Team game results - 2021 Seattle Mariners
Regular season
| Primary |
| Date | # | | Opp | | Score | Inn | Starter | T | W/L | Save | Versus | T |
| 4/15/2021 | | @ | Hou | W | 5-2 | | Minor, M | L | Minor, M | Diekman, J | Walker, T | R |
| 4/15/2021 | | | Tex | W | 5-2 | | Minor, M | L | Minor, M | Diekman, J | McKenzie, T | R |
| 4/16/2021 | | @ | Hou | W | 6-4 | | Glasnow, T | R | Wisler, M | O'Day, D | Dunn, J | R |
| 4/16/2021 | | | Tex | W | 5-4 | | Glasnow, T | R | Glasnow, T | Diekman, J | Thorpe, L | L |
| 4/17/2021 | | @ | Hou | W | 9-3 | 12 | Skubal, T | L | Rodriguez, R | | Hill, R | L |
| 4/17/2021 | | | Tex | L | 2-6 | | Skubal, T | L | Skubal, T | | Eshelman, T | R |
| 4/19/2021 | | @ | Oak | L | 2-4 | | Shoemaker, M | R | Rodriguez, R | | Dobnak, R | R |
| 4/19/2021 | | | LAA | W | 8-1 | | Urquidy, J | R | Urquidy, J | | Darvish, Y | R |
| 4/20/2021 | | @ | Oak | L | 2-10 | | Minor, M | L | Minor, M | | Scherzer, M | R |
| 4/20/2021 | | | LAA | W | 6-3 | | Minor, M | L | Minor, M | | Bumgarner, M | L |
| 4/21/2021 | | @ | Oak | L | 1-7 | | Glasnow, T | R | Glasnow, T | | Cueto, J | R |
| 4/21/2021 | | | LAA | L | 1-3 | | Glasnow, T | R | Glasnow, T | | Boyd, M | L |
| 4/22/2021 | | | Oak | L | 1-2 | | Skubal, T | L | Skubal, T | | Scherzer, M | R |
| 4/22/2021 | | @ | LAA | W | 8-3 | | Skubal, T | L | Smith, B | | Gomber, A | L |
| 4/23/2021 | | | Oak | W | 7-0 | | Fedde, E | R | Fedde, E | | Thompson, R | R |
| 4/23/2021 | | @ | LAA | L | 4-6 | | Wisler, M | R | Wisler, M | | Pineda, M | R |
| 4/24/2021 | | | Oak | W | 3-1 | | Minor, M | L | Minor, M | Diekman, J | Cueto, J | R |
| 4/24/2021 | | @ | LAA | L | 5-6 | | Shoemaker, M | R | Shoemaker, M | | Darvish, Y | R |
| 4/26/2021 | | | Hou | L | 1-2 | | Urquidy, J | R | Watson, T | | Smyly, D | L |
| 4/26/2021 | | @ | Tex | L | 8-11 | | Glasnow, T | R | Watson, T | | Fulmer, M | R |
| 4/27/2021 | | | Hou | W | 6-4 | | Glasnow, T | R | Wisler, M | O'Day, D | Walker, T | R |
| 4/27/2021 | | @ | Tex | W | 8-4 | | Minor, M | L | Minor, M | Wisler, M | Thorpe, L | L |
| 4/28/2021 | | | Hou | W | 5-2 | | Fedde, E | R | Fedde, E | Diekman, J | Dunn, J | R |
| 4/28/2021 | | @ | Tex | W | 11-5 | | Skubal, T | L | Skubal, T | | Sanchez, A | R |
| 5/13/2021 | | | Pit | W | 10-3 | | Skubal, T | L | Skubal, T | | Davies, Z | R |
| 5/13/2021 | | @ | Mia | W | 6-0 | | Shoemaker, M | R | Shoemaker, M | | Eflin, Z | R |
| 5/14/2021 | | | Pit | W | 11-6 | | Minor, M | L | Minor, M | | Montgomery, J | L |
| 5/14/2021 | | @ | Mia | L | 7-13 | | Wisler, M | R | Margevicius, N | | Fleming, J | L |
| 5/15/2021 | | | Pit | W | 12-4 | | Glasnow, T | R | Glasnow, T | | Senzatela, A | R |
| 5/15/2021 | | @ | Mia | W | 2-0 | | Glasnow, T | R | Glasnow, T | Diekman, J | Valdez, F | L |
| 5/17/2021 | | @ | Phi | L | 4-5 | | Urquidy, J | R | O'Day, D | | Manaea, S | L |
| 5/17/2021 | | | ChC | W | 3-1 | | Urquidy, J | R | Urquidy, J | Diekman, J | Greinke, Z | R |
| 5/18/2021 | | @ | Phi | L | 5-10 | | Shoemaker, M | R | Shoemaker, M | | Clevinger, M | R |
| 5/18/2021 | | | ChC | L | 2-7 | | Skubal, T | L | Skubal, T | | Keuchel, D | L |
| 5/19/2021 | | @ | Phi | W | 4-2 | | Wisler, M | R | Margevicius, N | Smith, B | Hernandez, E | R |
| 5/19/2021 | | | ChC | W | 20-7 | | Fedde, E | R | Fedde, E | Margevicius, N | King, M | R |
| 5/21/2021 | | @ | Atl | W | 3-2 | 16 | Glasnow, T | R | O'Day, D | | Corbin, P | L |
