Team game results - 2021 Baltimore Orioles
Regular season
| Primary |
| Date | # | | Opp | | Score | Inn | Starter | T | W/L | Save | Versus | T |
| 9/28/2009 | | | Bos | L | 4-9 | | | R | | | | R |
| 4/15/2021 | | | NYY | W | 6-5 | 13 | Turnbull, S | R | Holland, G | | Lynn, L | R |
| 4/15/2021 | | @ | TB | W | 4-0 | | Curtiss, J | R | Hendriks, L | | Canning, G | R |
| 4/16/2021 | | | NYY | W | 2-0 | | Mills, A | R | Mills, A | Hahn, J | Burnes, C | R |
| 4/16/2021 | | @ | TB | W | 18-0 | | Mills, A | R | Mills, A | | Smeltzer, D | L |
| 4/17/2021 | | | NYY | W | 9-4 | | Cobb, A | R | Cobb, A | Rodriguez, J | May, D | R |
| 4/17/2021 | | @ | TB | W | 12-7 | | Cobb, A | R | Cobb, A | | Anderson, B | L |
| 4/19/2021 | | | Bos | L | 1-2 | | Cahill, T | R | Cahill, T | | Plutko, A | R |
| 4/19/2021 | | @ | Tor | L | 2-3 | | Urias, J | L | Hahn, J | | Velasquez, V | R |
| 4/20/2021 | | | Bos | W | 2-0 | | Turnbull, S | R | Turnbull, S | Hendriks, L | Merryweather, J | R |
| 4/20/2021 | | @ | Tor | W | 14-4 | | Cahill, T | R | Herget, J | | Roark, T | R |
| 4/21/2021 | | | Bos | L | 3-7 | | Mills, A | R | Mills, A | | Webb, L | R |
| 4/21/2021 | | @ | Tor | W | 7-0 | | Turnbull, S | R | Turnbull, S | Holland, G | Brewer, C | R |
| 4/22/2021 | | | Tor | L | 1-4 | | Cobb, A | R | Cobb, A | | Roark, T | R |
| 4/22/2021 | | @ | Bos | L | 2-5 | | Mills, A | R | Mills, A | | Kim, K | L |
| 4/23/2021 | | | Tor | L | 10-12 | | Urias, J | L | Urias, J | | Clarke, T | R |
| 4/23/2021 | | @ | Bos | W | 7-5 | | Cobb, A | R | Cobb, A | Hendriks, L | Hudson, D | R |
| 4/24/2021 | | | Tor | W | 4-1 | | Turnbull, S | R | Turnbull, S | Hendriks, L | Velasquez, V | R |
| 4/24/2021 | | @ | Bos | W | 6-1 | | Urias, J | L | Urias, J | | Webb, L | R |
| 4/26/2021 | | | TB | W | 6-4 | | Cahill, T | R | Curtiss, J | Hendriks, L | Lopez, R | R |
| 4/26/2021 | | @ | NYY | L | 1-2 | 10 | Turnbull, S | R | Curtiss, J | | May, D | R |
| 4/27/2021 | | | TB | W | 18-9 | | Mills, A | R | Mills, A | | Canning, G | R |
| 4/27/2021 | | @ | NYY | W | 5-2 | | Cahill, T | R | Cahill, T | Hendriks, L | Duffy, D | L |
| 4/28/2021 | | | TB | W | 8-4 | | Urias, J | L | Urias, J | | Smeltzer, D | L |
| 4/28/2021 | | @ | NYY | W | 2-0 | 12 | Mills, A | R | Hunter, T | | Burnes, C | R |
| 5/13/2021 | | @ | Cin | W | 9-1 | | Cobb, A | R | Cobb, A | | Kikuchi, Y | L |
| 5/13/2021 | | | LAD | W | 5-3 | | Cobb, A | R | Cobb, A | Hendriks, L | deGrom, J | R |
| 5/14/2021 | | @ | Cin | L | 3-10 | | Turnbull, S | R | Turnbull, S | | Woodruff, B | R |
| 5/14/2021 | | | LAD | L | 3-6 | | Turnbull, S | R | Turnbull, S | | Williams, T | R |
