Team game results - 2021 Boston Red Sox
Regular season
| Primary |
| Date | # | | Opp | | Score | Inn | Starter | T | W/L | Save | Versus | T |
| 9/28/2009 | | @ | Bal | W | 9-4 | | | R | | | | R |
| 4/15/2021 | | | Tor | W | 10-4 | | Webb, L | R | Barlow, S | Kolarek, A | Lorenzen, M | R |
| 4/15/2021 | | @ | NYY | W | 3-1 | | Merryweather, J | R | Ramirez, E | Petit, Y | Lynn, L | R |
| 4/16/2021 | | | Tor | W | 12-1 | | Javier, C | R | Javier, C | | Newcomb, S | L |
| 4/16/2021 | | @ | NYY | L | 1-4 | | Webb, L | R | Webb, L | | Duffy, D | L |
| 4/17/2021 | | | Tor | W | 4-2 | | Kim, K | L | Kim, K | Melancon, M | Clarke, T | R |
| 4/17/2021 | | @ | NYY | L | 0-3 | | Kim, K | L | Kim, K | | Bundy, D | R |
| 4/19/2021 | | @ | Bal | W | 2-1 | | Plutko, A | R | Plutko, A | Yardley, E | Cahill, T | R |
| 4/19/2021 | | | TB | W | 4-3 | | Ynoa, H | R | Yardley, E | Melancon, M | Wright, K | R |
| 4/20/2021 | | @ | Bal | L | 0-2 | | Merryweather, J | R | Merryweather, J | | Turnbull, S | R |
| 4/20/2021 | | | TB | W | 3-2 | | Webb, L | R | Barlow, S | Melancon, M | Lopez, R | R |
| 4/21/2021 | | @ | Bal | W | 7-3 | | Webb, L | R | Webb, L | | Mills, A | R |
| 4/21/2021 | | | TB | W | 2-0 | | Javier, C | R | Javier, C | Petit, Y | Canning, G | R |
| 4/22/2021 | | | Bal | W | 5-2 | | Kim, K | L | Kim, K | Melancon, M | Mills, A | R |
| 4/22/2021 | | @ | TB | W | 9-2 | | Javier, C | R | Javier, C | | Anderson, B | L |
| 4/23/2021 | | | Bal | L | 5-7 | | Hudson, D | R | Hudson, D | | Cobb, A | R |
| 4/23/2021 | | @ | TB | W | 3-1 | | Kim, K | L | Kim, K | Melancon, M | Wright, K | R |
| 4/24/2021 | | | Bal | L | 1-6 | | Webb, L | R | Webb, L | | Urias, J | L |
| 4/24/2021 | | @ | TB | W | 4-3 | | Plutko, A | R | Melancon, M | | Canning, G | R |
| 4/26/2021 | | | NYY | L | 4-5 | | Ynoa, H | R | Ynoa, H | | Burnes, C | R |
| 4/26/2021 | | @ | Tor | W | 9-4 | | Webb, L | R | Shreve, C | | Velasquez, V | R |
| 4/27/2021 | | | NYY | L | 7-8 | | Javier, C | R | Yardley, E | | Duffy, D | L |
| 4/27/2021 | | @ | Tor | W | 8-4 | | Javier, C | R | Kolarek, A | Melancon, M | Brewer, C | R |
| 4/28/2021 | | | NYY | W | 3-0 | | Hudson, D | R | Hudson, D | Melancon, M | Lynn, L | R |
| 4/28/2021 | | @ | Tor | W | 12-3 | | Merryweather, J | R | Ramirez, E | | Newcomb, S | L |
| 5/13/2021 | | @ | Pit | W | 12-1 | | Merryweather, J | R | Barlow, S | | Senzatela, A | R |
| 5/13/2021 | | | Col | W | 11-7 | | Kim, K | L | Shreve, C | | Cole, G | R |
| 5/14/2021 | | @ | Pit | W | 2-1 | | Plutko, A | R | Ramirez, E | Yardley, E | Montgomery, J | L |
| 5/14/2021 | | | Col | L | 3-13 | | Hudson, D | R | Hudson, D | | Bieber, S | R |
| 5/15/2021 | | @ | Pit | W | 8-2 | | Hudson, D | R | Hudson, D | | Davies, Z | R |
| 5/15/2021 | | | Col | W | 7-2 | | Webb, L | R | Kolarek, A | | Wainwright, A | R |
| 5/17/2021 | | @ | Cin | W | 8-1 | | Javier, C | R | Javier, C | | Lyles, J | R |
| 5/17/2021 | | | SF | W | 6-5 | | Plutko, A | R | Melancon, M | | Thornton, T | R |
| 5/18/2021 | | @ | Cin | W | 13-5 | | Webb, L | R | Webb, L | | Kikuchi, Y | L |
| 5/18/2021 | | | SF | W | 7-2 | | Kim, K | L | Kim, K | | Rodon, C | L |
| 5/19/2021 | | @ | Cin | L | 3-8 | | Medina, A | R | Ramirez, E | | Plesac, Z | R |
| 5/19/2021 | | | SF | W | 3-2 | | Ynoa, H | R | Yardley, E | | Wheeler, Z | R |
| 5/21/2021 | | | SD | W | 10-0 | | Hudson, D | R | Hudson, D | | Gausman, K | R |