| 5/21/2021 | | | Cin | L | 2-15 | | Minor, M | L | Minor, M | | Woodruff, B | R |
| 5/22/2021 | | @ | Atl | L | 7-8 | 16 | Urquidy, J | R | Castro, M | | Bubic, K | L |
| 5/22/2021 | | | Cin | L | 2-5 | 13 | Glasnow, T | R | Diekman, J | | Berrios, J | R |
| 5/23/2021 | | @ | Atl | W | 8-5 | | Shoemaker, M | R | Shoemaker, M | Castro, M | Castellani, R | R |
| 5/23/2021 | | | Cin | W | 4-3 | | Skubal, T | L | Skubal, T | Diekman, J | Kikuchi, Y | L |
| 5/24/2021 | | @ | NYM | W | 3-2 | | Wisler, M | R | Smith, B | | Pearson, N | R |
| 5/24/2021 | | | Mil | L | 3-4 | 10 | Urquidy, J | R | O'Day, D | | Smith, C | L |
| 5/25/2021 | | @ | NYM | W | 7-0 | | Rea, C | R | Rea, C | | Howard, S | R |
| 5/25/2021 | | | Mil | L | 0-6 | | Fedde, E | R | Fedde, E | | Kershaw, C | L |
| 5/26/2021 | | @ | NYM | W | 8-3 | | Glasnow, T | R | Glasnow, T | | Mengden, D | R |
| 5/26/2021 | | | Mil | L | 2-3 | | Minor, M | L | Minor, M | | Brault, S | L |
| 5/28/2021 | | @ | Was | W | 4-2 | | Shoemaker, M | R | Shoemaker, M | Diekman, J | Bassitt, C | R |
| 5/28/2021 | | | StL | W | 5-2 | | Glasnow, T | R | Glasnow, T | O'Day, D | Ray, R | L |
| 5/29/2021 | | @ | Was | L | 3-11 | | Wisler, M | R | Wisler, M | | Gonzales, M | L |
| 5/29/2021 | | | StL | L | 6-9 | | Skubal, T | L | Skubal, T | | Oviedo, J | R |
| 5/30/2021 | | @ | Was | L | 6-9 | | Urquidy, J | R | Urquidy, J | | Buehler, W | R |
| 5/30/2021 | | | StL | L | 5-8 | | Fedde, E | R | Fedde, E | | Newsome, L | R |
| 6/14/2021 | | @ | KC | W | 6-2 | | Minor, M | L | Minor, M | | Rogers, T | L |
| 6/14/2021 | | | Bos | L | 0-7 | | Minor, M | L | Minor, M | | Ynoa, H | R |
| 6/15/2021 | | @ | KC | L | 6-8 | | Wisler, M | R | Wisler, M | | Voth, A | R |
| 6/15/2021 | | | Bos | L | 0-6 | | Glasnow, T | R | Glasnow, T | | Javier, C | R |
| 6/16/2021 | | @ | KC | W | 3-2 | | Fedde, E | R | Fedde, E | Diekman, J | Singer, B | R |
| 6/16/2021 | | | Bos | W | 1-0 | | Skubal, T | L | Fedde, E | O'Day, D | Kim, K | L |
| 6/17/2021 | | @ | ChW | L | 4-8 | | Shoemaker, M | R | Shoemaker, M | | Antone, T | R |
| 6/17/2021 | | | NYY | L | 0-10 | | Urquidy, J | R | Urquidy, J | | May, D | R |
| 6/18/2021 | | @ | ChW | L | 2-3 | | Urquidy, J | R | Urquidy, J | | Freeland, K | L |
| 6/18/2021 | | | NYY | W | 3-1 | | Fedde, E | R | Fedde, E | O'Day, D | Duffy, D | L |
| 6/19/2021 | | @ | ChW | W | 11-7 | | Minor, M | L | Minor, M | | Eovaldi, N | R |
| 6/19/2021 | | | NYY | L | 1-6 | | Minor, M | L | Minor, M | | Lynn, L | R |
| 6/21/2021 | | @ | Min | W | 12-3 | | Wisler, M | R | Margevicius, N | Rea, C | Allard, K | L |
| 6/21/2021 | | | TB | W | 11-6 | | Glasnow, T | R | Wisler, M | | Smeltzer, D | L |
| 6/22/2021 | | @ | Min | L | 5-6 | | Fedde, E | R | Diekman, J | | Musgrove, J | R |
| 6/22/2021 | | | TB | W | 7-4 | | Skubal, T | L | Skubal, T | | Anderson, B | L |
| 6/23/2021 | | @ | Min | W | 5-2 | | Shoemaker, M | R | Shoemaker, M | Rodriguez, R | Mahle, T | R |
| 6/23/2021 | | | TB | W | 15-4 | | Fedde, E | R | Fedde, E | | Lopez, R | R |
| 6/24/2021 | | @ | Cle | W | 6-4 | | Minor, M | L | Minor, M | Diekman, J | Weber, R | R |
| 6/24/2021 | | | Tor | W | 9-4 | | Urquidy, J | R | Urquidy, J | | Velasquez, V | R |
| 6/25/2021 | | @ | Cle | W | 3-2 | 13 | Urquidy, J | R | Watson, T | Castro, M | Civale, A | R |
| 6/25/2021 | | | Tor | W | 6-2 | | Minor, M | L | Minor, M | | Lorenzen, M | R |