| 5/15/2021 | | @ | Cin | W | 7-6 | | Mills, A | R | Mills, A | Hendriks, L | Berrios, J | R |
| 5/15/2021 | | | LAD | L | 3-4 | | Mills, A | R | Mills, A | | Lopez, P | R |
| 5/17/2021 | | | Ari | W | 7-1 | | Cahill, T | R | Curtiss, J | Holland, G | Maeda, K | R |
| 5/17/2021 | | @ | Mil | L | 3-9 | | Urias, J | L | Urias, J | | Gonsolin, T | R |
| 5/18/2021 | | | Ari | L | 0-1 | | Cobb, A | R | Cobb, A | | Gallen, Z | R |
| 5/18/2021 | | @ | Mil | W | 3-2 | 15 | Cahill, T | R | Hendriks, L | Herget, J | Morton, C | R |
| 5/19/2021 | | | Ari | L | 1-4 | | Urias, J | L | Urias, J | | Ryu, H | L |
| 5/19/2021 | | @ | Mil | L | 1-4 | | Cobb, A | R | Cobb, A | | Brault, S | L |
| 5/21/2021 | | @ | ChC | W | 12-8 | | Turnbull, S | R | Curtiss, J | | Greinke, Z | R |
| 5/21/2021 | | | Col | L | 1-8 | | Turnbull, S | R | Turnbull, S | | Bieber, S | R |
| 5/22/2021 | | @ | ChC | W | 1-0 | | Mills, A | R | Rodriguez, J | Hunter, T | Keuchel, D | L |
| 5/22/2021 | | | Col | W | 6-2 | | Mills, A | R | Mills, A | Holland, G | Means, J | L |
| 5/23/2021 | | @ | ChC | L | 2-5 | | Urias, J | L | Urias, J | | Happ, J | L |
| 5/23/2021 | | | Col | L | 3-8 | | Cobb, A | R | Cobb, A | | Wainwright, A | R |
| 5/24/2021 | | @ | StL | W | 8-2 | | Cahill, T | R | Hahn, J | Hendriks, L | Paxton, J | L |
| 5/24/2021 | | | SF | W | 5-0 | | Cahill, T | R | Cahill, T | | Rodon, C | L |
| 5/25/2021 | | @ | StL | W | 8-5 | | Cobb, A | R | Cobb, A | Hendriks, L | Harvey, M | R |
| 5/25/2021 | | | SF | W | 5-2 | | Urias, J | L | Urias, J | Hendriks, L | Wheeler, Z | R |
| 5/26/2021 | | @ | StL | W | 5-1 | | Turnbull, S | R | Turnbull, S | | Carrasco, C | R |
| 5/26/2021 | | | SF | W | 4-3 | | Turnbull, S | R | Rodriguez, J | Hahn, J | Peterson, D | L |
| 5/28/2021 | | @ | Pit | W | 6-5 | | Mills, A | R | Rodriguez, J | Curtiss, J | Davies, Z | R |
| 5/28/2021 | | | SD | W | 3-2 | | Mills, A | R | Mills, A | Hendriks, L | Perez, M | L |
| 5/29/2021 | | @ | Pit | W | 10-4 | 10 | Urias, J | L | Hahn, J | | Senzatela, A | R |
| 5/29/2021 | | | SD | L | 2-4 | | Cobb, A | R | Rodriguez, J | | Giolito, L | R |
| 5/30/2021 | | @ | Pit | W | 10-4 | | Cahill, T | R | Cahill, T | Hendriks, L | McCullers, L | R |
| 5/30/2021 | | | SD | L | 0-3 | | Urias, J | L | Urias, J | | Fiers, M | R |
| 6/14/2021 | | @ | Hou | W | 5-2 | | Mills, A | R | Holland, G | Hendriks, L | Ponce de Leon, D | R |
| 6/14/2021 | | | Min | W | 8-4 | | Turnbull, S | R | Turnbull, S | | Allard, K | L |
| 6/15/2021 | | @ | Hou | W | 5-2 | | Cobb, A | R | Cobb, A | Hendriks, L | Walker, T | R |
