Team game results - 2021 Chicago White Sox
Regular season
| Primary |
| Date | # | | Opp | | Score | Inn | Starter | T | W/L | Save | Versus | T |
| 4/15/2021 | | | KC | W | 3-0 | | Tanaka, M | R | Tanaka, M | Zimmer, K | Lamet, D | R |
| 4/15/2021 | | @ | Min | L | 5-11 | | Freeland, K | L | Quantrill, C | | Nola, A | R |
| 4/16/2021 | | | KC | W | 9-4 | | Freeland, K | L | Freeland, K | Hoyt, J | Rogers, T | L |
| 4/16/2021 | | @ | Min | W | 7-4 | | Tanaka, M | R | Tanaka, M | Zimmer, K | Allard, K | L |
| 4/17/2021 | | | KC | L | 0-5 | | Keller, M | R | Keller, M | | Singer, B | R |
| 4/17/2021 | | @ | Min | L | 3-6 | | Odorizzi, J | R | Odorizzi, J | | Musgrove, J | R |
| 4/19/2021 | | | Det | W | 3-0 | | Antone, T | R | Zimmer, K | Reyes, A | Lester, J | L |
| 4/19/2021 | | @ | Cle | L | 3-6 | | Eovaldi, N | R | Eovaldi, N | | Weber, R | R |
| 4/20/2021 | | | Det | L | 0-3 | | Tanaka, M | R | Tanaka, M | | Bauer, T | R |
| 4/20/2021 | | @ | Cle | L | 5-6 | 13 | Weaver, L | R | Peralta, F | | Civale, A | R |
| 4/21/2021 | | | Det | W | 2-1 | | Freeland, K | L | Zimmer, K | | Marquez, G | R |
| 4/21/2021 | | @ | Cle | W | 8-6 | 10 | Freeland, K | L | Misiewicz, A | Quantrill, C | Keller, B | R |
| 4/22/2021 | | | Cle | W | 4-1 | | Keller, M | R | Keller, M | | Sanchez, S | R |
| 4/22/2021 | | @ | Det | L | 1-2 | | Tanaka, M | R | Tanaka, M | | Cody, K | R |
| 4/23/2021 | | | Cle | W | 7-6 | | Eovaldi, N | R | Antone, T | Zimmer, K | Castano, D | L |
| 4/23/2021 | | @ | Det | L | 1-6 | | Odorizzi, J | R | Odorizzi, J | | Bauer, T | R |
| 4/24/2021 | | | Cle | W | 4-2 | | Tanaka, M | R | Antone, T | Zimmer, K | Civale, A | R |
| 4/24/2021 | | @ | Det | W | 4-3 | | Eovaldi, N | R | Zimmer, K | Quantrill, C | Lester, J | L |
| 4/26/2021 | | | Min | L | 0-1 | | Antone, T | R | Antone, T | | Kremer, D | R |
| 4/26/2021 | | @ | KC | W | 9-7 | 19 | Weaver, L | R | Zimmer, K | Quantrill, C | Arrieta, J | R |
| 4/27/2021 | | | Min | W | 7-2 | | Freeland, K | L | Freeland, K | | Urena, J | R |
| 4/27/2021 | | @ | KC | W | 10-2 | | Freeland, K | L | Freeland, K | Peralta, F | Rogers, T | L |
| 4/28/2021 | | | Min | W | 4-0 | | Eovaldi, N | R | Eovaldi, N | Taylor, B | Nola, A | R |
| 4/28/2021 | | @ | KC | W | 7-3 | | Tanaka, M | R | Tanaka, M | | Lindblom, J | R |
| 5/13/2021 | | @ | SF | W | 4-0 | | Eovaldi, N | R | Eovaldi, N | | Anderson, I | R |
| 5/13/2021 | | | NYM | W | 4-3 | | Keller, M | R | Keller, M | Zimmer, K | Gonzalez, G | L |
| 5/14/2021 | | @ | SF | L | 1-2 | | Freeland, K | L | Freeland, K | | Wheeler, Z | R |
| 5/14/2021 | | | NYM | W | 5-1 | | Eovaldi, N | R | Eovaldi, N | Taylor, B | Mengden, D | R |
| 5/15/2021 | | @ | SF | L | 1-6 | | Braymer, B | L | Braymer, B | | Peterson, D | L |
| 5/15/2021 | | | NYM | L | 0-5 | | Freeland, K | L | Freeland, K | | Luzardo, J | L |
| 5/17/2021 | | @ | SD | W | 6-4 | | Weaver, L | R | Peralta, F | Quantrill, C | Gausman, K | R |
| 5/17/2021 | | | Mia | W | 3-2 | | Antone, T | R | Antone, T | Zimmer, K | Tomlin, J | R |
| 5/18/2021 | | @ | SD | L | 8-10 | | Odorizzi, J | R | Odorizzi, J | | Perez, M | L |
| 5/18/2021 | | | Mia | W | 4-1 | | Keller, M | R | Hoyt, J | Zimmer, K | Benjamin, W | L |
| 5/19/2021 | | @ | SD | W | 5-4 | | Eovaldi, N | R | Hoyt, J | Quantrill, C | Cease, D | R |
| 5/19/2021 | | | Mia | L | 4-7 | | Tanaka, M | R | Tanaka, M | | Fleming, J | L |