| 5/21/2021 | | @ | Mil | W | 3-1 | | Hudson, D | R | Barlow, S | Yardley, E | Richards, G | R |
| 5/22/2021 | | | SD | W | 6-5 | | Webb, L | R | Kolarek, A | Melancon, M | Perez, M | L |
| 5/22/2021 | | @ | Mil | W | 6-3 | | Javier, C | R | Ramirez, E | | Kershaw, C | L |
| 5/23/2021 | | | SD | L | 0-5 | | Kim, K | L | Kim, K | | Fiers, M | R |
| 5/23/2021 | | @ | Mil | W | 4-1 | | Webb, L | R | Webb, L | Barlow, S | Morton, C | R |
| 5/24/2021 | | @ | ChC | W | 6-5 | | Merryweather, J | R | Shreve, C | Melancon, M | Montas, F | R |
| 5/24/2021 | | | LAD | W | 5-3 | | Plutko, A | R | Kolarek, A | Melancon, M | Porcello, R | R |
| 5/25/2021 | | @ | ChC | L | 2-4 | | Plutko, A | R | Plutko, A | | Alzolay, A | R |
| 5/25/2021 | | | LAD | L | 2-7 | | Ynoa, H | R | Ynoa, H | | deGrom, J | R |
| 5/26/2021 | | @ | ChC | W | 9-6 | | Hudson, D | R | Kolarek, A | | Greinke, Z | R |
| 5/26/2021 | | | LAD | L | 3-7 | | Hudson, D | R | Hudson, D | | Williams, T | R |
| 5/28/2021 | | @ | StL | W | 2-0 | | Javier, C | R | Javier, C | Melancon, M | Heaney, A | L |
| 5/28/2021 | | | Ari | W | 5-4 | | Webb, L | R | Barlow, S | Melancon, M | Maeda, K | R |
| 5/29/2021 | | @ | StL | W | 6-3 | | Webb, L | R | Webb, L | Yardley, E | Ray, R | L |
| 5/29/2021 | | | Ari | L | 0-2 | | Kim, K | L | Kim, K | | Gallen, Z | R |
| 5/30/2021 | | @ | StL | W | 4-2 | | Medina, A | R | Medina, A | Kolarek, A | Paxton, J | L |
| 5/30/2021 | | | Ari | W | 6-5 | | Ynoa, H | R | Melancon, M | | Ryu, H | L |
| 6/14/2021 | | | Det | W | 9-8 | | Kim, K | L | Melancon, M | | Kittredge, A | R |
| 6/14/2021 | | @ | Sea | W | 7-0 | | Ynoa, H | R | Barlow, S | Ramirez, E | Minor, M | L |
| 6/15/2021 | | | Det | L | 3-6 | | Hudson, D | R | Hudson, D | | Marquez, G | R |
| 6/15/2021 | | @ | Sea | W | 6-0 | | Javier, C | R | Javier, C | | Glasnow, T | R |
| 6/16/2021 | | | Det | L | 5-6 | | Javier, C | R | Javier, C | | Bauer, T | R |
| 6/16/2021 | | @ | Sea | L | 0-1 | | Kim, K | L | Kim, K | | Skubal, T | L |
| 6/17/2021 | | @ | Hou | W | 6-0 | | Hudson, D | R | Hudson, D | | Hill, R | L |
| 6/17/2021 | | | Cle | W | 4-3 | | Plutko, A | R | Barlow, S | Melancon, M | Weber, R | R |
| 6/18/2021 | | @ | Hou | W | 10-5 | | Webb, L | R | Webb, L | | Gray, J | R |
| 6/18/2021 | | | Cle | W | 5-3 | | Webb, L | R | Webb, L | Melancon, M | Bielak, B | R |
| 6/19/2021 | | @ | Hou | L | 2-3 | | Ynoa, H | R | Ramirez, E | | Ponce de Leon, D | R |
| 6/19/2021 | | | Cle | W | 8-4 | | Kim, K | L | Kim, K | | Civale, A | R |
| 6/21/2021 | | | KC | W | 7-6 | | Hudson, D | R | Yardley, E | Melancon, M | Voth, A | R |
| 6/21/2021 | | @ | Oak | L | 1-4 | | Javier, C | R | Javier, C | | Fried, M | L |
| 6/22/2021 | | | KC | W | 7-1 | | Javier, C | R | Javier, C | Barlow, S | Singer, B | R |
| 6/22/2021 | | @ | Oak | L | 1-2 | | Hudson, D | R | Beeks, J | | Cueto, J | R |
| 6/23/2021 | | | KC | W | 13-7 | | Webb, L | R | Yardley, E | | Lindblom, J | R |
| 6/23/2021 | | @ | Oak | W | 4-1 | | Kim, K | L | Kim, K | Yardley, E | Scherzer, M | R |
| 6/24/2021 | | | Min | W | 7-0 | | Plutko, A | R | Plutko, A | | Kremer, D | R |
| 6/24/2021 | | @ | LAA | W | 3-2 | | Webb, L | R | Petit, Y | Melancon, M | Boyd, M | L |
| 6/25/2021 | | | Min | L | 2-3 | | Kim, K | L | Melancon, M | | Allard, K | L |
| 6/25/2021 | | @ | LAA | L | 2-3 | 11 | Ynoa, H | R | Yardley, E | | Darvish, Y | R |