| 6/15/2021 | | | Min | L | 3-7 | | Mills, A | R | Mills, A | | Nola, A | R |
| 6/16/2021 | | @ | Hou | L | 2-3 | | Cahill, T | R | Rodriguez, J | | Dunn, J | R |
| 6/16/2021 | | | Min | W | 8-6 | | Cobb, A | R | Cobb, A | Hendriks, L | Mahle, T | R |
| 6/17/2021 | | | ChW | L | 1-5 | | Cahill, T | R | Cahill, T | | Tanaka, M | R |
| 6/17/2021 | | @ | Oak | W | 3-0 | | Turnbull, S | R | Rodriguez, J | Hendriks, L | Dobnak, R | R |
| 6/18/2021 | | | ChW | W | 2-1 | | Urias, J | L | Urias, J | Hendriks, L | Eovaldi, N | R |
| 6/18/2021 | | @ | Oak | W | 3-0 | | Urias, J | L | Urias, J | | Scherzer, M | R |
| 6/19/2021 | | | ChW | W | 13-0 | | Turnbull, S | R | Turnbull, S | | Freeland, K | L |
| 6/19/2021 | | @ | Oak | W | 9-5 | | Mills, A | R | Mills, A | Curtiss, J | Anderson, T | L |
| 6/21/2021 | | | Det | L | 3-4 | | Mills, A | R | Mills, A | | Marquez, G | R |
| 6/21/2021 | | @ | LAA | L | 2-3 | | Cobb, A | R | Cobb, A | | Yarbrough, R | L |
| 6/22/2021 | | | Det | L | 3-7 | | Cobb, A | R | Cobb, A | | Parker, B | R |
| 6/22/2021 | | @ | LAA | W | 10-0 | | Cahill, T | R | Rodriguez, J | Herget, J | Gomber, A | L |
| 6/23/2021 | | | Det | L | 3-7 | | Urias, J | L | Urias, J | | Lester, J | L |
| 6/23/2021 | | @ | LAA | W | 7-4 | | Turnbull, S | R | Turnbull, S | | Pineda, M | R |
| 6/24/2021 | | | Cle | W | 5-2 | | Cahill, T | R | Curtiss, J | Hendriks, L | Weber, R | R |
| 6/24/2021 | | @ | Tex | W | 3-0 | | Urias, J | L | Urias, J | Hendriks, L | Teheran, J | R |
| 6/25/2021 | | | Cle | W | 4-3 | 13 | Turnbull, S | R | Hahn, J | | Civale, A | R |
| 6/25/2021 | | @ | Tex | W | 8-2 | | Mills, A | R | Mills, A | | Stripling, R | R |
| 6/26/2021 | | | Cle | W | 6-3 | | Mills, A | R | Hunter, T | | Keller, B | R |
| 6/26/2021 | | @ | Tex | W | 8-5 | | Cobb, A | R | Cobb, A | | Thorpe, L | L |
| 6/28/2021 | | | KC | W | 3-2 | | Cobb, A | R | Cobb, A | Hendriks, L | Singer, B | R |
| 6/28/2021 | | @ | Sea | W | 10-5 | | Cahill, T | R | Holland, G | | Skubal, T | L |
| 6/29/2021 | | | KC | W | 5-3 | | Urias, J | L | Urias, J | | Lindblom, J | R |
| 6/29/2021 | | @ | Sea | L | 3-4 | | Turnbull, S | R | Hunter, T | | Fedde, E | R |
| 6/30/2021 | | | KC | W | 18-2 | | Turnbull, S | R | Turnbull, S | | Rogers, T | L |
| 6/30/2021 | | @ | Sea | W | 8-2 | | Urias, J | L | Urias, J | | Minor, M | L |
| 7/15/2021 | | | Bos | L | 0-12 | | Turnbull, S | R | Turnbull, S | | Javier, C | R |
| 7/15/2021 | | @ | Tor | W | 9-3 | | Lopez, J | R | Lopez, J | Hahn, J | Roark, T | R |
| 7/16/2021 | | | Bos | L | 5-10 | | Mills, A | R | Holland, G | | Merryweather, J | R |