| 5/21/2021 | | | Was | L | 0-8 | | Eovaldi, N | R | Eovaldi, N | | Gonzales, M | L |
| 5/21/2021 | | @ | Ari | W | 3-2 | 11 | Freeland, K | L | Misiewicz, A | Hoyt, J | Maeda, K | R |
| 5/22/2021 | | | Was | L | 3-5 | | Freeland, K | L | Freeland, K | | Bassitt, C | R |
| 5/22/2021 | | @ | Ari | W | 7-0 | | Braymer, B | L | Braymer, B | Peralta, F | Gray, S | R |
| 5/23/2021 | | | Was | L | 4-7 | | Keller, M | R | Keller, M | | Kelly, M | R |
| 5/23/2021 | | @ | Ari | L | 2-14 | | Weaver, L | R | Weaver, L | | Ryu, H | L |
| 5/24/2021 | | | Atl | W | 7-2 | | Antone, T | R | Antone, T | | Castellani, R | R |
| 5/24/2021 | | @ | Col | W | 8-6 | | Odorizzi, J | R | Odorizzi, J | Taylor, B | Godley, Z | R |
| 5/25/2021 | | | Atl | L | 1-5 | | Tanaka, M | R | Tanaka, M | | Corbin, P | L |
| 5/25/2021 | | @ | Col | W | 8-7 | | Eovaldi, N | R | Taylor, B | Misiewicz, A | Means, J | L |
| 5/26/2021 | | | Atl | W | 9-8 | 10 | Eovaldi, N | R | Turley, N | | Milone, T | L |
| 5/26/2021 | | @ | Col | L | 2-4 | | Freeland, K | L | Freeland, K | | Bieber, S | R |
| 5/28/2021 | | @ | LAD | L | 0-1 | | Braymer, B | L | Braymer, B | | deGrom, J | R |
| 5/28/2021 | | | Phi | L | 0-2 | | Freeland, K | L | Freeland, K | | Sheffield, J | L |
| 5/29/2021 | | @ | LAD | L | 3-5 | | Weaver, L | R | Reyes, A | | Porcello, R | R |
| 5/29/2021 | | | Phi | L | 2-5 | | Keller, M | R | Keller, M | | Manaea, S | L |
| 5/30/2021 | | @ | LAD | L | 1-6 | | Odorizzi, J | R | Odorizzi, J | | Lopez, P | R |
| 5/30/2021 | | | Phi | L | 5-7 | | Tanaka, M | R | Reyes, A | | Hernandez, E | R |
| 6/14/2021 | | | Hou | W | 5-4 | | Eovaldi, N | R | Hoyt, J | Quantrill, C | Walker, T | R |
| 6/14/2021 | | @ | NYY | W | 4-1 | | Freeland, K | L | Freeland, K | Quantrill, C | Lynn, L | R |
| 6/15/2021 | | | Hou | L | 3-4 | | Tanaka, M | R | Tanaka, M | | Dunn, J | R |
| 6/15/2021 | | @ | NYY | L | 1-2 | | Weaver, L | R | Weaver, L | | Bundy, D | R |
| 6/16/2021 | | | Hou | W | 8-5 | | Keller, M | R | Reyes, A | Taylor, B | Gray, J | R |
| 6/16/2021 | | @ | NYY | L | 3-14 | | Odorizzi, J | R | Odorizzi, J | | May, D | R |
| 6/17/2021 | | @ | Bal | W | 5-1 | | Tanaka, M | R | Tanaka, M | | Cahill, T | R |
| 6/17/2021 | | | Sea | W | 8-4 | | Antone, T | R | Sherriff, R | | Shoemaker, M | R |
| 6/18/2021 | | @ | Bal | L | 1-2 | | Eovaldi, N | R | Eovaldi, N | | Urias, J | L |
| 6/18/2021 | | | Sea | W | 3-2 | | Freeland, K | L | Freeland, K | Taylor, B | Urquidy, J | R |
| 6/19/2021 | | @ | Bal | L | 0-13 | | Freeland, K | L | Freeland, K | | Turnbull, S | R |
| 6/19/2021 | | | Sea | L | 7-11 | | Eovaldi, N | R | Eovaldi, N | | Minor, M | L |
| 6/21/2021 | | | Oak | W | 1-0 | | Tanaka, M | R | Taylor, B | Antone, T | Fried, M | L |
| 6/21/2021 | | @ | TB | W | 6-0 | | Weaver, L | R | Weaver, L | | Smeltzer, D | L |
| 6/22/2021 | | | Oak | W | 6-3 | 10 | Keller, M | R | Taylor, B | | Scherzer, M | R |
| 6/22/2021 | | @ | TB | W | 5-3 | | Odorizzi, J | R | Reyes, A | Taylor, B | Anderson, B | L |
| 6/23/2021 | | | Oak | W | 1-0 | | Freeland, K | L | Sherriff, R | | Cueto, J | R |
| 6/23/2021 | | @ | TB | W | 7-1 | | Tanaka, M | R | Tanaka, M | | Wright, K | R |
| 6/24/2021 | | | LAA | W | 3-0 | | Antone, T | R | Antone, T | Reyes, A | Darvish, Y | R |
| 6/24/2021 | | @ | Tor | W | 8-5 | | Eovaldi, N | R | Reyes, A | Quantrill, C | Velasquez, V | R |
| 6/25/2021 | | | LAA | W | 6-5 | 10 | Eovaldi, N | R | Quantrill, C | | Boyd, M | L |