| 6/26/2021 | | @ | Cle | W | 2-0 | | Wisler, M | R | Margevicius, N | Smith, B | Keller, B | R |
| 6/26/2021 | | | Tor | W | 6-2 | | Glasnow, T | R | Glasnow, T | | Newcomb, S | L |
| 6/28/2021 | | @ | Det | W | 8-7 | | Fedde, E | R | Castro, M | Watson, T | Lester, J | L |
| 6/28/2021 | | | Bal | L | 5-10 | | Skubal, T | L | Skubal, T | | Cahill, T | R |
| 6/29/2021 | | @ | Det | W | 8-4 | | Minor, M | L | Minor, M | Diekman, J | Flaherty, J | R |
| 6/29/2021 | | | Bal | W | 4-3 | | Fedde, E | R | Watson, T | | Turnbull, S | R |
| 6/30/2021 | | @ | Det | L | 4-7 | | Shoemaker, M | R | Shoemaker, M | | Marquez, G | R |
| 6/30/2021 | | | Bal | L | 2-8 | | Minor, M | L | Minor, M | | Urias, J | L |
| 7/15/2021 | | @ | Oak | L | 1-6 | | Minor, M | L | Minor, M | | Anderson, T | L |
| 7/15/2021 | | | LAA | W | 5-3 | | Minor, M | L | O'Day, D | Diekman, J | Darvish, Y | R |
| 7/16/2021 | | @ | Oak | L | 0-5 | | Glasnow, T | R | Glasnow, T | | Fried, M | L |
| 7/16/2021 | | | LAA | W | 14-4 | | Glasnow, T | R | Glasnow, T | | Toussaint, T | R |
| 7/17/2021 | | @ | Oak | W | 9-0 | | Keller, B | R | Keller, B | | Cueto, J | R |
| 7/17/2021 | | | LAA | L | 2-6 | | Skubal, T | L | Skubal, T | | Bumgarner, M | L |
| 7/19/2021 | | | Hou | W | 11-0 | | Urquidy, J | R | Urquidy, J | | Dunn, J | R |
| 7/19/2021 | | @ | Tex | W | 6-3 | | Fedde, E | R | Fedde, E | Diekman, J | Fulmer, M | R |
| 7/20/2021 | | | Hou | W | 7-2 | | Minor, M | L | Wisler, M | | Gray, J | R |
| 7/20/2021 | | @ | Tex | W | 6-1 | | Minor, M | L | Minor, M | | Stripling, R | R |
| 7/21/2021 | | | Hou | W | 5-1 | | Glasnow, T | R | Glasnow, T | | Walker, T | R |
| 7/21/2021 | | @ | Tex | L | 3-4 | 10 | Glasnow, T | R | Rodriguez, R | | Teheran, J | R |
| 7/22/2021 | | @ | Hou | W | 14-2 | | Keller, B | R | Keller, B | Castro, M | Hill, R | L |
| 7/22/2021 | | | Tex | W | 11-3 | | Skubal, T | L | Skubal, T | | Thorpe, L | L |
| 7/23/2021 | | @ | Hou | W | 6-0 | | Wisler, M | R | Margevicius, N | Smith, B | Dunn, J | R |
| 7/23/2021 | | | Tex | W | 9-8 | | Fedde, E | R | Diekman, J | | Stripling, R | R |
| 7/24/2021 | | @ | Hou | L | 2-3 | | Fedde, E | R | O'Day, D | | Walker, T | R |
| 7/24/2021 | | | Tex | W | 4-0 | | Minor, M | L | Minor, M | | Fulmer, M | R |
| 7/26/2021 | | | Oak | W | 4-2 | | Urquidy, J | R | Urquidy, J | O'Day, D | Fried, M | L |
| 7/26/2021 | | @ | LAA | W | 5-3 | | Minor, M | L | Minor, M | Diekman, J | Boyd, M | L |
| 7/27/2021 | | | Oak | W | 5-2 | | Glasnow, T | R | Glasnow, T | | Cueto, J | R |
| 7/27/2021 | | @ | LAA | L | 6-10 | | Glasnow, T | R | Glasnow, T | | Yarbrough, R | L |
| 7/28/2021 | | | Oak | W | 3-1 | | Fedde, E | R | Wisler, M | Diekman, J | Scherzer, M | R |
| 7/28/2021 | | @ | LAA | W | 4-1 | | Keller, B | R | Keller, B | Diekman, J | Pineda, M | R |
| 8/13/2021 | | @ | Bal | L | 2-3 | | Keller, B | R | O'Day, D | | Turnbull, S | R |
| 8/13/2021 | | | KC | W | 1-0 | 10 | Minor, M | L | O'Day, D | | Lamet, D | R |
| 8/14/2021 | | @ | Bal | W | 7-4 | | Glasnow, T | R | Glasnow, T | Diekman, J | Mills, A | R |
| 8/14/2021 | | | KC | W | 11-4 | | Glasnow, T | R | Glasnow, T | | Voth, A | R |
| 8/15/2021 | | @ | Bal | L | 0-3 | | Fedde, E | R | Fedde, E | | Cobb, A | R |
| 8/15/2021 | | | KC | L | 4-6 | | Skubal, T | L | Skubal, T | | Singer, B | R |
| 8/16/2021 | | | Min | W | 7-1 | | Urquidy, J | R | Urquidy, J | | Mahle, T | R |