| 7/16/2021 | | @ | Tor | W | 8-1 | | Mills, A | R | Mills, A | | Brewer, C | R |
| 7/17/2021 | | | Bos | W | 6-0 | | Cobb, A | R | Cobb, A | | Webb, L | R |
| 7/17/2021 | | @ | Tor | W | 11-3 | | Urias, J | L | Urias, J | | Clarke, T | R |
| 7/19/2021 | | | TB | W | 6-5 | | Lopez, J | R | Hendriks, L | | Smeltzer, D | L |
| 7/19/2021 | | @ | NYY | L | 5-12 | | Cobb, A | R | Cobb, A | | Duffy, D | L |
| 7/20/2021 | | | TB | L | 2-7 | | Turnbull, S | R | Turnbull, S | | Anderson, B | L |
| 7/20/2021 | | @ | NYY | L | 2-4 | | Turnbull, S | R | Turnbull, S | | Lynn, L | R |
| 7/21/2021 | | | TB | W | 16-1 | | Mills, A | R | Mills, A | | Canning, G | R |
| 7/21/2021 | | @ | NYY | W | 5-4 | | Lopez, J | R | Nelson, N | | Bundy, D | R |
| 7/22/2021 | | | NYY | W | 7-2 | | Cobb, A | R | Hahn, J | | Bundy, D | R |
| 7/22/2021 | | @ | TB | W | 8-0 | | Mills, A | R | Mills, A | | Anderson, C | R |
| 7/23/2021 | | | NYY | L | 3-5 | 13 | Urias, J | L | Herget, J | | May, D | R |
| 7/23/2021 | | @ | TB | W | 4-3 | | Cobb, A | R | Cobb, A | Hendriks, L | Wright, K | R |
| 7/24/2021 | | | NYY | W | 2-0 | | Turnbull, S | R | Turnbull, S | Hunter, T | Burnes, C | R |
| 7/24/2021 | | @ | TB | W | 4-3 | | Lopez, J | R | Hahn, J | Hendriks, L | Canning, G | R |
| 7/26/2021 | | | Tor | W | 10-3 | | Lopez, J | R | Holland, G | | Velasquez, V | R |
| 7/26/2021 | | @ | Bos | L | 3-6 | | Urias, J | L | Urias, J | | Kim, K | L |
| 7/27/2021 | | | Tor | W | 2-1 | | Mills, A | R | Herget, J | | Lorenzen, M | R |
| 7/27/2021 | | @ | Bos | W | 4-3 | | Mills, A | R | Hahn, J | Nelson, N | Javier, C | R |
| 7/28/2021 | | | Tor | W | 7-1 | | Urias, J | L | Urias, J | | Newcomb, S | L |
| 7/28/2021 | | @ | Bos | W | 3-1 | | Turnbull, S | R | Turnbull, S | Nelson, N | Hudson, D | R |
| 8/13/2021 | | | Sea | W | 3-2 | | Turnbull, S | R | Hendriks, L | | Keller, B | R |
| 8/13/2021 | | @ | Min | L | 4-15 | | Turnbull, S | R | Turnbull, S | | Nola, A | R |
| 8/14/2021 | | | Sea | L | 4-7 | | Mills, A | R | Mills, A | | Glasnow, T | R |
| 8/14/2021 | | @ | Min | W | 8-2 | | Urias, J | L | Urias, J | | Allard, K | L |
| 8/15/2021 | | | Sea | W | 3-0 | | Cobb, A | R | Cobb, A | Hendriks, L | Fedde, E | R |
| 8/15/2021 | | @ | Min | W | 9-4 | | Cobb, A | R | Cobb, A | | Musgrove, J | R |
| 8/16/2021 | | | Oak | W | 4-1 | | Cobb, A | R | Holland, G | Hendriks, L | Scherzer, M | R |
| 8/16/2021 | | @ | Cle | W | 14-3 | | Mills, A | R | Mills, A | | Houck, T | R |
| 8/17/2021 | | | Oak | L | 0-1 | | Urias, J | L | Urias, J | | Cueto, J | R |
| 8/17/2021 | | @ | Cle | W | 3-1 | 11 | Lopez, J | R | Hunter, T | | Shoemaker, M | R |