| 6/25/2021 | | @ | Tor | W | 3-2 | | Freeland, K | L | Taylor, B | Turley, N | Roark, T | R |
| 6/26/2021 | | | LAA | W | 4-2 | | Tanaka, M | R | Tanaka, M | Reyes, A | Bumgarner, M | L |
| 6/26/2021 | | @ | Tor | W | 7-3 | | Weaver, L | R | Peralta, F | | Brewer, C | R |
| 6/28/2021 | | @ | Bos | L | 0-1 | | Tanaka, M | R | Tanaka, M | | Javier, C | R |
| 6/28/2021 | | | Tex | W | 6-4 | | Keller, M | R | Turley, N | Taylor, B | Stripling, R | R |
| 6/29/2021 | | @ | Bos | W | 11-8 | | Reyes, A | R | Turley, N | | Webb, L | R |
| 6/29/2021 | | | Tex | W | 13-10 | | Freeland, K | L | Freeland, K | | Fulmer, M | R |
| 6/30/2021 | | @ | Bos | L | 3-8 | | Eovaldi, N | R | Eovaldi, N | | Kim, K | L |
| 6/30/2021 | | | Tex | W | 16-5 | | Eovaldi, N | R | Eovaldi, N | Quantrill, C | Crowe, W | R |
| 7/15/2021 | | | Det | L | 6-17 | | Freeland, K | L | Freeland, K | | Bauer, T | R |
| 7/15/2021 | | @ | Cle | W | 13-2 | | Weaver, L | R | Weaver, L | Taylor, B | Civale, A | R |
| 7/16/2021 | | | Det | W | 7-6 | | Tanaka, M | R | Tanaka, M | Antone, T | Marquez, G | R |
| 7/16/2021 | | @ | Cle | W | 5-3 | | Freeland, K | L | Freeland, K | Taylor, B | Bielak, B | R |
| 7/17/2021 | | | Det | W | 3-1 | | Keller, M | R | Keller, M | Antone, T | Flaherty, J | R |
| 7/17/2021 | | @ | Cle | W | 9-7 | | Odorizzi, J | R | Quantrill, C | Zimmer, K | Sanchez, S | R |
| 7/19/2021 | | | Min | W | 3-1 | | Antone, T | R | Antone, T | Sherriff, R | Nola, A | R |
| 7/19/2021 | | @ | KC | W | 6-1 | | Peralta, F | R | Peralta, F | | Arrieta, J | R |
| 7/20/2021 | | | Min | L | 3-4 | | Freeland, K | L | Freeland, K | | Akin, K | L |
| 7/20/2021 | | @ | KC | W | 4-0 | | Antone, T | R | Antone, T | | Lamet, D | R |
| 7/21/2021 | | | Min | W | 12-11 | | Tanaka, M | R | Misiewicz, A | Zimmer, K | Mahle, T | R |
| 7/21/2021 | | @ | KC | W | 6-5 | | Weaver, L | R | Zimmer, K | Hoyt, J | Voth, A | R |
| 7/22/2021 | | | KC | W | 5-1 | | Keller, M | R | Antone, T | Zimmer, K | Singer, B | R |
| 7/22/2021 | | @ | Min | W | 7-1 | | Freeland, K | L | Freeland, K | | Musgrove, J | R |
| 7/23/2021 | | | KC | W | 3-1 | | Eovaldi, N | R | Eovaldi, N | Zimmer, K | Lindblom, J | R |
| 7/23/2021 | | @ | Min | W | 8-7 | | Odorizzi, J | R | Quantrill, C | Zimmer, K | Mahle, T | R |
| 7/24/2021 | | | KC | W | 4-3 | | Freeland, K | L | Hoyt, J | Zimmer, K | Lamet, D | R |
| 7/24/2021 | | @ | Min | W | 3-1 | | Peralta, F | R | Misiewicz, A | Zimmer, K | Nola, A | R |
| 7/26/2021 | | | Cle | W | 7-3 | | Antone, T | R | Antone, T | | Houck, T | R |
| 7/26/2021 | | @ | Det | W | 6-2 | | Antone, T | R | Quantrill, C | | Flaherty, J | R |
| 7/27/2021 | | | Cle | W | 7-6 | | Tanaka, M | R | Zimmer, K | | Bielak, B | R |
| 7/27/2021 | | @ | Det | L | 3-5 | | Weaver, L | R | Hoyt, J | | Bauer, T | R |
| 7/28/2021 | | | Cle | W | 9-7 | | Eovaldi, N | R | Sherriff, R | Zimmer, K | Shoemaker, M | R |
| 7/28/2021 | | @ | Det | L | 0-2 | | Freeland, K | L | Freeland, K | | Cody, K | R |
| 8/13/2021 | | | Bos | L | 0-3 | | Keller, M | R | Keller, M | | Kim, K | L |
| 8/13/2021 | | @ | LAA | W | 5-4 | | Weaver, L | R | Weaver, L | Zimmer, K | Boyd, M | L |
| 8/14/2021 | | | Bos | L | 0-5 | | Tanaka, M | R | Tanaka, M | | Hudson, D | R |
| 8/14/2021 | | @ | LAA | L | 5-7 | | Tanaka, M | R | Turley, N | | Pineda, M | R |
| 8/15/2021 | | | Bos | L | 1-6 | | Freeland, K | L | Zimmer, K | | Javier, C | R |
| 8/15/2021 | | @ | LAA | L | 0-2 | | Freeland, K | L | Freeland, K | | Gomber, A | L |