| 6/26/2021 | | | Min | W | 8-0 | | Hudson, D | R | Hudson, D | | Nola, A | R |
| 6/26/2021 | | @ | LAA | W | 6-5 | | Javier, C | R | Javier, C | Merryweather, J | Yarbrough, R | L |
| 6/28/2021 | | | ChW | W | 1-0 | | Javier, C | R | Javier, C | Melancon, M | Tanaka, M | R |
| 6/28/2021 | | @ | Tex | W | 4-3 | | Hudson, D | R | Hudson, D | Melancon, M | Sanchez, A | R |
| 6/29/2021 | | | ChW | L | 8-11 | | Webb, L | R | Yardley, E | | Reyes, A | R |
| 6/29/2021 | | @ | Tex | W | 14-2 | | Webb, L | R | Webb, L | | Fulmer, M | R |
| 6/30/2021 | | | ChW | W | 8-3 | | Kim, K | L | Kim, K | | Eovaldi, N | R |
| 6/30/2021 | | @ | Tex | W | 5-4 | | Ynoa, H | R | Ramirez, E | Melancon, M | Stripling, R | R |
| 7/15/2021 | | @ | Bal | W | 12-0 | | Javier, C | R | Javier, C | | Turnbull, S | R |
| 7/15/2021 | | | TB | W | 3-2 | 11 | Webb, L | R | Petit, Y | | Canning, G | R |
| 7/16/2021 | | @ | Bal | W | 10-5 | | Merryweather, J | R | Shreve, C | | Mills, A | R |
| 7/16/2021 | | | TB | W | 6-2 | | Javier, C | R | Javier, C | Martin, C | Soroka, M | R |
| 7/17/2021 | | @ | Bal | L | 0-6 | | Webb, L | R | Webb, L | | Cobb, A | R |
| 7/17/2021 | | | TB | W | 7-2 | | Ynoa, H | R | Shreve, C | | Lopez, R | R |
| 7/19/2021 | | | NYY | L | 2-5 | | Kim, K | L | Kim, K | | Burnes, C | R |
| 7/19/2021 | | @ | Tor | W | 5-0 | | Kim, K | L | Kim, K | | Velasquez, V | R |
| 7/20/2021 | | | NYY | L | 1-4 | | Webb, L | R | Webb, L | | Duffy, D | L |
| 7/20/2021 | | @ | Tor | W | 10-8 | | Javier, C | R | Barlow, S | Martin, C | Roark, T | R |
| 7/21/2021 | | | NYY | W | 4-3 | | Javier, C | R | Kolarek, A | Melancon, M | Lynn, L | R |
| 7/21/2021 | | @ | Tor | W | 5-1 | | Merryweather, J | R | Ramirez, E | Kolarek, A | Brewer, C | R |
| 7/22/2021 | | | Tor | W | 11-3 | | Ynoa, H | R | Ynoa, H | Shreve, C | Miley, W | L |
| 7/22/2021 | | @ | NYY | L | 2-4 | | Plutko, A | R | Plutko, A | | Burnes, C | R |
| 7/23/2021 | | | Tor | W | 13-5 | | Hudson, D | R | Hudson, D | | Newcomb, S | L |
| 7/23/2021 | | @ | NYY | W | 5-4 | | Webb, L | R | Webb, L | Martin, C | Ponce, C | R |
| 7/24/2021 | | | Tor | W | 7-5 | | Webb, L | R | Webb, L | Melancon, M | Brewer, C | R |
| 7/24/2021 | | @ | NYY | L | 0-2 | | Kim, K | L | Kim, K | | Lynn, L | R |
| 7/26/2021 | | | Bal | W | 6-3 | | Kim, K | L | Martin, C | Melancon, M | Urias, J | L |
| 7/26/2021 | | @ | TB | W | 13-3 | | Merryweather, J | R | Barlow, S | | Lopez, R | R |
| 7/27/2021 | | | Bal | L | 3-4 | | Javier, C | R | Javier, C | | Mills, A | R |
| 7/27/2021 | | @ | TB | W | 11-2 | | Plutko, A | R | Ramirez, E | | Smeltzer, D | L |
| 7/28/2021 | | | Bal | L | 1-3 | | Hudson, D | R | Hudson, D | | Turnbull, S | R |
| 7/28/2021 | | @ | TB | L | 1-2 | | Javier, C | R | Kolarek, A | | Wright, K | R |
| 8/13/2021 | | | LAA | W | 5-2 | | Javier, C | R | Javier, C | Melancon, M | Bumgarner, M | L |
| 8/13/2021 | | @ | ChW | W | 3-0 | | Kim, K | L | Kim, K | Melancon, M | Keller, M | R |
| 8/14/2021 | | | LAA | L | 2-5 | | Webb, L | R | Webb, L | | Gomber, A | L |
| 8/14/2021 | | @ | ChW | W | 5-0 | | Hudson, D | R | Hudson, D | | Tanaka, M | R |
| 8/15/2021 | | | LAA | L | 6-11 | | Ynoa, H | R | Ynoa, H | | Toussaint, T | R |
| 8/15/2021 | | @ | ChW | W | 6-1 | | Javier, C | R | Barlow, S | | Freeland, K | L |
| 8/16/2021 | | | Tex | W | 6-5 | 12 | Kim, K | L | Shreve, C | | Thorpe, L | L |