| 8/18/2021 | | | Oak | W | 5-4 | 10 | Turnbull, S | R | Hendriks, L | | Fried, M | L |
| 8/18/2021 | | @ | Cle | W | 7-4 | | Turnbull, S | R | Herget, J | Nelson, N | Civale, A | R |
| 8/20/2021 | | | LAA | W | 8-6 | | Mills, A | R | Hahn, J | Hendriks, L | Gomber, A | L |
| 8/20/2021 | | @ | Det | L | 2-4 | | Urias, J | L | Urias, J | | Bauer, T | R |
| 8/21/2021 | | | LAA | L | 2-6 | 15 | Cobb, A | R | Nelson, N | | Toussaint, T | R |
| 8/21/2021 | | @ | Det | W | 7-2 | | Cobb, A | R | Cobb, A | | Flaherty, J | R |
| 8/22/2021 | | | LAA | W | 4-3 | | Urias, J | L | Urias, J | Nelson, N | Darvish, Y | R |
| 8/22/2021 | | @ | Det | W | 17-6 | | Mills, A | R | Hendriks, L | | Lester, J | L |
| 8/23/2021 | | | Tex | W | 7-3 | | Lopez, J | R | Lopez, J | | Thorpe, L | L |
| 8/23/2021 | | @ | KC | W | 12-2 | | Lopez, J | R | Lopez, J | | Arrieta, J | R |
| 8/24/2021 | | | Tex | W | 15-2 | | Turnbull, S | R | Turnbull, S | | Sanchez, A | R |
| 8/24/2021 | | @ | KC | W | 8-6 | | Turnbull, S | R | Hunter, T | | Lamet, D | R |
| 8/25/2021 | | | Tex | W | 7-1 | | Mills, A | R | Mills, A | | Teheran, J | R |
| 8/25/2021 | | @ | KC | W | 4-3 | | Urias, J | L | Urias, J | Crick, K | Voth, A | R |
| 8/27/2021 | | | Hou | W | 4-1 | | Cobb, A | R | Hahn, J | Hendriks, L | Gray, J | R |
| 8/27/2021 | | @ | ChW | W | 7-5 | | Cobb, A | R | Holland, G | Hendriks, L | Freeland, K | L |
| 8/28/2021 | | | Hou | W | 8-0 | | Urias, J | L | Urias, J | Holland, G | Walker, T | R |
| 8/28/2021 | | @ | ChW | L | 3-4 | | Mills, A | R | Herget, J | | Eovaldi, N | R |
| 8/29/2021 | | | Hou | W | 4-1 | | Turnbull, S | R | Turnbull, S | Hendriks, L | Ponce de Leon, D | R |
| 8/29/2021 | | @ | ChW | L | 1-7 | | Lopez, J | R | Lopez, J | | Keller, M | R |
| 9/13/2021 | | | TB | W | 16-2 | | Cahill, T | R | Cahill, T | | Garrett, B | L |
| 9/13/2021 | | @ | NYY | W | 3-2 | | Cahill, T | R | Cahill, T | Hendriks, L | Bundy, D | R |
| 9/14/2021 | | | TB | W | 4-3 | | Turnbull, S | R | Turnbull, S | Hendriks, L | Canning, G | R |
| 9/14/2021 | | @ | NYY | L | 5-6 | | Lopez, J | R | Lopez, J | | Lynn, L | R |
| 9/15/2021 | | | TB | W | 7-1 | | Mills, A | R | Hahn, J | | Anderson, B | L |
| 9/15/2021 | | @ | NYY | L | 2-9 | | Mills, A | R | Mills, A | | May, D | R |
| 9/17/2021 | | | Tor | W | 12-7 | | Cobb, A | R | Cobb, A | Holland, G | Velasquez, V | R |
| 9/17/2021 | | @ | Bos | W | 7-4 | | Urias, J | L | Urias, J | Hendriks, L | Webb, L | R |
| 9/18/2021 | | | Tor | W | 14-11 | | Cahill, T | R | Hendriks, L | Hahn, J | Clarke, T | R |