| 8/16/2021 | | | NYY | L | 0-2 | | Antone, T | R | Antone, T | | Bundy, D | R |
| 8/16/2021 | | @ | Tex | W | 7-1 | | Montgomery, M | L | Hoyt, J | | Thorpe, L | L |
| 8/17/2021 | | | NYY | L | 4-7 | | Eovaldi, N | R | Eovaldi, N | | Lynn, L | R |
| 8/17/2021 | | @ | Tex | L | 3-4 | | Eovaldi, N | R | Eovaldi, N | | Stripling, R | R |
| 8/18/2021 | | | NYY | L | 2-4 | | Keller, M | R | Keller, M | | Burnes, C | R |
| 8/18/2021 | | @ | Tex | W | 5-2 | | Weaver, L | R | Misiewicz, A | Hoyt, J | Sanchez, A | R |
| 8/20/2021 | | | TB | W | 7-1 | | Tanaka, M | R | Tanaka, M | Zimmer, K | Soroka, M | R |
| 8/20/2021 | | @ | Sea | W | 7-3 | | Tanaka, M | R | Turley, N | Zimmer, K | Glasnow, T | R |
| 8/21/2021 | | | TB | W | 9-5 | | Freeland, K | L | Freeland, K | | Garrett, B | L |
| 8/21/2021 | | @ | Sea | W | 5-3 | | Freeland, K | L | Freeland, K | Zimmer, K | Skubal, T | L |
| 8/22/2021 | | | TB | W | 7-3 | | Eovaldi, N | R | Eovaldi, N | Antone, T | Anderson, B | L |
| 8/22/2021 | | @ | Sea | W | 3-2 | | Montgomery, M | L | Montgomery, M | Taylor, B | Fedde, E | R |
| 8/23/2021 | | @ | Hou | W | 10-4 | | Eovaldi, N | R | Eovaldi, N | | Gray, J | R |
| 8/23/2021 | | | Tor | W | 5-1 | | Antone, T | R | Antone, T | | Velasquez, V | R |
| 8/24/2021 | | @ | Hou | L | 0-4 | | Weaver, L | R | Weaver, L | | Walker, T | R |
| 8/24/2021 | | | Tor | W | 9-1 | | Keller, M | R | Keller, M | | Lorenzen, M | R |
| 8/25/2021 | | @ | Hou | W | 5-1 | | Tanaka, M | R | Peralta, F | | Ponce de Leon, D | R |
| 8/25/2021 | | | Tor | L | 8-13 | | Tanaka, M | R | Tanaka, M | | Newcomb, S | L |
| 8/27/2021 | | | Bal | L | 5-7 | | Freeland, K | L | Zimmer, K | | Cobb, A | R |
| 8/27/2021 | | @ | Oak | L | 3-8 | | Freeland, K | L | Freeland, K | | Scherzer, M | R |
| 8/28/2021 | | | Bal | W | 4-3 | | Eovaldi, N | R | Hoyt, J | Zimmer, K | Mills, A | R |
| 8/28/2021 | | @ | Oak | L | 2-6 | | Montgomery, M | L | Griffin, F | | Dobnak, R | R |
| 8/29/2021 | | | Bal | W | 7-1 | | Keller, M | R | Antone, T | | Lopez, J | R |
| 8/29/2021 | | @ | Oak | W | 2-1 | | Eovaldi, N | R | Eovaldi, N | Zimmer, K | Fried, M | L |
| 9/13/2021 | | | Min | W | 12-1 | | Freeland, K | L | Freeland, K | | Musgrove, J | R |
| 9/13/2021 | | @ | KC | L | 4-8 | | Tanaka, M | R | Tanaka, M | | Lamet, D | R |
| 9/14/2021 | | | Min | W | 5-4 | | Tanaka, M | R | Sherriff, R | | Kremer, D | R |
| 9/14/2021 | | @ | KC | W | 6-3 | 15 | Freeland, K | L | Turley, N | Misiewicz, A | Voth, A | R |
| 9/15/2021 | | | Min | L | 4-5 | | Eovaldi, N | R | Taylor, B | | Nola, A | R |
| 9/15/2021 | | @ | KC | W | 8-6 | | Weaver, L | R | Hoyt, J | Taylor, B | Singer, B | R |
| 9/17/2021 | | | Cle | W | 6-3 | | Antone, T | R | Sherriff, R | Zimmer, K | Houck, T | R |
| 9/17/2021 | | @ | Det | W | 5-1 | | Peralta, F | R | Turley, N | | Cody, K | R |
| 9/18/2021 | | | Cle | L | 3-4 | | Freeland, K | L | Freeland, K | | Sanchez, S | R |
| 9/18/2021 | | @ | Det | L | 1-2 | 13 | Quantrill, C | R | Reyes, A | | Bauer, T | R |
| 9/19/2021 | | | Cle | W | 21-10 | | Tanaka, M | R | Tanaka, M | | Suarez, J | L |
| 9/19/2021 | | @ | Det | W | 5-4 | | Tanaka, M | R | Tanaka, M | Quantrill, C | Marquez, G | R |
| 9/20/2021 | | | Det | W | 7-4 | | Eovaldi, N | R | Eovaldi, N | | Lester, J | L |
| 9/20/2021 | | @ | Cle | W | 4-2 | 10 | Freeland, K | L | Taylor, B | | Castano, D | L |