| 8/16/2021 | | @ | Min | W | 4-0 | | Plutko, A | R | Ramirez, E | | Akin, K | L |
| 8/17/2021 | | | Tex | W | 31-2 | | Plutko, A | R | Plutko, A | | Stripling, R | R |
| 8/17/2021 | | @ | Min | W | 6-3 | | Webb, L | R | Barlow, S | Petit, Y | Mahle, T | R |
| 8/18/2021 | | | Tex | L | 2-4 | | Javier, C | R | Javier, C | | Sanchez, A | R |
| 8/18/2021 | | @ | Min | W | 8-1 | | Kim, K | L | Kim, K | | Nola, A | R |
| 8/20/2021 | | | Hou | L | 4-7 | | Webb, L | R | Webb, L | | Smyly, D | L |
| 8/20/2021 | | @ | Cle | W | 10-1 | | Plutko, A | R | Plutko, A | | Bielak, B | R |
| 8/21/2021 | | | Hou | W | 6-2 | | Ynoa, H | R | Ynoa, H | | Gray, J | R |
| 8/21/2021 | | @ | Cle | W | 10-4 | | Medina, A | R | Ramirez, E | | Castano, D | L |
| 8/22/2021 | | | Hou | W | 7-3 | | Plutko, A | R | Plutko, A | | Walker, T | R |
| 8/22/2021 | | @ | Cle | W | 15-5 | | Webb, L | R | Webb, L | | Shoemaker, M | R |
| 8/23/2021 | | | Sea | L | 2-6 | | Kim, K | L | Kim, K | | Keller, B | R |
| 8/23/2021 | | @ | Det | L | 1-2 | | Hudson, D | R | Melancon, M | | Cody, K | R |
| 8/24/2021 | | | Sea | L | 3-5 | | Javier, C | R | Kolarek, A | | Skubal, T | L |
| 8/24/2021 | | @ | Det | W | 6-1 | | Javier, C | R | Javier, C | Beeks, J | Marquez, G | R |
| 8/25/2021 | | | Sea | L | 1-7 | | Webb, L | R | Webb, L | | Glasnow, T | R |
| 8/25/2021 | | @ | Det | W | 7-4 | 13 | Kim, K | L | Merryweather, J | | Bauer, T | R |
| 8/27/2021 | | | Oak | W | 4-2 | 11 | Ynoa, H | R | Beeks, J | | Dobnak, R | R |
| 8/27/2021 | | @ | KC | W | 13-5 | | Medina, A | R | Ramirez, E | | Singer, B | R |
| 8/28/2021 | | | Oak | W | 2-0 | | Plutko, A | R | Plutko, A | Javier, C | Scherzer, M | R |
| 8/28/2021 | | @ | KC | L | 5-6 | | Hudson, D | R | Melancon, M | | Lindblom, J | R |
| 8/29/2021 | | | Oak | L | 5-6 | | Javier, C | R | Martin, C | | Fried, M | L |
| 8/29/2021 | | @ | KC | W | 7-5 | | Webb, L | R | Webb, L | Javier, C | Lamet, D | R |
| 9/13/2021 | | | NYY | L | 6-15 | | Ynoa, H | R | Ynoa, H | | May, D | R |
| 9/13/2021 | | @ | Tor | W | 9-2 | | Ynoa, H | R | Ramirez, E | | Clarke, T | R |
| 9/14/2021 | | | NYY | L | 2-3 | 12 | Hudson, D | R | Yardley, E | | Burnes, C | R |
| 9/14/2021 | | @ | Tor | W | 8-3 | | Webb, L | R | Shreve, C | Petit, Y | Newcomb, S | L |
| 9/15/2021 | | | NYY | L | 4-5 | | Plutko, A | R | Kaminsky, R | | Bundy, D | R |
| 9/15/2021 | | @ | Tor | L | 1-5 | | Hudson, D | R | Hudson, D | | Miley, W | L |
| 9/17/2021 | | | Bal | L | 4-7 | | Webb, L | R | Webb, L | | Urias, J | L |
| 9/17/2021 | | @ | TB | W | 6-3 | | Javier, C | R | Javier, C | Melancon, M | Soroka, M | R |
| 9/18/2021 | | | Bal | L | 0-6 | | Ynoa, H | R | Ynoa, H | | Curtiss, J | R |
| 9/18/2021 | | @ | TB | W | 5-1 | | Ynoa, H | R | Barlow, S | Yardley, E | Canning, G | R |
| 9/19/2021 | | | Bal | L | 2-3 | | Hudson, D | R | Hudson, D | | Cahill, T | R |
| 9/19/2021 | | @ | TB | W | 8-3 | | Plutko, A | R | Plutko, A | | Wright, K | R |
| 9/20/2021 | | @ | Bal | W | 6-5 | | Hudson, D | R | Petit, Y | Martin, C | Mills, A | R |
| 9/20/2021 | | | TB | W | 5-2 | | Plutko, A | R | Plutko, A | Melancon, M | Soroka, M | R |
| 9/21/2021 | | @ | Bal | L | 0-1 | | Webb, L | R | Webb, L | | Urias, J | L |
| 9/21/2021 | | | TB | W | 11-2 | | Javier, C | R | Javier, C | | Canning, G | R |
| 9/22/2021 | | @ | Bal | W | 3-2 | | Javier, C | R | Javier, C | Martin, C | Cahill, T | R |