| 9/18/2021 | | @ | Bos | W | 6-0 | | Curtiss, J | R | Holland, G | | Ynoa, H | R |
| 9/19/2021 | | | Tor | W | 7-2 | | Turnbull, S | R | Turnbull, S | | Newcomb, S | L |
| 9/19/2021 | | @ | Bos | W | 3-2 | | Cahill, T | R | Hunter, T | Nelson, N | Hudson, D | R |
| 9/20/2021 | | | Bos | L | 5-6 | | Mills, A | R | Mills, A | | Hudson, D | R |
| 9/20/2021 | | @ | Tor | W | 5-2 | | Lopez, J | R | Rodriguez, J | Nelson, N | Miley, W | L |
| 9/21/2021 | | | Bos | W | 1-0 | | Urias, J | L | Urias, J | Hendriks, L | Webb, L | R |
| 9/21/2021 | | @ | Tor | W | 5-4 | | Herget, J | R | Hunter, T | Holland, G | Roark, T | R |
| 9/22/2021 | | | Bos | L | 2-3 | | Cahill, T | R | Cahill, T | | Javier, C | R |
| 9/22/2021 | | @ | Tor | W | 12-8 | | Urias, J | L | Hendriks, L | | Clarke, T | R |
| 9/24/2021 | | | NYY | W | 7-0 | | Cobb, A | R | Cobb, A | | Lynn, L | R |
| 9/24/2021 | | @ | TB | W | 11-4 | | Curtiss, J | R | Holland, G | | Soroka, M | R |
| 9/25/2021 | | | NYY | L | 3-5 | | Turnbull, S | R | Turnbull, S | | Burnes, C | R |
| 9/25/2021 | | @ | TB | W | 5-3 | | Cahill, T | R | Cahill, T | Nelson, N | Wright, K | R |
| 9/26/2021 | | | NYY | W | 1-0 | | Urias, J | L | Urias, J | Hendriks, L | Bundy, D | R |
| 9/26/2021 | | @ | TB | W | 16-3 | | Lopez, J | R | Lopez, J | | Anderson, B | L |
| Other |
| | | | | | | | | Cumulative |
| Date | # | | Opp | | GWRBI | RF | RA | W | L | Pct | Last10 | Strk | Gm# |
| 9/28/2009 | | | Bos | L | | 4 | 9 | 116 | 47 | .712 | 7-3 | L1 | 163 |
| 4/15/2021 | | | NYY | W | Higashioka, K | 6 | 5 | 1 | 0 | 1.000 | 1-0 | W1 | 1 |
| 4/15/2021 | | @ | TB | W | Moran, C | 4 | 0 | 2 | 0 | 1.000 | 2-0 | W2 | 2 |
| 4/16/2021 | | | NYY | W | Higashioka, K | 2 | 0 | 3 | 0 | 1.000 | 3-0 | W3 | 3 |
| 4/16/2021 | | @ | TB | W | Walsh, J | 18 | 0 | 4 | 0 | 1.000 | 4-0 | W4 | 4 |
| 4/17/2021 | | | NYY | W | Walsh, J | 9 | 4 | 5 | 0 | 1.000 | 5-0 | W5 | 5 |
| 4/17/2021 | | @ | TB | W | Biggio, C | 12 | 7 | 6 | 0 | 1.000 | 6-0 | W6 | 6 |
| 4/19/2021 | | | Bos | L | | 1 | 2 | 6 | 1 | .857 | 6-1 | L1 | 7 |
| 4/19/2021 | | @ | Tor | L | | 2 | 3 | 6 | 2 | .750 | 6-2 | L2 | 8 |
| 4/20/2021 | | | Bos | W | Higashioka, K | 2 | 0 | 7 | 2 | .778 | 7-2 | W1 | 9 |
| 4/20/2021 | | @ | Tor | W | Biggio, C | 14 | 4 | 8 | 2 | .800 | 8-2 | W2 | 10 |
| 4/21/2021 | | | Bos | L | | 3 | 7 | 8 | 3 | .727 | 7-3 | L1 | 11 |
| 4/21/2021 | | @ | Tor | W | Ward, T | 7 | 0 | 9 | 3 | .750 | 7-3 | W1 | 12 |
| 4/22/2021 | | | Tor | L | | 1 | 4 | 9 | 4 | .692 | 6-4 | L1 | 13 |
| 4/22/2021 | | @ | Bos | L | | 2 | 5 | 9 | 5 | .643 | 5-5 | L2 | 14 |
| 4/23/2021 | | | Tor | L | | 10 | 12 | 9 | 6 | .600 | 4-6 | L3 | 15 |