| 8/16/2021 | | @ | TB | W | 12-7 | | Wisler, M | R | Rodriguez, R | | Wright, K | R |
| 8/17/2021 | | | Min | W | 3-2 | | Fedde, E | R | Diekman, J | | Allard, K | L |
| 8/17/2021 | | @ | TB | W | 6-3 | | Skubal, T | L | Skubal, T | Diekman, J | Lopez, R | R |
| 8/18/2021 | | | Min | W | 5-1 | | Minor, M | L | Minor, M | | Kremer, D | R |
| 8/18/2021 | | @ | TB | W | 7-0 | | Keller, B | R | Keller, B | | Smeltzer, D | L |
| 8/20/2021 | | | ChW | L | 3-7 | | Glasnow, T | R | Castro, M | | Tanaka, M | R |
| 8/20/2021 | | @ | Tor | W | 21-3 | | Glasnow, T | R | Smith, B | | Brewer, C | R |
| 8/21/2021 | | | ChW | L | 3-5 | | Skubal, T | L | Skubal, T | | Freeland, K | L |
| 8/21/2021 | | @ | Tor | W | 8-4 | | Fedde, E | R | Rodriguez, R | | Clarke, T | R |
| 8/22/2021 | | | ChW | L | 2-3 | | Fedde, E | R | Fedde, E | | Montgomery, M | L |
| 8/22/2021 | | @ | Tor | L | 3-4 | | Wisler, M | R | Margevicius, N | | Newcomb, S | L |
| 8/23/2021 | | @ | Bos | W | 6-2 | | Keller, B | R | Keller, B | | Kim, K | L |
| 8/23/2021 | | | Det | L | 3-4 | | Urquidy, J | R | Urquidy, J | | Bauer, T | R |
| 8/24/2021 | | @ | Bos | W | 5-3 | | Skubal, T | L | Smith, B | O'Day, D | Javier, C | R |
| 8/24/2021 | | | Det | L | 5-6 | | Minor, M | L | Minor, M | | Flaherty, J | R |
| 8/25/2021 | | @ | Bos | W | 7-1 | | Glasnow, T | R | Glasnow, T | | Webb, L | R |
| 8/25/2021 | | | Det | L | 3-4 | | Glasnow, T | R | O'Day, D | | Lester, J | L |
| 8/27/2021 | | @ | NYY | W | 11-1 | | Fedde, E | R | Fedde, E | | Duffy, D | L |
| 8/27/2021 | | | Cle | W | 9-4 | | Skubal, T | L | Skubal, T | | Castano, D | L |
| 8/28/2021 | | @ | NYY | W | 2-0 | | Keller, B | R | Keller, B | Diekman, J | Burnes, C | R |
| 8/28/2021 | | | Cle | W | 4-1 | | Fedde, E | R | Fedde, E | O'Day, D | Shoemaker, M | R |
| 8/29/2021 | | @ | NYY | W | 8-2 | | Margevicius, N | L | Smith, B | | Lynn, L | R |
| 8/29/2021 | | | Cle | W | 6-1 | | Minor, M | L | Minor, M | Diekman, J | Civale, A | R |
| 9/13/2021 | | | Hou | W | 5-2 | | Minor, M | L | Minor, M | O'Day, D | Smyly, D | L |
| 9/13/2021 | | @ | Tex | W | 6-1 | | Minor, M | L | Minor, M | | McKenzie, T | R |
| 9/14/2021 | | | Hou | W | 3-0 | | Glasnow, T | R | Glasnow, T | O'Day, D | Dunn, J | R |
| 9/14/2021 | | @ | Tex | L | 0-3 | | Glasnow, T | R | Glasnow, T | | Eshelman, T | R |
| 9/15/2021 | | | Hou | W | 5-2 | | Skubal, T | L | Wisler, M | Diekman, J | Hill, R | L |
| 9/15/2021 | | @ | Tex | W | 3-2 | | Rea, C | R | Rea, C | Diekman, J | Teheran, J | R |
| 9/17/2021 | | | Oak | W | 7-2 | | Urquidy, J | R | Urquidy, J | | Cueto, J | R |
| 9/17/2021 | | @ | LAA | W | 10-1 | | Skubal, T | L | Skubal, T | | Darvish, Y | R |
| 9/18/2021 | | | Oak | W | 5-3 | | Minor, M | L | Minor, M | Diekman, J | Kuhl, C | R |
| 9/18/2021 | | @ | LAA | L | 3-7 | | Minor, M | L | Rodriguez, R | | Boyd, M | L |
| 9/19/2021 | | | Oak | W | 4-1 | | Glasnow, T | R | Glasnow, T | O'Day, D | Fried, M | L |
| 9/19/2021 | | @ | LAA | L | 1-2 | | Glasnow, T | R | Glasnow, T | | Yarbrough, R | L |
| 9/20/2021 | | @ | Oak | W | 7-1 | | Rea, C | R | Rea, C | Margevicius, N | Scherzer, M | R |
| 9/20/2021 | | | LAA | L | 4-5 | | Skubal, T | L | Skubal, T | | Bumgarner, M | L |
| 9/21/2021 | | @ | Oak | L | 3-8 | | Fedde, E | R | Fedde, E | | Dobnak, R | R |
| 9/21/2021 | | | LAA | W | 4-3 | | Keller, B | R | Keller, B | Diekman, J | Pineda, M | R |