| 9/22/2021 | | | TB | W | 11-3 | | Ynoa, H | R | Ynoa, H | | Anderson, B | L |
| 9/24/2021 | | | Tor | W | 12-4 | | Javier, C | R | Javier, C | Beeks, J | Roark, T | R |
| 9/24/2021 | | @ | NYY | L | 4-11 | | Ynoa, H | R | Ynoa, H | | Burnes, C | R |
| 9/25/2021 | | | Tor | L | 1-4 | | Webb, L | R | Webb, L | | Velasquez, V | R |
| 9/25/2021 | | @ | NYY | W | 5-0 | | Plutko, A | R | Plutko, A | | Lynn, L | R |
| 9/26/2021 | | | Tor | W | 5-1 | | Hudson, D | R | Hudson, D | | Newcomb, S | L |
| 9/26/2021 | | @ | NYY | W | 4-0 | | Hudson, D | R | Hudson, D | | Duffy, D | L |
| Other |
| | | | | | | | | Cumulative |
| Date | # | | Opp | | GWRBI | RF | RA | W | L | Pct | Last10 | Strk | Gm# |
| 9/28/2009 | | @ | Bal | W | | 9 | 4 | 112 | 51 | .687 | 8-2 | W4 | 163 |
| 4/15/2021 | | | Tor | W | Vogelbach, D | 10 | 4 | 1 | 0 | 1.000 | 1-0 | W1 | 1 |
| 4/15/2021 | | @ | NYY | W | Yastrzemski, M | 3 | 1 | 2 | 0 | 1.000 | 2-0 | W2 | 2 |
| 4/16/2021 | | | Tor | W | Slater, A | 12 | 1 | 3 | 0 | 1.000 | 3-0 | W3 | 3 |
| 4/16/2021 | | @ | NYY | L | | 1 | 4 | 3 | 1 | .750 | 3-1 | L1 | 4 |
| 4/17/2021 | | | Tor | W | Vogelbach, D | 4 | 2 | 4 | 1 | .800 | 4-1 | W1 | 5 |
| 4/17/2021 | | @ | NYY | L | | 0 | 3 | 4 | 2 | .667 | 4-2 | L1 | 6 |
| 4/19/2021 | | @ | Bal | W | Perez, S | 2 | 1 | 5 | 2 | .714 | 5-2 | W1 | 7 |
| 4/19/2021 | | | TB | W | Flores, W | 4 | 3 | 6 | 2 | .750 | 6-2 | W2 | 8 |
| 4/20/2021 | | @ | Bal | L | | 0 | 2 | 6 | 3 | .667 | 6-3 | L1 | 9 |
| 4/20/2021 | | | TB | W | Fletcher, D | 3 | 2 | 7 | 3 | .700 | 7-3 | W1 | 10 |
| 4/21/2021 | | @ | Bal | W | Arraez, L | 7 | 3 | 8 | 3 | .727 | 7-3 | W2 | 11 |
| 4/21/2021 | | | TB | W | Slater, A | 2 | 0 | 9 | 3 | .750 | 7-3 | W3 | 12 |
| 4/22/2021 | | | Bal | W | Perez, S | 5 | 2 | 10 | 3 | .769 | 7-3 | W4 | 13 |
| 4/22/2021 | | @ | TB | W | Yastrzemski, M | 9 | 2 | 11 | 3 | .786 | 8-2 | W5 | 14 |
| 4/23/2021 | | | Bal | L | | 5 | 7 | 11 | 4 | .733 | 7-3 | L1 | 15 |
| 4/23/2021 | | @ | TB | W | Ruf, D | 3 | 1 | 12 | 4 | .750 | 8-2 | W1 | 16 |
| 4/24/2021 | | | Bal | L | | 1 | 6 | 12 | 5 | .706 | 7-3 | L1 | 17 |
| 4/24/2021 | | @ | TB | W | Ruf, D | 4 | 3 | 13 | 5 | .722 | 7-3 | W1 | 18 |
| 4/26/2021 | | | NYY | L | | 4 | 5 | 13 | 6 | .684 | 7-3 | L1 | 19 |
| 4/26/2021 | | @ | Tor | W | Davis, J | 9 | 4 | 14 | 6 | .700 | 7-3 | W1 | 20 |
| 4/27/2021 | | | NYY | L | | 7 | 8 | 14 | 7 | .667 | 6-4 | L1 | 21 |
| 4/27/2021 | | @ | Tor | W | Flores, W | 8 | 4 | 15 | 7 | .682 | 6-4 | W1 | 22 |
| 4/28/2021 | | | NYY | W | Slater, A | 3 | 0 | 16 | 7 | .696 | 6-4 | W2 | 23 |
| 4/28/2021 | | @ | Tor | W | Slater, A | 12 | 3 | 17 | 7 | .708 | 6-4 | W3 | 24 |
| 5/13/2021 | | @ | Pit | W | Perez, S | 12 | 1 | 18 | 7 | .720 | 7-3 | W4 | 25 |
| 5/13/2021 | | | Col | W | Ruf, D | 11 | 7 | 19 | 7 | .731 | 7-3 | W5 | 26 |
| 5/14/2021 | | @ | Pit | W | Reynolds, B | 2 | 1 | 20 | 7 | .741 | 8-2 | W6 | 27 |
| 5/14/2021 | | | Col | L | | 3 | 13 | 20 | 8 | .714 | 7-3 | L1 | 28 |
| 5/15/2021 | | @ | Pit | W | Chavis, M | 8 | 2 | 21 | 8 | .724 | 8-2 | W1 | 29 |
| 5/15/2021 | | | Col | W | Davis, J | 7 | 2 | 22 | 8 | .733 | 8-2 | W2 | 30 |
| 5/17/2021 | | @ | Cin | W | Chavis, M | 8 | 1 | 23 | 8 | .742 | 9-1 | W3 | 31 |
| 5/17/2021 | | | SF | W | Reynolds, B | 6 | 5 | 24 | 8 | .750 | 9-1 | W4 | 32 |
| 5/18/2021 | | @ | Cin | W | Flores, W | 13 | 5 | 25 | 8 | .758 | 9-1 | W5 | 33 |
| 5/18/2021 | | | SF | W | Yastrzemski, M | 7 | 2 | 26 | 8 | .765 | 9-1 | W6 | 34 |