| 9/21/2021 | | | Det | W | 4-2 | | Keller, M | R | Keller, M | Antone, T | Bauer, T | R |
| 9/21/2021 | | @ | Cle | W | 11-4 | | Weaver, L | R | Turley, N | | Weber, R | R |
| 9/22/2021 | | | Det | W | 3-2 | | Freeland, K | L | Freeland, K | Taylor, B | Cody, K | R |
| 9/22/2021 | | @ | Cle | W | 11-2 | | Peralta, F | R | Peralta, F | | Sanchez, S | R |
| 9/24/2021 | | | KC | W | 8-3 | | Antone, T | R | Hoyt, J | | Arrieta, J | R |
| 9/24/2021 | | @ | Min | W | 10-4 | | Braymer, B | L | Quantrill, C | | Akin, K | L |
| 9/25/2021 | | | KC | L | 2-3 | | Tanaka, M | R | Tanaka, M | | Voth, A | R |
| 9/25/2021 | | @ | Min | W | 4-3 | | Tanaka, M | R | Tanaka, M | Zimmer, K | Allard, K | L |
| 9/26/2021 | | | KC | W | 5-2 | | Keller, M | R | Keller, M | Zimmer, K | Lindblom, J | R |
| 9/26/2021 | | @ | Min | W | 7-4 | | Freeland, K | L | Freeland, K | Quantrill, C | Mahle, T | R |
| Other |
| | | | | | | | | Cumulative |
| Date | # | | Opp | | GWRBI | RF | RA | W | L | Pct | Last10 | Strk | Gm# |
| 4/15/2021 | | | KC | W | Anderson, B | 3 | 0 | 1 | 0 | 1.000 | 1-0 | W1 | 1 |
| 4/15/2021 | | @ | Min | L | | 5 | 11 | 1 | 1 | .500 | 1-1 | L1 | 2 |
| 4/16/2021 | | | KC | W | Hicks, A | 9 | 4 | 2 | 1 | .667 | 2-1 | W1 | 3 |
| 4/16/2021 | | @ | Min | W | Davis, K | 7 | 4 | 3 | 1 | .750 | 3-1 | W2 | 4 |
| 4/17/2021 | | | KC | L | | 0 | 5 | 3 | 2 | .600 | 3-2 | L1 | 5 |
| 4/17/2021 | | @ | Min | L | | 3 | 6 | 3 | 3 | .500 | 3-3 | L2 | 6 |
| 4/19/2021 | | | Det | W | | 3 | 0 | 4 | 3 | .571 | 4-3 | W1 | 7 |
| 4/19/2021 | | @ | Cle | L | | 3 | 6 | 4 | 4 | .500 | 4-4 | L1 | 8 |
| 4/20/2021 | | | Det | L | | 0 | 3 | 4 | 5 | .444 | 4-5 | L2 | 9 |
| 4/20/2021 | | @ | Cle | L | | 5 | 6 | 4 | 6 | .400 | 4-6 | L3 | 10 |
| 4/21/2021 | | | Det | W | Diaz, Y | 2 | 1 | 5 | 6 | .455 | 4-6 | W1 | 11 |
| 4/21/2021 | | @ | Cle | W | O'Neill, T | 8 | 6 | 6 | 6 | .500 | 5-5 | W2 | 12 |
| 4/22/2021 | | | Cle | W | Taylor, C | 4 | 1 | 7 | 6 | .538 | 5-5 | W3 | 13 |
| 4/22/2021 | | @ | Det | L | | 1 | 2 | 7 | 7 | .500 | 4-6 | L1 | 14 |
| 4/23/2021 | | | Cle | W | O'Neill, T | 7 | 6 | 8 | 7 | .533 | 5-5 | W1 | 15 |
| 4/23/2021 | | @ | Det | L | | 1 | 6 | 8 | 8 | .500 | 5-5 | L1 | 16 |
| 4/24/2021 | | | Cle | W | Taylor, C | 4 | 2 | 9 | 8 | .529 | 5-5 | W1 | 17 |
| 4/24/2021 | | @ | Det | W | Tucker, C | 4 | 3 | 10 | 8 | .556 | 6-4 | W2 | 18 |
| 4/26/2021 | | | Min | L | | 0 | 1 | 10 | 9 | .526 | 6-4 | L1 | 19 |
| 4/26/2021 | | @ | KC | W | McNeil, J | 9 | 7 | 11 | 9 | .550 | 7-3 | W1 | 20 |
| 4/27/2021 | | | Min | W | McNeil, J | 7 | 2 | 12 | 9 | .571 | 7-3 | W2 | 21 |
| 4/27/2021 | | @ | KC | W | Anderson, B | 10 | 2 | 13 | 9 | .591 | 7-3 | W3 | 22 |
| 4/28/2021 | | | Min | W | Taylor, C | 4 | 0 | 14 | 9 | .609 | 7-3 | W4 | 23 |
| 4/28/2021 | | @ | KC | W | Rizzo, A | 7 | 3 | 15 | 9 | .625 | 8-2 | W5 | 24 |
| 5/13/2021 | | @ | SF | W | Rizzo, A | 4 | 0 | 16 | 9 | .640 | 8-2 | W6 | 25 |
| 5/13/2021 | | | NYM | W | Hicks, A | 4 | 3 | 17 | 9 | .654 | 9-1 | W7 | 26 |
| 5/14/2021 | | @ | SF | L | | 1 | 2 | 17 | 10 | .630 | 8-2 | L1 | 27 |
| 5/14/2021 | | | NYM | W | Taylor, C | 5 | 1 | 18 | 10 | .643 | 8-2 | W1 | 28 |
| 5/15/2021 | | @ | SF | L | | 1 | 6 | 18 | 11 | .621 | 8-2 | L1 | 29 |
| 5/15/2021 | | | NYM | L | | 0 | 5 | 18 | 12 | .600 | 7-3 | L2 | 30 |
| 5/17/2021 | | @ | SD | W | Machin, V | 6 | 4 | 19 | 12 | .613 | 7-3 | W1 | 31 |
| 5/17/2021 | | | Mia | W | Anderson, B | 3 | 2 | 20 | 12 | .625 | 7-3 | W2 | 32 |