| 9/22/2021 | | @ | Oak | L | 5-6 | | Skubal, T | L | Diekman, J | | Fried, M | L |
| 9/22/2021 | | | LAA | L | 4-6 | | Minor, M | L | Minor, M | | Darvish, Y | R |
| 9/24/2021 | | @ | Hou | W | 4-3 | | Minor, M | L | Watson, T | Diekman, J | Dunn, J | R |
| 9/24/2021 | | | Tex | W | 6-2 | | Urquidy, J | R | Urquidy, J | | Crowe, W | R |
| 9/25/2021 | | @ | Hou | W | 17-6 | | Glasnow, T | R | Wisler, M | | Verlander, J | R |
| 9/25/2021 | | | Tex | W | 4-1 | | Glasnow, T | R | Glasnow, T | Diekman, J | Eshelman, T | R |
| 9/26/2021 | | @ | Hou | L | 4-5 | | Rea, C | R | Rea, C | | Kickham, M | L |
| 9/26/2021 | | | Tex | W | 4-3 | | Keller, B | R | Keller, B | O'Day, D | Teheran, J | R |
| Other |
| | | | | | | | | Cumulative |
| Date | # | | Opp | | GWRBI | RF | RA | W | L | Pct | Last10 | Strk | Gm# |
| 4/15/2021 | | @ | Hou | W | Dickerson, A | 5 | 2 | 1 | 0 | 1.000 | 1-0 | W1 | 1 |
| 4/15/2021 | | | Tex | W | d'Arnaud, T | 5 | 2 | 2 | 0 | 1.000 | 2-0 | W2 | 2 |
| 4/16/2021 | | @ | Hou | W | Dickerson, A | 6 | 4 | 3 | 0 | 1.000 | 3-0 | W3 | 3 |
| 4/16/2021 | | | Tex | W | Cabrera, M | 5 | 4 | 4 | 0 | 1.000 | 4-0 | W4 | 4 |
| 4/17/2021 | | @ | Hou | W | LeMahieu, D | 9 | 3 | 5 | 0 | 1.000 | 5-0 | W5 | 5 |
| 4/17/2021 | | | Tex | L | | 2 | 6 | 5 | 1 | .833 | 5-1 | L1 | 6 |
| 4/19/2021 | | @ | Oak | L | | 2 | 4 | 5 | 2 | .714 | 5-2 | L2 | 7 |
| 4/19/2021 | | | LAA | W | LeMahieu, D | 8 | 1 | 6 | 2 | .750 | 6-2 | W1 | 8 |
| 4/20/2021 | | @ | Oak | L | | 2 | 10 | 6 | 3 | .667 | 6-3 | L1 | 9 |
| 4/20/2021 | | | LAA | W | Happ, I | 6 | 3 | 7 | 3 | .700 | 7-3 | W1 | 10 |
| 4/21/2021 | | @ | Oak | L | | 1 | 7 | 7 | 4 | .636 | 6-4 | L1 | 11 |
| 4/21/2021 | | | LAA | L | | 1 | 3 | 7 | 5 | .583 | 5-5 | L2 | 12 |
| 4/22/2021 | | | Oak | L | | 1 | 2 | 7 | 6 | .538 | 4-6 | L3 | 13 |
| 4/22/2021 | | @ | LAA | W | | 8 | 3 | 8 | 6 | .571 | 4-6 | W1 | 14 |
| 4/23/2021 | | | Oak | W | Happ, I | 7 | 0 | 9 | 6 | .600 | 4-6 | W2 | 15 |
| 4/23/2021 | | @ | LAA | L | | 4 | 6 | 9 | 7 | .563 | 4-6 | L1 | 16 |
| 4/24/2021 | | | Oak | W | Dickerson, A | 3 | 1 | 10 | 7 | .588 | 5-5 | W1 | 17 |
| 4/24/2021 | | @ | LAA | L | | 5 | 6 | 10 | 8 | .556 | 4-6 | L1 | 18 |
| 4/26/2021 | | | Hou | L | | 1 | 2 | 10 | 9 | .526 | 4-6 | L2 | 19 |
| 4/26/2021 | | @ | Tex | L | | 8 | 11 | 10 | 10 | .500 | 3-7 | L3 | 20 |
| 4/27/2021 | | | Hou | W | Merrifield, W | 6 | 4 | 11 | 10 | .524 | 4-6 | W1 | 21 |
| 4/27/2021 | | @ | Tex | W | Engel, A | 8 | 4 | 12 | 10 | .545 | 5-5 | W2 | 22 |
| 4/28/2021 | | | Hou | W | Baez, J | 5 | 2 | 13 | 10 | .565 | 6-4 | W3 | 23 |
| 4/28/2021 | | @ | Tex | W | d'Arnaud, T | 11 | 5 | 14 | 10 | .583 | 6-4 | W4 | 24 |
| 5/13/2021 | | | Pit | W | Arroyo, C | 10 | 3 | 15 | 10 | .600 | 6-4 | W5 | 25 |
| 5/13/2021 | | @ | Mia | W | Dickerson, A | 6 | 0 | 16 | 10 | .615 | 7-3 | W6 | 26 |
| 5/14/2021 | | | Pit | W | Baez, J | 11 | 6 | 17 | 10 | .630 | 7-3 | W7 | 27 |
| 5/14/2021 | | @ | Mia | L | | 7 | 13 | 17 | 11 | .607 | 7-3 | L1 | 28 |
| 5/15/2021 | | | Pit | W | Dickerson, A | 12 | 4 | 18 | 11 | .621 | 8-2 | W1 | 29 |
| 5/15/2021 | | @ | Mia | W | Baez, J | 2 | 0 | 19 | 11 | .633 | 9-1 | W2 | 30 |
| 5/17/2021 | | @ | Phi | L | | 4 | 5 | 19 | 12 | .613 | 8-2 | L1 | 31 |
| 5/17/2021 | | | ChC | W | Baez, J | 3 | 1 | 20 | 12 | .625 | 8-2 | W1 | 32 |
| 5/18/2021 | | @ | Phi | L | | 5 | 10 | 20 | 13 | .606 | 7-3 | L1 | 33 |
| 5/18/2021 | | | ChC | L | | 2 | 7 | 20 | 14 | .588 | 6-4 | L2 | 34 |