| 4/23/2021 | | @ | Bos | W | Hernandez, T | 7 | 5 | 10 | 6 | .625 | 4-6 | W1 | 16 |
| 4/24/2021 | | | Tor | W | Moran, C | 4 | 1 | 11 | 6 | .647 | 5-5 | W2 | 17 |
| 4/24/2021 | | @ | Bos | W | Walsh, J | 6 | 1 | 12 | 6 | .667 | 6-4 | W3 | 18 |
| 4/26/2021 | | | TB | W | Moran, C | 6 | 4 | 13 | 6 | .684 | 6-4 | W4 | 19 |
| 4/26/2021 | | @ | NYY | L | | 1 | 2 | 13 | 7 | .650 | 5-5 | L1 | 20 |
| 4/27/2021 | | | TB | W | Ward, T | 18 | 9 | 14 | 7 | .667 | 6-4 | W1 | 21 |
| 4/27/2021 | | @ | NYY | W | Arozarena, R | 5 | 2 | 15 | 7 | .682 | 6-4 | W2 | 22 |
| 4/28/2021 | | | TB | W | Arozarena, R | 8 | 4 | 16 | 7 | .696 | 7-3 | W3 | 23 |
| 4/28/2021 | | @ | NYY | W | Walsh, J | 2 | 0 | 17 | 7 | .708 | 8-2 | W4 | 24 |
| 5/13/2021 | | @ | Cin | W | Hernandez, T | 9 | 1 | 18 | 7 | .720 | 9-1 | W5 | 25 |
| 5/13/2021 | | | LAD | W | Hernandez, T | 5 | 3 | 19 | 7 | .731 | 9-1 | W6 | 26 |
| 5/14/2021 | | @ | Cin | L | | 3 | 10 | 19 | 8 | .704 | 8-2 | L1 | 27 |
| 5/14/2021 | | | LAD | L | | 3 | 6 | 19 | 9 | .679 | 7-3 | L2 | 28 |
| 5/15/2021 | | @ | Cin | W | Moran, C | 7 | 6 | 20 | 9 | .690 | 7-3 | W1 | 29 |
| 5/15/2021 | | | LAD | L | | 3 | 4 | 20 | 10 | .667 | 7-3 | L1 | 30 |
| 5/17/2021 | | | Ari | W | Biggio, C | 7 | 1 | 21 | 10 | .677 | 7-3 | W1 | 31 |
| 5/17/2021 | | @ | Mil | L | | 3 | 9 | 21 | 11 | .656 | 6-4 | L1 | 32 |
| 5/18/2021 | | | Ari | L | | 0 | 1 | 21 | 12 | .636 | 5-5 | L2 | 33 |
| 5/18/2021 | | @ | Mil | W | Ward, T | 3 | 2 | 22 | 12 | .647 | 5-5 | W1 | 34 |
| 5/19/2021 | | | Ari | L | | 1 | 4 | 22 | 13 | .629 | 4-6 | L1 | 35 |
| 5/19/2021 | | @ | Mil | L | | 1 | 4 | 22 | 14 | .611 | 3-7 | L2 | 36 |
| 5/21/2021 | | @ | ChC | W | Stanton, G | 12 | 8 | 23 | 14 | .622 | 4-6 | W1 | 37 |
| 5/21/2021 | | | Col | L | | 1 | 8 | 23 | 15 | .605 | 4-6 | L1 | 38 |
| 5/22/2021 | | @ | ChC | W | Crawford, J | 1 | 0 | 24 | 15 | .615 | 4-6 | W1 | 39 |
| 5/22/2021 | | | Col | W | Avila, A | 6 | 2 | 25 | 15 | .625 | 5-5 | W2 | 40 |
| 5/23/2021 | | @ | ChC | L | | 2 | 5 | 25 | 16 | .610 | 4-6 | L1 | 41 |
| 5/23/2021 | | | Col | L | | 3 | 8 | 25 | 17 | .595 | 4-6 | L2 | 42 |
| 5/24/2021 | | @ | StL | W | Hayes, K | 8 | 2 | 26 | 17 | .605 | 5-5 | W1 | 43 |
| 5/24/2021 | | | SF | W | Arozarena, R | 5 | 0 | 27 | 17 | .614 | 5-5 | W2 | 44 |
| 5/25/2021 | | @ | StL | W | Longoria, E | 8 | 5 | 28 | 17 | .622 | 6-4 | W3 | 45 |
| 5/25/2021 | | | SF | W | Longoria, E | 5 | 2 | 29 | 17 | .630 | 7-3 | W4 | 46 |
| 5/26/2021 | | @ | StL | W | Hernandez, T | 5 | 1 | 30 | 17 | .638 | 7-3 | W5 | 47 |
| 5/26/2021 | | | SF | W | Dickerson, C | 4 | 3 | 31 | 17 | .646 | 8-2 | W6 | 48 |
