph Odom | ||
| 177 | 6 | 27 | Det | |||
| 178 | 6 | 28 | Cin | |||
| 179 | 6 | 29 | Mil | 2021 Jorge Guzman | ||
| 180 | 6 | 30 | Col | |||
| 181 | 7 | 1 | KC | 2021 Brian Navarreto | ||
| 182 | 7 | 2 | SF | 2021 Yadiel Hernandez | ||
| 183 | 7 | 3 | StL | 2021 Nabil Crismatt | ||
| 184 | 7 | 4 | Pit | 2021 Humberto Castellanos | ||
| 185 | 7 | 5 | LAD | 2021 Patrick Weigel | ||
| 186 | 7 | 6 | Hou | 2021 Carlos Sanabria | ||
| 187 | 7 | 7 | Bos | 2021 Rob Kaminsky | ||
| 188 | 7 | 8 | Oak | 2021 Bernardo Flores | ||
| 189 | 7 | 9 | Ari | 2021 Joe McCarthy | ||
| 190 | 7 | 10 | Min | Pit | 2021 Brandon Bailey | |
| 191 | 7 | 11 | Mia | 2021 Sterling Sharp | ||
| 192 | 7 | 19 | LAA | Tex | 2021 Scott Blewett | |
| 193 | 7 | 13 | ChC | 2021 Dany Jimenez | ||
| 194 | 7 | 14 | TB | 2021 Shun Yamaguchi | ||
| 195 | 7 | 15 | Tor | 2021 Tommy Doyle | ||
| 196 | 7 | 16 | ChW | 2021 Foster Griffin | ||
| 197 | 7 | 17 | Mil | 2021 Garrett Cleavinger | ||