| 5/19/2021 | | @ | Phi | W | Evans, P | 4 | 2 | 21 | 14 | .600 | 6-4 | W1 | 35 |
| 5/19/2021 | | | ChC | W | Dickerson, A | 20 | 7 | 22 | 14 | .611 | 6-4 | W2 | 36 |
| 5/21/2021 | | @ | Atl | W | d'Arnaud, T | 3 | 2 | 23 | 14 | .622 | 6-4 | W3 | 37 |
| 5/21/2021 | | | Cin | L | | 2 | 15 | 23 | 15 | .605 | 6-4 | L1 | 38 |
| 5/22/2021 | | @ | Atl | L | | 7 | 8 | 23 | 16 | .590 | 5-5 | L2 | 39 |
| 5/22/2021 | | | Cin | L | | 2 | 5 | 23 | 17 | .575 | 4-6 | L3 | 40 |
| 5/23/2021 | | @ | Atl | W | Dickerson, A | 8 | 5 | 24 | 17 | .585 | 5-5 | W1 | 41 |
| 5/23/2021 | | | Cin | W | Happ, I | 4 | 3 | 25 | 17 | .595 | 5-5 | W2 | 42 |
| 5/24/2021 | | @ | NYM | W | Evans, P | 3 | 2 | 26 | 17 | .605 | 6-4 | W3 | 43 |
| 5/24/2021 | | | Mil | L | | 3 | 4 | 26 | 18 | .591 | 6-4 | L1 | 44 |
| 5/25/2021 | | @ | NYM | W | Dickerson, A | 7 | 0 | 27 | 18 | .600 | 6-4 | W1 | 45 |
| 5/25/2021 | | | Mil | L | | 0 | 6 | 27 | 19 | .587 | 5-5 | L1 | 46 |
| 5/26/2021 | | @ | NYM | W | Arroyo, C | 8 | 3 | 28 | 19 | .596 | 5-5 | W1 | 47 |
| 5/26/2021 | | | Mil | L | | 2 | 3 | 28 | 20 | .583 | 5-5 | L1 | 48 |
| 5/28/2021 | | @ | Was | W | Dickerson, A | 4 | 2 | 29 | 20 | .592 | 6-4 | W1 | 49 |
| 5/28/2021 | | | StL | W | Happ, I | 5 | 2 | 30 | 20 | .600 | 7-3 | W2 | 50 |
| 5/29/2021 | | @ | Was | L | | 3 | 11 | 30 | 21 | .588 | 6-4 | L1 | 51 |
| 5/29/2021 | | | StL | L | | 6 | 9 | 30 | 22 | .577 | 5-5 | L2 | 52 |
| 5/30/2021 | | @ | Was | L | | 6 | 9 | 30 | 23 | .566 | 4-6 | L3 | 53 |
| 5/30/2021 | | | StL | L | | 5 | 8 | 30 | 24 | .556 | 4-6 | L4 | 54 |
| 6/14/2021 | | @ | KC | W | Happ, I | 6 | 2 | 31 | 24 | .564 | 4-6 | W1 | 55 |
| 6/14/2021 | | | Bos | L | | 0 | 7 | 31 | 25 | .554 | 4-6 | L1 | 56 |
| 6/15/2021 | | @ | KC | L | | 6 | 8 | 31 | 26 | .544 | 3-7 | L2 | 57 |
| 6/15/2021 | | | Bos | L | | 0 | 6 | 31 | 27 | .534 | 3-7 | L3 | 58 |
| 6/16/2021 | | @ | KC | W | d'Arnaud, T | 3 | 2 | 32 | 27 | .542 | 3-7 | W1 | 59 |
| 6/16/2021 | | | Bos | W | Cabrera, M | 1 | 0 | 33 | 27 | .550 | 3-7 | W2 | 60 |
| 6/17/2021 | | @ | ChW | L | | 4 | 8 | 33 | 28 | .541 | 3-7 | L1 | 61 |
| 6/17/2021 | | | NYY | L | | 0 | 10 | 33 | 29 | .532 | 3-7 | L2 | 62 |
| 6/18/2021 | | @ | ChW | L | | 2 | 3 | 33 | 30 | .524 | 3-7 | L3 | 63 |
| 6/18/2021 | | | NYY | W | LeMahieu, D | 3 | 1 | 34 | 30 | .531 | 4-6 | W1 | 64 |
| 6/19/2021 | | @ | ChW | W | d'Arnaud, T | 11 | 7 | 35 | 30 | .538 | 4-6 | W2 | 65 |
| 6/19/2021 | | | NYY | L | | 1 | 6 | 35 | 31 | .530 | 4-6 | L1 | 66 |
| 6/21/2021 | | @ | Min | W | Evans, P | 12 | 3 | 36 | 31 | .537 | 5-5 | W1 | 67 |
| 6/21/2021 | | | TB | W | Merrifield, W | 11 | 6 | 37 | 31 | .544 | 6-4 | W2 | 68 |
| 6/22/2021 | | @ | Min | L | | 5 | 6 | 37 | 32 | .536 | 5-5 | L1 | 69 |
| 6/22/2021 | | | TB | W | Happ, I | 7 | 4 | 38 | 32 | .543 | 5-5 | W1 | 70 |
| 6/23/2021 | | @ | Min | W | Baez, J | 5 | 2 | 39 | 32 | .549 | 6-4 | W2 | 71 |
| 6/23/2021 | | | TB | W | d'Arnaud, T | 15 | 4 | 40 | 32 | .556 | 7-3 | W3 | 72 |
| 6/24/2021 | | @ | Cle | W | Happ, I | 6 | 4 | 41 | 32 | .562 | 8-2 | W4 | 73 |
| 6/24/2021 | | | Tor | W | Engel, A | 9 | 4 | 42 | 32 | .568 | 8-2 | W5 | 74 |
| 6/25/2021 | | @ | Cle | W | Cabrera, M | 3 | 2 | 43 | 32 | .573 | 8-2 | W6 | 75 |
| 6/25/2021 | | | Tor | W | Happ, I | 6 | 2 | 44 | 32 | .579 | 9-1 | W7 | 76 |
| 6/26/2021 | | @ | Cle | W | Evans, P | 2 | 0 | 45 | 32 | .584 | 9-1 | W8 | 77 |