| 5/19/2021 | | @ | Cin | L | | 3 | 8 | 26 | 9 | .743 | 8-2 | L1 | 35 |
| 5/19/2021 | | | SF | W | Pinder, C | 3 | 2 | 27 | 9 | .750 | 8-2 | W1 | 36 |
| 5/21/2021 | | | SD | W | Perez, S | 10 | 0 | 28 | 9 | .757 | 8-2 | W2 | 37 |
| 5/21/2021 | | @ | Mil | W | Perez, S | 3 | 1 | 29 | 9 | .763 | 9-1 | W3 | 38 |
| 5/22/2021 | | | SD | W | Chavis, M | 6 | 5 | 30 | 9 | .769 | 9-1 | W4 | 39 |
| 5/22/2021 | | @ | Mil | W | Fletcher, D | 6 | 3 | 31 | 9 | .775 | 9-1 | W5 | 40 |
| 5/23/2021 | | | SD | L | | 0 | 5 | 31 | 10 | .756 | 8-2 | L1 | 41 |
| 5/23/2021 | | @ | Mil | W | Vogelbach, D | 4 | 1 | 32 | 10 | .762 | 8-2 | W1 | 42 |
| 5/24/2021 | | @ | ChC | W | Slater, A | 6 | 5 | 33 | 10 | .767 | 8-2 | W2 | 43 |
| 5/24/2021 | | | LAD | W | Ruf, D | 5 | 3 | 34 | 10 | .773 | 8-2 | W3 | 44 |
| 5/25/2021 | | @ | ChC | L | | 2 | 4 | 34 | 11 | .756 | 8-2 | L1 | 45 |
| 5/25/2021 | | | LAD | L | | 2 | 7 | 34 | 12 | .739 | 7-3 | L2 | 46 |
| 5/26/2021 | | @ | ChC | W | Ruf, D | 9 | 6 | 35 | 12 | .745 | 7-3 | W1 | 47 |
| 5/26/2021 | | | LAD | L | | 3 | 7 | 35 | 13 | .729 | 6-4 | L1 | 48 |
| 5/28/2021 | | @ | StL | W | Ruf, D | 2 | 0 | 36 | 13 | .735 | 6-4 | W1 | 49 |
| 5/28/2021 | | | Ari | W | | 5 | 4 | 37 | 13 | .740 | 6-4 | W2 | 50 |
| 5/29/2021 | | @ | StL | W | Fletcher, D | 6 | 3 | 38 | 13 | .745 | 7-3 | W3 | 51 |
| 5/29/2021 | | | Ari | L | | 0 | 2 | 38 | 14 | .731 | 6-4 | L1 | 52 |
| 5/30/2021 | | @ | StL | W | Tromp, C | 4 | 2 | 39 | 14 | .736 | 6-4 | W1 | 53 |
| 5/30/2021 | | | Ari | W | Fletcher, D | 6 | 5 | 40 | 14 | .741 | 6-4 | W2 | 54 |
| 6/14/2021 | | | Det | W | Perez, S | 9 | 8 | 41 | 14 | .745 | 7-3 | W3 | 55 |
| 6/14/2021 | | @ | Sea | W | Flores, W | 7 | 0 | 42 | 14 | .750 | 8-2 | W4 | 56 |
| 6/15/2021 | | | Det | L | | 3 | 6 | 42 | 15 | .737 | 7-3 | L1 | 57 |
| 6/15/2021 | | @ | Sea | W | Ruf, D | 6 | 0 | 43 | 15 | .741 | 8-2 | W1 | 58 |
| 6/16/2021 | | | Det | L | | 5 | 6 | 43 | 16 | .729 | 7-3 | L1 | 59 |
| 6/16/2021 | | @ | Sea | L | | 0 | 1 | 43 | 17 | .717 | 6-4 | L2 | 60 |
| 6/17/2021 | | @ | Hou | W | Ruf, D | 6 | 0 | 44 | 17 | .721 | 6-4 | W1 | 61 |
| 6/17/2021 | | | Cle | W | Perez, S | 4 | 3 | 45 | 17 | .726 | 7-3 | W2 | 62 |
| 6/18/2021 | | @ | Hou | W | Ruf, D | 10 | 5 | 46 | 17 | .730 | 7-3 | W3 | 63 |
| 6/18/2021 | | | Cle | W | Yastrzemski, M | 5 | 3 | 47 | 17 | .734 | 7-3 | W4 | 64 |
| 6/19/2021 | | @ | Hou | L | | 2 | 3 | 47 | 18 | .723 | 6-4 | L1 | 65 |
| 6/19/2021 | | | Cle | W | Ruf, D | 8 | 4 | 48 | 18 | .727 | 6-4 | W1 | 66 |
| 6/21/2021 | | | KC | W | Yastrzemski, M | 7 | 6 | 49 | 18 | .731 | 7-3 | W2 | 67 |
| 6/21/2021 | | @ | Oak | L | | 1 | 4 | 49 | 19 | .721 | 6-4 | L1 | 68 |
| 6/22/2021 | | | KC | W | Pinder, C | 7 | 1 | 50 | 19 | .725 | 7-3 | W1 | 69 |
| 6/22/2021 | | @ | Oak | L | | 1 | 2 | 50 | 20 | .714 | 7-3 | L1 | 70 |
| 6/23/2021 | | | KC | W | Sanchez, Y | 13 | 7 | 51 | 20 | .718 | 7-3 | W1 | 71 |
| 6/23/2021 | | @ | Oak | W | Reynolds, B | 4 | 1 | 52 | 20 | .722 | 7-3 | W2 | 72 |
| 6/24/2021 | | | Min | W | Fletcher, D | 7 | 0 | 53 | 20 | .726 | 7-3 | W3 | 73 |
| 6/24/2021 | | @ | LAA | W | Davis, J | 3 | 2 | 54 | 20 | .730 | 7-3 | W4 | 74 |
| 6/25/2021 | | | Min | L | | 2 | 3 | 54 | 21 | .720 | 7-3 | L1 | 75 |
| 6/25/2021 | | @ | LAA | L | | 2 | 3 | 54 | 22 | .711 | 6-4 | L2 | 76 |
| 6/26/2021 | | | Min | W | Perez, S | 8 | 0 | 55 | 22 | .714 | 6-4 | W1 | 77 |