| 5/18/2021 | | @ | SD | L | | 8 | 10 | 20 | 13 | .606 | 6-4 | L1 | 33 |
| 5/18/2021 | | | Mia | W | Torres, G | 4 | 1 | 21 | 13 | .618 | 6-4 | W1 | 34 |
| 5/19/2021 | | @ | SD | W | McNeil, J | 5 | 4 | 22 | 13 | .629 | 6-4 | W2 | 35 |
| 5/19/2021 | | | Mia | L | | 4 | 7 | 22 | 14 | .611 | 5-5 | L1 | 36 |
| 5/21/2021 | | | Was | L | | 0 | 8 | 22 | 15 | .595 | 5-5 | L2 | 37 |
| 5/21/2021 | | @ | Ari | W | Taylor, C | 3 | 2 | 23 | 15 | .605 | 5-5 | W1 | 38 |
| 5/22/2021 | | | Was | L | | 3 | 5 | 23 | 16 | .590 | 5-5 | L1 | 39 |
| 5/22/2021 | | @ | Ari | W | Machin, V | 7 | 0 | 24 | 16 | .600 | 6-4 | W1 | 40 |
| 5/23/2021 | | | Was | L | | 4 | 7 | 24 | 17 | .585 | 5-5 | L1 | 41 |
| 5/23/2021 | | @ | Ari | L | | 2 | 14 | 24 | 18 | .571 | 4-6 | L2 | 42 |
| 5/24/2021 | | | Atl | W | Taylor, C | 7 | 2 | 25 | 18 | .581 | 5-5 | W1 | 43 |
| 5/24/2021 | | @ | Col | W | O'Neill, T | 8 | 6 | 26 | 18 | .591 | 5-5 | W2 | 44 |
| 5/25/2021 | | | Atl | L | | 1 | 5 | 26 | 19 | .578 | 4-6 | L1 | 45 |
| 5/25/2021 | | @ | Col | W | Machin, V | 8 | 7 | 27 | 19 | .587 | 5-5 | W1 | 46 |
| 5/26/2021 | | | Atl | W | Castro, J | 9 | 8 | 28 | 19 | .596 | 6-4 | W2 | 47 |
| 5/26/2021 | | @ | Col | L | | 2 | 4 | 28 | 20 | .583 | 5-5 | L1 | 48 |
| 5/28/2021 | | @ | LAD | L | | 0 | 1 | 28 | 21 | .571 | 5-5 | L2 | 49 |
| 5/28/2021 | | | Phi | L | | 0 | 2 | 28 | 22 | .560 | 4-6 | L3 | 50 |
| 5/29/2021 | | @ | LAD | L | | 3 | 5 | 28 | 23 | .549 | 4-6 | L4 | 51 |
| 5/29/2021 | | | Phi | L | | 2 | 5 | 28 | 24 | .538 | 4-6 | L5 | 52 |
| 5/30/2021 | | @ | LAD | L | | 1 | 6 | 28 | 25 | .528 | 3-7 | L6 | 53 |
| 5/30/2021 | | | Phi | L | | 5 | 7 | 28 | 26 | .519 | 2-8 | L7 | 54 |
| 6/14/2021 | | | Hou | W | Torres, G | 5 | 4 | 29 | 26 | .527 | 3-7 | W1 | 55 |
| 6/14/2021 | | @ | NYY | W | Hicks, A | 4 | 1 | 30 | 26 | .536 | 3-7 | W2 | 56 |
| 6/15/2021 | | | Hou | L | | 3 | 4 | 30 | 27 | .526 | 2-8 | L1 | 57 |
| 6/15/2021 | | @ | NYY | L | | 1 | 2 | 30 | 28 | .517 | 2-8 | L2 | 58 |
| 6/16/2021 | | | Hou | W | Anderson, B | 8 | 5 | 31 | 28 | .525 | 3-7 | W1 | 59 |
| 6/16/2021 | | @ | NYY | L | | 3 | 14 | 31 | 29 | .517 | 3-7 | L1 | 60 |
| 6/17/2021 | | @ | Bal | W | Davis, K | 5 | 1 | 32 | 29 | .525 | 4-6 | W1 | 61 |
| 6/17/2021 | | | Sea | W | McNeil, J | 8 | 4 | 33 | 29 | .532 | 5-5 | W2 | 62 |
| 6/18/2021 | | @ | Bal | L | | 1 | 2 | 33 | 30 | .524 | 5-5 | L1 | 63 |
| 6/18/2021 | | | Sea | W | O'Neill, T | 3 | 2 | 34 | 30 | .531 | 6-4 | W1 | 64 |
| 6/19/2021 | | @ | Bal | L | | 0 | 13 | 34 | 31 | .523 | 5-5 | L1 | 65 |
| 6/19/2021 | | | Sea | L | | 7 | 11 | 34 | 32 | .515 | 4-6 | L2 | 66 |
| 6/21/2021 | | | Oak | W | | 1 | 0 | 35 | 32 | .522 | 5-5 | W1 | 67 |
| 6/21/2021 | | @ | TB | W | Kiermaier, K | 6 | 0 | 36 | 32 | .529 | 6-4 | W2 | 68 |
| 6/22/2021 | | | Oak | W | Hicks, A | 6 | 3 | 37 | 32 | .536 | 6-4 | W3 | 69 |
| 6/22/2021 | | @ | TB | W | Fisher, D | 5 | 3 | 38 | 32 | .543 | 7-3 | W4 | 70 |
| 6/23/2021 | | | Oak | W | Hicks, A | 1 | 0 | 39 | 32 | .549 | 7-3 | W5 | 71 |
| 6/23/2021 | | @ | TB | W | Fisher, D | 7 | 1 | 40 | 32 | .556 | 7-3 | W6 | 72 |
| 6/24/2021 | | | LAA | W | McNeil, J | 3 | 0 | 41 | 32 | .562 | 8-2 | W7 | 73 |
| 6/24/2021 | | @ | Tor | W | Anderson, B | 8 | 5 | 42 | 32 | .568 | 8-2 | W8 | 74 |
| 6/25/2021 | | | LAA | W | Cordero, F | 6 | 5 | 43 | 32 | .573 | 9-1 | W9 | 75 |
| 6/25/2021 | | @ | Tor | W | Perez, R | 3 | 2 | 44 | 32 | .579 | 10-0 | W10 | 76 |