| 6/26/2021 | | | Tor | W | Cabrera, M | 6 | 2 | 46 | 32 | .590 | 9-1 | W9 | 78 |
| 6/28/2021 | | @ | Det | W | Happ, I | 8 | 7 | 47 | 32 | .595 | 10-0 | W10 | 79 |
| 6/28/2021 | | | Bal | L | | 5 | 10 | 47 | 33 | .587 | 9-1 | L1 | 80 |
| 6/29/2021 | | @ | Det | W | Alonso, P | 8 | 4 | 48 | 33 | .593 | 9-1 | W1 | 81 |
| 6/29/2021 | | | Bal | W | Dickerson, A | 4 | 3 | 49 | 33 | .598 | 9-1 | W2 | 82 |
| 6/30/2021 | | @ | Det | L | | 4 | 7 | 49 | 34 | .590 | 8-2 | L1 | 83 |
| 6/30/2021 | | | Bal | L | | 2 | 8 | 49 | 35 | .583 | 7-3 | L2 | 84 |
| 7/15/2021 | | @ | Oak | L | | 1 | 6 | 49 | 36 | .576 | 6-4 | L3 | 85 |
| 7/15/2021 | | | LAA | W | Baez, J | 5 | 3 | 50 | 36 | .581 | 6-4 | W1 | 86 |
| 7/16/2021 | | @ | Oak | L | | 0 | 5 | 50 | 37 | .575 | 5-5 | L1 | 87 |
| 7/16/2021 | | | LAA | W | Dickerson, A | 14 | 4 | 51 | 37 | .580 | 5-5 | W1 | 88 |
| 7/17/2021 | | @ | Oak | W | Merrifield, W | 9 | 0 | 52 | 37 | .584 | 5-5 | W2 | 89 |
| 7/17/2021 | | | LAA | L | | 2 | 6 | 52 | 38 | .578 | 5-5 | L1 | 90 |
| 7/19/2021 | | | Hou | W | d'Arnaud, T | 11 | 0 | 53 | 38 | .582 | 5-5 | W1 | 91 |
| 7/19/2021 | | @ | Tex | W | Merrifield, W | 6 | 3 | 54 | 38 | .587 | 5-5 | W2 | 92 |
| 7/20/2021 | | | Hou | W | La Stella, T | 7 | 2 | 55 | 38 | .591 | 6-4 | W3 | 93 |
| 7/20/2021 | | @ | Tex | W | | 6 | 1 | 56 | 38 | .596 | 7-3 | W4 | 94 |
| 7/21/2021 | | | Hou | W | Merrifield, W | 5 | 1 | 57 | 38 | .600 | 8-2 | W5 | 95 |
| 7/21/2021 | | @ | Tex | L | | 3 | 4 | 57 | 39 | .594 | 7-3 | L1 | 96 |
| 7/22/2021 | | @ | Hou | W | | 14 | 2 | 58 | 39 | .598 | 8-2 | W1 | 97 |
| 7/22/2021 | | | Tex | W | Merrifield, W | 11 | 3 | 59 | 39 | .602 | 8-2 | W2 | 98 |
| 7/23/2021 | | @ | Hou | W | Engel, A | 6 | 0 | 60 | 39 | .606 | 8-2 | W3 | 99 |
| 7/23/2021 | | | Tex | W | LeMahieu, D | 9 | 8 | 61 | 39 | .610 | 9-1 | W4 | 100 |
| 7/24/2021 | | @ | Hou | L | | 2 | 3 | 61 | 40 | .604 | 8-2 | L1 | 101 |
| 7/24/2021 | | | Tex | W | Alonso, P | 4 | 0 | 62 | 40 | .608 | 8-2 | W1 | 102 |
| 7/26/2021 | | | Oak | W | LeMahieu, D | 4 | 2 | 63 | 40 | .612 | 8-2 | W2 | 103 |
| 7/26/2021 | | @ | LAA | W | Merrifield, W | 5 | 3 | 64 | 40 | .615 | 8-2 | W3 | 104 |
| 7/27/2021 | | | Oak | W | d'Arnaud, T | 5 | 2 | 65 | 40 | .619 | 8-2 | W4 | 105 |
| 7/27/2021 | | @ | LAA | L | | 6 | 10 | 65 | 41 | .613 | 8-2 | L1 | 106 |
| 7/28/2021 | | | Oak | W | Happ, I | 3 | 1 | 66 | 41 | .617 | 8-2 | W1 | 107 |
| 7/28/2021 | | @ | LAA | W | LeMahieu, D | 4 | 1 | 67 | 41 | .620 | 8-2 | W2 | 108 |
| 8/13/2021 | | @ | Bal | L | | 2 | 3 | 67 | 42 | .615 | 7-3 | L1 | 109 |
| 8/13/2021 | | | KC | W | Happ, I | 1 | 0 | 68 | 42 | .618 | 7-3 | W1 | 110 |
| 8/14/2021 | | @ | Bal | W | Merrifield, W | 7 | 4 | 69 | 42 | .622 | 8-2 | W2 | 111 |
| 8/14/2021 | | | KC | W | Engel, A | 11 | 4 | 70 | 42 | .625 | 8-2 | W3 | 112 |
| 8/15/2021 | | @ | Bal | L | | 0 | 3 | 70 | 43 | .619 | 7-3 | L1 | 113 |
| 8/15/2021 | | | KC | L | | 4 | 6 | 70 | 44 | .614 | 6-4 | L2 | 114 |
| 8/16/2021 | | | Min | W | d'Arnaud, T | 7 | 1 | 71 | 44 | .617 | 6-4 | W1 | 115 |
| 8/16/2021 | | @ | TB | W | Dickerson, A | 12 | 7 | 72 | 44 | .621 | 7-3 | W2 | 116 |
| 8/17/2021 | | | Min | W | Engel, A | 3 | 2 | 73 | 44 | .624 | 7-3 | W3 | 117 |
| 8/17/2021 | | @ | TB | W | LeMahieu, D | 6 | 3 | 74 | 44 | .627 | 7-3 | W4 | 118 |
| 8/18/2021 | | | Min | W | Baez, J | 5 | 1 | 75 | 44 | .630 | 8-2 | W5 | 119 |
| 8/18/2021 | | @ | TB | W | Alonso, P | 7 | 0 | 76 | 44 | .633 | 8-2 | W6 | 120 |