| 6/26/2021 | | @ | LAA | W | Tromp, C | 6 | 5 | 56 | 22 | .718 | 7-3 | W2 | 78 |
| 6/28/2021 | | | ChW | W | Yastrzemski, M | 1 | 0 | 57 | 22 | .722 | 7-3 | W3 | 79 |
| 6/28/2021 | | @ | Tex | W | Chavis, M | 4 | 3 | 58 | 22 | .725 | 8-2 | W4 | 80 |
| 6/29/2021 | | | ChW | L | | 8 | 11 | 58 | 23 | .716 | 7-3 | L1 | 81 |
| 6/29/2021 | | @ | Tex | W | Davis, J | 14 | 2 | 59 | 23 | .720 | 7-3 | W1 | 82 |
| 6/30/2021 | | | ChW | W | Davis, J | 8 | 3 | 60 | 23 | .723 | 7-3 | W2 | 83 |
| 6/30/2021 | | @ | Tex | W | Perez, S | 5 | 4 | 61 | 23 | .726 | 7-3 | W3 | 84 |
| 7/15/2021 | | @ | Bal | W | Davis, J | 12 | 0 | 62 | 23 | .729 | 8-2 | W4 | 85 |
| 7/15/2021 | | | TB | W | Ruf, D | 3 | 2 | 63 | 23 | .733 | 9-1 | W5 | 86 |
| 7/16/2021 | | @ | Bal | W | Grossman, R | 10 | 5 | 64 | 23 | .736 | 9-1 | W6 | 87 |
| 7/16/2021 | | | TB | W | Arraez, L | 6 | 2 | 65 | 23 | .739 | 9-1 | W7 | 88 |
| 7/17/2021 | | @ | Bal | L | | 0 | 6 | 65 | 24 | .730 | 8-2 | L1 | 89 |
| 7/17/2021 | | | TB | W | Vogelbach, D | 7 | 2 | 66 | 24 | .733 | 8-2 | W1 | 90 |
| 7/19/2021 | | | NYY | L | | 2 | 5 | 66 | 25 | .725 | 8-2 | L1 | 91 |
| 7/19/2021 | | @ | Tor | W | Grossman, R | 5 | 0 | 67 | 25 | .728 | 8-2 | W1 | 92 |
| 7/20/2021 | | | NYY | L | | 1 | 4 | 67 | 26 | .720 | 7-3 | L1 | 93 |
| 7/20/2021 | | @ | Tor | W | Lavarnway, R | 10 | 8 | 68 | 26 | .723 | 7-3 | W1 | 94 |
| 7/21/2021 | | | NYY | W | Flores, W | 4 | 3 | 69 | 26 | .726 | 7-3 | W2 | 95 |
| 7/21/2021 | | @ | Tor | W | Yastrzemski, M | 5 | 1 | 70 | 26 | .729 | 7-3 | W3 | 96 |
| 7/22/2021 | | | Tor | W | Fletcher, D | 11 | 3 | 71 | 26 | .732 | 7-3 | W4 | 97 |
| 7/22/2021 | | @ | NYY | L | | 2 | 4 | 71 | 27 | .724 | 6-4 | L1 | 98 |
| 7/23/2021 | | | Tor | W | Slater, A | 13 | 5 | 72 | 27 | .727 | 7-3 | W1 | 99 |
| 7/23/2021 | | @ | NYY | W | Vogelbach, D | 5 | 4 | 73 | 27 | .730 | 7-3 | W2 | 100 |
| 7/24/2021 | | | Tor | W | Flores, W | 7 | 5 | 74 | 27 | .733 | 8-2 | W3 | 101 |
| 7/24/2021 | | @ | NYY | L | | 0 | 2 | 74 | 28 | .725 | 7-3 | L1 | 102 |
| 7/26/2021 | | | Bal | W | Yastrzemski, M | 6 | 3 | 75 | 28 | .728 | 8-2 | W1 | 103 |
| 7/26/2021 | | @ | TB | W | Lavarnway, R | 13 | 3 | 76 | 28 | .731 | 8-2 | W2 | 104 |
| 7/27/2021 | | | Bal | L | | 3 | 4 | 76 | 29 | .724 | 7-3 | L1 | 105 |
| 7/27/2021 | | @ | TB | W | Ruf, D | 11 | 2 | 77 | 29 | .726 | 7-3 | W1 | 106 |
| 7/28/2021 | | | Bal | L | | 1 | 3 | 77 | 30 | .720 | 6-4 | L1 | 107 |
| 7/28/2021 | | @ | TB | L | | 1 | 2 | 77 | 31 | .713 | 6-4 | L2 | 108 |
| 8/13/2021 | | | LAA | W | Chavis, M | 5 | 2 | 78 | 31 | .716 | 6-4 | W1 | 109 |
| 8/13/2021 | | @ | ChW | W | Grossman, R | 3 | 0 | 79 | 31 | .718 | 6-4 | W2 | 110 |
| 8/14/2021 | | | LAA | L | | 2 | 5 | 79 | 32 | .712 | 5-5 | L1 | 111 |
| 8/14/2021 | | @ | ChW | W | Ruf, D | 5 | 0 | 80 | 32 | .714 | 6-4 | W1 | 112 |
| 8/15/2021 | | | LAA | L | | 6 | 11 | 80 | 33 | .708 | 5-5 | L1 | 113 |
| 8/15/2021 | | @ | ChW | W | Fletcher, D | 6 | 1 | 81 | 33 | .711 | 5-5 | W1 | 114 |
| 8/16/2021 | | | Tex | W | Chavis, M | 6 | 5 | 82 | 33 | .713 | 6-4 | W2 | 115 |
| 8/16/2021 | | @ | Min | W | Fletcher, D | 4 | 0 | 83 | 33 | .716 | 6-4 | W3 | 116 |
| 8/17/2021 | | | Tex | W | Perez, S | 31 | 2 | 84 | 33 | .718 | 7-3 | W4 | 117 |
| 8/17/2021 | | @ | Min | W | Flores, W | 6 | 3 | 85 | 33 | .720 | 8-2 | W5 | 118 |
| 8/18/2021 | | | Tex | L | | 2 | 4 | 85 | 34 | .714 | 7-3 | L1 | 119 |