| 6/26/2021 | | | LAA | W | Torres, G | 4 | 2 | 45 | 32 | .584 | 10-0 | W11 | 77 |
| 6/26/2021 | | @ | Tor | W | Rizzo, A | 7 | 3 | 46 | 32 | .590 | 10-0 | W12 | 78 |
| 6/28/2021 | | @ | Bos | L | | 0 | 1 | 46 | 33 | .582 | 9-1 | L1 | 79 |
| 6/28/2021 | | | Tex | W | Rizzo, A | 6 | 4 | 47 | 33 | .587 | 9-1 | W1 | 80 |
| 6/29/2021 | | @ | Bos | W | O'Neill, T | 11 | 8 | 48 | 33 | .593 | 9-1 | W2 | 81 |
| 6/29/2021 | | | Tex | W | Hicks, A | 13 | 10 | 49 | 33 | .598 | 9-1 | W3 | 82 |
| 6/30/2021 | | @ | Bos | L | | 3 | 8 | 49 | 34 | .590 | 8-2 | L1 | 83 |
| 6/30/2021 | | | Tex | W | McNeil, J | 16 | 5 | 50 | 34 | .595 | 8-2 | W1 | 84 |
| 7/15/2021 | | | Det | L | | 6 | 17 | 50 | 35 | .588 | 7-3 | L1 | 85 |
| 7/15/2021 | | @ | Cle | W | Anderson, B | 13 | 2 | 51 | 35 | .593 | 7-3 | W1 | 86 |
| 7/16/2021 | | | Det | W | Anderson, B | 7 | 6 | 52 | 35 | .598 | 7-3 | W2 | 87 |
| 7/16/2021 | | @ | Cle | W | O'Neill, T | 5 | 3 | 53 | 35 | .602 | 7-3 | W3 | 88 |
| 7/17/2021 | | | Det | W | Rizzo, A | 3 | 1 | 54 | 35 | .607 | 8-2 | W4 | 89 |
| 7/17/2021 | | @ | Cle | W | Anderson, B | 9 | 7 | 55 | 35 | .611 | 8-2 | W5 | 90 |
| 7/19/2021 | | | Min | W | O'Neill, T | 3 | 1 | 56 | 35 | .615 | 8-2 | W6 | 91 |
| 7/19/2021 | | @ | KC | W | Taylor, C | 6 | 1 | 57 | 35 | .620 | 8-2 | W7 | 92 |
| 7/20/2021 | | | Min | L | | 3 | 4 | 57 | 36 | .613 | 8-2 | L1 | 93 |
| 7/20/2021 | | @ | KC | W | Hedges, A | 4 | 0 | 58 | 36 | .617 | 8-2 | W1 | 94 |
| 7/21/2021 | | | Min | W | McNeil, J | 12 | 11 | 59 | 36 | .621 | 9-1 | W2 | 95 |
| 7/21/2021 | | @ | KC | W | Taylor, C | 6 | 5 | 60 | 36 | .625 | 9-1 | W3 | 96 |
| 7/22/2021 | | | KC | W | Diaz, Y | 5 | 1 | 61 | 36 | .629 | 9-1 | W4 | 97 |
| 7/22/2021 | | @ | Min | W | Taylor, C | 7 | 1 | 62 | 36 | .633 | 9-1 | W5 | 98 |
| 7/23/2021 | | | KC | W | Rizzo, A | 3 | 1 | 63 | 36 | .636 | 9-1 | W6 | 99 |
| 7/23/2021 | | @ | Min | W | Rizzo, A | 8 | 7 | 64 | 36 | .640 | 9-1 | W7 | 100 |
| 7/24/2021 | | | KC | W | Tucker, C | 4 | 3 | 65 | 36 | .644 | 9-1 | W8 | 101 |
| 7/24/2021 | | @ | Min | W | McNeil, J | 3 | 1 | 66 | 36 | .647 | 9-1 | W9 | 102 |
| 7/26/2021 | | | Cle | W | Diaz, Y | 7 | 3 | 67 | 36 | .650 | 10-0 | W10 | 103 |
| 7/26/2021 | | @ | Det | W | Taylor, C | 6 | 2 | 68 | 36 | .654 | 10-0 | W11 | 104 |
| 7/27/2021 | | | Cle | W | Taylor, C | 7 | 6 | 69 | 36 | .657 | 10-0 | W12 | 105 |
| 7/27/2021 | | @ | Det | L | | 3 | 5 | 69 | 37 | .651 | 9-1 | L1 | 106 |
| 7/28/2021 | | | Cle | W | McNeil, J | 9 | 7 | 70 | 37 | .654 | 9-1 | W1 | 107 |
| 7/28/2021 | | @ | Det | L | | 0 | 2 | 70 | 38 | .648 | 8-2 | L1 | 108 |
| 8/13/2021 | | | Bos | L | | 0 | 3 | 70 | 39 | .642 | 7-3 | L2 | 109 |
| 8/13/2021 | | @ | LAA | W | O'Neill, T | 5 | 4 | 71 | 39 | .645 | 7-3 | W1 | 110 |
| 8/14/2021 | | | Bos | L | | 0 | 5 | 71 | 40 | .640 | 6-4 | L1 | 111 |
| 8/14/2021 | | @ | LAA | L | | 5 | 7 | 71 | 41 | .634 | 5-5 | L2 | 112 |
| 8/15/2021 | | | Bos | L | | 1 | 6 | 71 | 42 | .628 | 4-6 | L3 | 113 |
| 8/15/2021 | | @ | LAA | L | | 0 | 2 | 71 | 43 | .623 | 3-7 | L4 | 114 |
| 8/16/2021 | | | NYY | L | | 0 | 2 | 71 | 44 | .617 | 2-8 | L5 | 115 |
| 8/16/2021 | | @ | Tex | W | Rizzo, A | 7 | 1 | 72 | 44 | .621 | 3-7 | W1 | 116 |
| 8/17/2021 | | | NYY | L | | 4 | 7 | 72 | 45 | .615 | 2-8 | L1 | 117 |
| 8/17/2021 | | @ | Tex | L | | 3 | 4 | 72 | 46 | .610 | 2-8 | L2 | 118 |
| 8/18/2021 | | | NYY | L | | 2 | 4 | 72 | 47 | .605 | 2-8 | L3 | 119 |
| 8/18/2021 | | @ | Tex | W | Anderson, B | 5 | 2 | 73 | 47 | .608 | 2-8 | W1 | 120 |