| 8/20/2021 | | | ChW | L | | 3 | 7 | 76 | 45 | .628 | 7-3 | L1 | 121 |
| 8/20/2021 | | @ | Tor | W | d'Arnaud, T | 21 | 3 | 77 | 45 | .631 | 7-3 | W1 | 122 |
| 8/21/2021 | | | ChW | L | | 3 | 5 | 77 | 46 | .626 | 7-3 | L1 | 123 |
| 8/21/2021 | | @ | Tor | W | LeMahieu, D | 8 | 4 | 78 | 46 | .629 | 8-2 | W1 | 124 |
| 8/22/2021 | | | ChW | L | | 2 | 3 | 78 | 47 | .624 | 7-3 | L1 | 125 |
| 8/22/2021 | | @ | Tor | L | | 3 | 4 | 78 | 48 | .619 | 6-4 | L2 | 126 |
| 8/23/2021 | | @ | Bos | W | Cabrera, M | 6 | 2 | 79 | 48 | .622 | 6-4 | W1 | 127 |
| 8/23/2021 | | | Det | L | | 3 | 4 | 79 | 49 | .617 | 5-5 | L1 | 128 |
| 8/24/2021 | | @ | Bos | W | Farmer, K | 5 | 3 | 80 | 49 | .620 | 5-5 | W1 | 129 |
| 8/24/2021 | | | Det | L | | 5 | 6 | 80 | 50 | .615 | 4-6 | L1 | 130 |
| 8/25/2021 | | @ | Bos | W | d'Arnaud, T | 7 | 1 | 81 | 50 | .618 | 5-5 | W1 | 131 |
| 8/25/2021 | | | Det | L | | 3 | 4 | 81 | 51 | .614 | 4-6 | L1 | 132 |
| 8/27/2021 | | @ | NYY | W | LeMahieu, D | 11 | 1 | 82 | 51 | .617 | 5-5 | W1 | 133 |
| 8/27/2021 | | | Cle | W | Cabrera, M | 9 | 4 | 83 | 51 | .619 | 5-5 | W2 | 134 |
| 8/28/2021 | | @ | NYY | W | d'Arnaud, T | 2 | 0 | 84 | 51 | .622 | 6-4 | W3 | 135 |
| 8/28/2021 | | | Cle | W | d'Arnaud, T | 4 | 1 | 85 | 51 | .625 | 7-3 | W4 | 136 |
| 8/29/2021 | | @ | NYY | W | Baez, J | 8 | 2 | 86 | 51 | .628 | 7-3 | W5 | 137 |
| 8/29/2021 | | | Cle | W | Dickerson, A | 6 | 1 | 87 | 51 | .630 | 8-2 | W6 | 138 |
| 9/13/2021 | | | Hou | W | Alonso, P | 5 | 2 | 88 | 51 | .633 | 8-2 | W7 | 139 |
| 9/13/2021 | | @ | Tex | W | Contreras, W | 6 | 1 | 89 | 51 | .636 | 9-1 | W8 | 140 |
| 9/14/2021 | | | Hou | W | Dickerson, A | 3 | 0 | 90 | 51 | .638 | 9-1 | W9 | 141 |
| 9/14/2021 | | @ | Tex | L | | 0 | 3 | 90 | 52 | .634 | 9-1 | L1 | 142 |
| 9/15/2021 | | | Hou | W | LeMahieu, D | 5 | 2 | 91 | 52 | .636 | 9-1 | W1 | 143 |
| 9/15/2021 | | @ | Tex | W | La Stella, T | 3 | 2 | 92 | 52 | .639 | 9-1 | W2 | 144 |
| 9/17/2021 | | | Oak | W | La Stella, T | 7 | 2 | 93 | 52 | .641 | 9-1 | W3 | 145 |
| 9/17/2021 | | @ | LAA | W | | 10 | 1 | 94 | 52 | .644 | 9-1 | W4 | 146 |
| 9/18/2021 | | | Oak | W | LeMahieu, D | 5 | 3 | 95 | 52 | .646 | 9-1 | W5 | 147 |
| 9/18/2021 | | @ | LAA | L | | 3 | 7 | 95 | 53 | .642 | 8-2 | L1 | 148 |
| 9/19/2021 | | | Oak | W | LeMahieu, D | 4 | 1 | 96 | 53 | .644 | 8-2 | W1 | 149 |
| 9/19/2021 | | @ | LAA | L | | 1 | 2 | 96 | 54 | .640 | 7-3 | L1 | 150 |
| 9/20/2021 | | @ | Oak | W | Dickerson, A | 7 | 1 | 97 | 54 | .642 | 7-3 | W1 | 151 |
| 9/20/2021 | | | LAA | L | | 4 | 5 | 97 | 55 | .638 | 7-3 | L1 | 152 |
| 9/21/2021 | | @ | Oak | L | | 3 | 8 | 97 | 56 | .634 | 6-4 | L2 | 153 |
| 9/21/2021 | | | LAA | W | Engel, A | 4 | 3 | 98 | 56 | .636 | 6-4 | W1 | 154 |
| 9/22/2021 | | @ | Oak | L | | 5 | 6 | 98 | 57 | .632 | 5-5 | L1 | 155 |
| 9/22/2021 | | | LAA | L | | 4 | 6 | 98 | 58 | .628 | 4-6 | L2 | 156 |
| 9/24/2021 | | @ | Hou | W | LeMahieu, D | 4 | 3 | 99 | 58 | .631 | 4-6 | W1 | 157 |
| 9/24/2021 | | | Tex | W | La Stella, T | 6 | 2 | 100 | 58 | .633 | 5-5 | W2 | 158 |
| 9/25/2021 | | @ | Hou | W | Happ, I | 17 | 6 | 101 | 58 | .635 | 5-5 | W3 | 159 |
| 9/25/2021 | | | Tex | W | Alonso, P | 4 | 1 | 102 | 58 | .637 | 6-4 | W4 | 160 |
| 9/26/2021 | | @ | Hou | L | | 4 | 5 | 102 | 59 | .634 | 5-5 | L1 | 161 |
| 9/26/2021 | | | Tex | W | La Stella, T | 4 | 3 | 103 | 59 | .636 | 6-4 | W1 | 162 |