| 8/18/2021 | | @ | Min | W | | 8 | 1 | 86 | 34 | .717 | 7-3 | W1 | 120 |
| 8/20/2021 | | | Hou | L | | 4 | 7 | 86 | 35 | .711 | 7-3 | L1 | 121 |
| 8/20/2021 | | @ | Cle | W | Grossman, R | 10 | 1 | 87 | 35 | .713 | 7-3 | W1 | 122 |
| 8/21/2021 | | | Hou | W | Perez, S | 6 | 2 | 88 | 35 | .715 | 8-2 | W2 | 123 |
| 8/21/2021 | | @ | Cle | W | Tromp, C | 10 | 4 | 89 | 35 | .718 | 8-2 | W3 | 124 |
| 8/22/2021 | | | Hou | W | Vogelbach, D | 7 | 3 | 90 | 35 | .720 | 8-2 | W4 | 125 |
| 8/22/2021 | | @ | Cle | W | Vogelbach, D | 15 | 5 | 91 | 35 | .722 | 8-2 | W5 | 126 |
| 8/23/2021 | | | Sea | L | | 2 | 6 | 91 | 36 | .717 | 7-3 | L1 | 127 |
| 8/23/2021 | | @ | Det | L | | 1 | 2 | 91 | 37 | .711 | 6-4 | L2 | 128 |
| 8/24/2021 | | | Sea | L | | 3 | 5 | 91 | 38 | .705 | 6-4 | L3 | 129 |
| 8/24/2021 | | @ | Det | W | Ruf, D | 6 | 1 | 92 | 38 | .708 | 6-4 | W1 | 130 |
| 8/25/2021 | | | Sea | L | | 1 | 7 | 92 | 39 | .702 | 6-4 | L1 | 131 |
| 8/25/2021 | | @ | Det | W | Perez, S | 7 | 4 | 93 | 39 | .705 | 6-4 | W1 | 132 |
| 8/27/2021 | | | Oak | W | Perez, S | 4 | 2 | 94 | 39 | .707 | 6-4 | W2 | 133 |
| 8/27/2021 | | @ | KC | W | Davis, J | 13 | 5 | 95 | 39 | .709 | 6-4 | W3 | 134 |
| 8/28/2021 | | | Oak | W | Vogelbach, D | 2 | 0 | 96 | 39 | .711 | 6-4 | W4 | 135 |
| 8/28/2021 | | @ | KC | L | | 5 | 6 | 96 | 40 | .706 | 5-5 | L1 | 136 |
| 8/29/2021 | | | Oak | L | | 5 | 6 | 96 | 41 | .701 | 5-5 | L2 | 137 |
| 8/29/2021 | | @ | KC | W | Yastrzemski, M | 7 | 5 | 97 | 41 | .703 | 6-4 | W1 | 138 |
| 9/13/2021 | | | NYY | L | | 6 | 15 | 97 | 42 | .698 | 6-4 | L1 | 139 |
| 9/13/2021 | | @ | Tor | W | Arraez, L | 9 | 2 | 98 | 42 | .700 | 6-4 | W1 | 140 |
| 9/14/2021 | | | NYY | L | | 2 | 3 | 98 | 43 | .695 | 6-4 | L1 | 141 |
| 9/14/2021 | | @ | Tor | W | Tromp, C | 8 | 3 | 99 | 43 | .697 | 6-4 | W1 | 142 |
| 9/15/2021 | | | NYY | L | | 4 | 5 | 99 | 44 | .692 | 5-5 | L1 | 143 |
| 9/15/2021 | | @ | Tor | L | | 1 | 5 | 99 | 45 | .688 | 4-6 | L2 | 144 |
| 9/17/2021 | | | Bal | L | | 4 | 7 | 99 | 46 | .683 | 3-7 | L3 | 145 |
| 9/17/2021 | | @ | TB | W | Flores, W | 6 | 3 | 100 | 46 | .685 | 4-6 | W1 | 146 |
| 9/18/2021 | | | Bal | L | | 0 | 6 | 100 | 47 | .680 | 4-6 | L1 | 147 |
| 9/18/2021 | | @ | TB | W | Grossman, R | 5 | 1 | 101 | 47 | .682 | 4-6 | W1 | 148 |
| 9/19/2021 | | | Bal | L | | 2 | 3 | 101 | 48 | .678 | 4-6 | L1 | 149 |
| 9/19/2021 | | @ | TB | W | Flores, W | 8 | 3 | 102 | 48 | .680 | 4-6 | W1 | 150 |
| 9/20/2021 | | @ | Bal | W | Ruf, D | 6 | 5 | 103 | 48 | .682 | 5-5 | W2 | 151 |
| 9/20/2021 | | | TB | W | Davis, J | 5 | 2 | 104 | 48 | .684 | 5-5 | W3 | 152 |
| 9/21/2021 | | @ | Bal | L | | 0 | 1 | 104 | 49 | .680 | 5-5 | L1 | 153 |
| 9/21/2021 | | | TB | W | Pinder, C | 11 | 2 | 105 | 49 | .682 | 6-4 | W1 | 154 |
| 9/22/2021 | | @ | Bal | W | Davis, J | 3 | 2 | 106 | 49 | .684 | 7-3 | W2 | 155 |
| 9/22/2021 | | | TB | W | Slater, A | 11 | 3 | 107 | 49 | .686 | 7-3 | W3 | 156 |
| 9/24/2021 | | | Tor | W | Yastrzemski, M | 12 | 4 | 108 | 49 | .688 | 8-2 | W4 | 157 |
| 9/24/2021 | | @ | NYY | L | | 4 | 11 | 108 | 50 | .684 | 7-3 | L1 | 158 |
| 9/25/2021 | | | Tor | L | | 1 | 4 | 108 | 51 | .679 | 7-3 | L2 | 159 |
| 9/25/2021 | | @ | NYY | W | Ruf, D | 5 | 0 | 109 | 51 | .681 | 7-3 | W1 | 160 |
| 9/26/2021 | | | Tor | W | Flores, W | 5 | 1 | 110 | 51 | .683 | 7-3 | W2 | 161 |
| 9/26/2021 | | @ | NYY | W | Flores, W | 4 | 0 | 111 | 51 | .685 | 7-3 | W3 | 162 |