| 8/20/2021 | | | TB | W | O'Neill, T | 7 | 1 | 74 | 47 | .612 | 3-7 | W2 | 121 |
| 8/20/2021 | | @ | Sea | W | McNeil, J | 7 | 3 | 75 | 47 | .615 | 4-6 | W3 | 122 |
| 8/21/2021 | | | TB | W | Davis, K | 9 | 5 | 76 | 47 | .618 | 5-5 | W4 | 123 |
| 8/21/2021 | | @ | Sea | W | Taylor, C | 5 | 3 | 77 | 47 | .621 | 6-4 | W5 | 124 |
| 8/22/2021 | | | TB | W | O'Neill, T | 7 | 3 | 78 | 47 | .624 | 7-3 | W6 | 125 |
| 8/22/2021 | | @ | Sea | W | Anderson, B | 3 | 2 | 79 | 47 | .627 | 7-3 | W7 | 126 |
| 8/23/2021 | | @ | Hou | W | O'Neill, T | 10 | 4 | 80 | 47 | .630 | 8-2 | W8 | 127 |
| 8/23/2021 | | | Tor | W | O'Neill, T | 5 | 1 | 81 | 47 | .633 | 9-1 | W9 | 128 |
| 8/24/2021 | | @ | Hou | L | | 0 | 4 | 81 | 48 | .628 | 9-1 | L1 | 129 |
| 8/24/2021 | | | Tor | W | Taylor, C | 9 | 1 | 82 | 48 | .631 | 9-1 | W1 | 130 |
| 8/25/2021 | | @ | Hou | W | Taylor, C | 5 | 1 | 83 | 48 | .634 | 9-1 | W2 | 131 |
| 8/25/2021 | | | Tor | L | | 8 | 13 | 83 | 49 | .629 | 8-2 | L1 | 132 |
| 8/27/2021 | | | Bal | L | | 5 | 7 | 83 | 50 | .624 | 7-3 | L2 | 133 |
| 8/27/2021 | | @ | Oak | L | | 3 | 8 | 83 | 51 | .619 | 6-4 | L3 | 134 |
| 8/28/2021 | | | Bal | W | Rizzo, A | 4 | 3 | 84 | 51 | .622 | 6-4 | W1 | 135 |
| 8/28/2021 | | @ | Oak | L | | 2 | 6 | 84 | 52 | .618 | 5-5 | L1 | 136 |
| 8/29/2021 | | | Bal | W | Rizzo, A | 7 | 1 | 85 | 52 | .620 | 5-5 | W1 | 137 |
| 8/29/2021 | | @ | Oak | W | Rizzo, A | 2 | 1 | 86 | 52 | .623 | 5-5 | W2 | 138 |
| 9/13/2021 | | | Min | W | Rizzo, A | 12 | 1 | 87 | 52 | .626 | 6-4 | W3 | 139 |
| 9/13/2021 | | @ | KC | L | | 4 | 8 | 87 | 53 | .621 | 5-5 | L1 | 140 |
| 9/14/2021 | | | Min | W | Diaz, Y | 5 | 4 | 88 | 53 | .624 | 5-5 | W1 | 141 |
| 9/14/2021 | | @ | KC | W | | 6 | 3 | 89 | 53 | .627 | 6-4 | W2 | 142 |
| 9/15/2021 | | | Min | L | | 4 | 5 | 89 | 54 | .622 | 6-4 | L1 | 143 |
| 9/15/2021 | | @ | KC | W | Rizzo, A | 8 | 6 | 90 | 54 | .625 | 7-3 | W1 | 144 |
| 9/17/2021 | | | Cle | W | Anderson, B | 6 | 3 | 91 | 54 | .628 | 7-3 | W2 | 145 |
| 9/17/2021 | | @ | Det | W | Diaz, Y | 5 | 1 | 92 | 54 | .630 | 8-2 | W3 | 146 |
| 9/18/2021 | | | Cle | L | | 3 | 4 | 92 | 55 | .626 | 7-3 | L1 | 147 |
| 9/18/2021 | | @ | Det | L | | 1 | 2 | 92 | 56 | .622 | 6-4 | L2 | 148 |
| 9/19/2021 | | | Cle | W | Hicks, A | 21 | 10 | 93 | 56 | .624 | 6-4 | W1 | 149 |
| 9/19/2021 | | @ | Det | W | Cordero, F | 5 | 4 | 94 | 56 | .627 | 7-3 | W2 | 150 |
| 9/20/2021 | | | Det | W | Anderson, B | 7 | 4 | 95 | 56 | .629 | 7-3 | W3 | 151 |
| 9/20/2021 | | @ | Cle | W | McNeil, J | 4 | 2 | 96 | 56 | .632 | 7-3 | W4 | 152 |
| 9/21/2021 | | | Det | W | Hicks, A | 4 | 2 | 97 | 56 | .634 | 8-2 | W5 | 153 |
| 9/21/2021 | | @ | Cle | W | Davis, K | 11 | 4 | 98 | 56 | .636 | 8-2 | W6 | 154 |
| 9/22/2021 | | | Det | W | Hedges, A | 3 | 2 | 99 | 56 | .639 | 8-2 | W7 | 155 |
| 9/22/2021 | | @ | Cle | W | Stephenson, T | 11 | 2 | 100 | 56 | .641 | 8-2 | W8 | 156 |
| 9/24/2021 | | | KC | W | McNeil, J | 8 | 3 | 101 | 56 | .643 | 9-1 | W9 | 157 |
| 9/24/2021 | | @ | Min | W | Hicks, A | 10 | 4 | 102 | 56 | .646 | 10-0 | W10 | 158 |
| 9/25/2021 | | | KC | L | | 2 | 3 | 102 | 57 | .642 | 9-1 | L1 | 159 |
| 9/25/2021 | | @ | Min | W | Rizzo, A | 4 | 3 | 103 | 57 | .644 | 9-1 | W1 | 160 |
| 9/26/2021 | | | KC | W | McNeil, J | 5 | 2 | 104 | 57 | .646 | 9-1 | W2 | 161 |
| 9/26/2021 | | @ | Min | W | Hicks, A | 7 | 4 | 105 | 57 | .648 | 9-1 | W3 | 162 |