| 5/28/2021 | | @ | Pit | W | Arozarena, R | 6 | 5 | 32 | 17 | .653 | 8-2 | W7 | 49 |
| 5/28/2021 | | | SD | W | Stanton, G | 3 | 2 | 33 | 17 | .660 | 8-2 | W8 | 50 |
| 5/29/2021 | | @ | Pit | W | | 10 | 4 | 34 | 17 | .667 | 9-1 | W9 | 51 |
| 5/29/2021 | | | SD | L | | 2 | 4 | 34 | 18 | .654 | 9-1 | L1 | 52 |
| 5/30/2021 | | @ | Pit | W | Kemp, T | 10 | 4 | 35 | 18 | .660 | 9-1 | W1 | 53 |
| 5/30/2021 | | | SD | L | | 0 | 3 | 35 | 19 | .648 | 8-2 | L1 | 54 |
| 6/14/2021 | | @ | Hou | W | Hernandez, T | 5 | 2 | 36 | 19 | .655 | 8-2 | W1 | 55 |
| 6/14/2021 | | | Min | W | | 8 | 4 | 37 | 19 | .661 | 8-2 | W2 | 56 |
| 6/15/2021 | | @ | Hou | W | Biggio, C | 5 | 2 | 38 | 19 | .667 | 8-2 | W3 | 57 |
| 6/15/2021 | | | Min | L | | 3 | 7 | 38 | 20 | .655 | 7-3 | L1 | 58 |
| 6/16/2021 | | @ | Hou | L | | 2 | 3 | 38 | 21 | .644 | 6-4 | L2 | 59 |
| 6/16/2021 | | | Min | W | Moran, C | 8 | 6 | 39 | 21 | .650 | 6-4 | W1 | 60 |
| 6/17/2021 | | | ChW | L | | 1 | 5 | 39 | 22 | .639 | 5-5 | L1 | 61 |
| 6/17/2021 | | @ | Oak | W | Crawford, J | 3 | 0 | 40 | 22 | .645 | 6-4 | W1 | 62 |
| 6/18/2021 | | | ChW | W | Moran, C | 2 | 1 | 41 | 22 | .651 | 6-4 | W2 | 63 |
| 6/18/2021 | | @ | Oak | W | Kemp, T | 3 | 0 | 42 | 22 | .656 | 7-3 | W3 | 64 |
| 6/19/2021 | | | ChW | W | Stanton, G | 13 | 0 | 43 | 22 | .662 | 7-3 | W4 | 65 |
| 6/19/2021 | | @ | Oak | W | Hernandez, T | 9 | 5 | 44 | 22 | .667 | 7-3 | W5 | 66 |
| 6/21/2021 | | | Det | L | | 3 | 4 | 44 | 23 | .657 | 6-4 | L1 | 67 |
| 6/21/2021 | | @ | LAA | L | | 2 | 3 | 44 | 24 | .647 | 6-4 | L2 | 68 |
| 6/22/2021 | | | Det | L | | 3 | 7 | 44 | 25 | .638 | 6-4 | L3 | 69 |
| 6/22/2021 | | @ | LAA | W | Longoria, E | 10 | 0 | 45 | 25 | .643 | 6-4 | W1 | 70 |
| 6/23/2021 | | | Det | L | | 3 | 7 | 45 | 26 | .634 | 6-4 | L1 | 71 |
| 6/23/2021 | | @ | LAA | W | | 7 | 4 | 46 | 26 | .639 | 6-4 | W1 | 72 |
| 6/24/2021 | | | Cle | W | Avila, A | 5 | 2 | 47 | 26 | .644 | 6-4 | W2 | 73 |
| 6/24/2021 | | @ | Tex | W | Biggio, C | 3 | 0 | 48 | 26 | .649 | 6-4 | W3 | 74 |
| 6/25/2021 | | | Cle | W | Kemp, T | 4 | 3 | 49 | 26 | .653 | 6-4 | W4 | 75 |
| 6/25/2021 | | @ | Tex | W | Stanton, G | 8 | 2 | 50 | 26 | .658 | 6-4 | W5 | 76 |
| 6/26/2021 | | | Cle | W | Hernandez, T | 6 | 3 | 51 | 26 | .662 | 7-3 | W6 | 77 |
| 6/26/2021 | | @ | Tex | W | Biggio, C | 8 | 5 | 52 | 26 | .667 | 8-2 | W7 | 78 |
| 6/28/2021 | | | KC | W | Crawford, J | 3 | 2 | 53 | 26 | .671 | 9-1 | W8 | 79 |
| 6/28/2021 | | @ | Sea | W | Arozarena, R | 10 | 5 | 54 | 26 | .675 | 9-1 | W9 | 80 |
| 6/29/2021 | | | KC | W | Ward, T | 5 | 3 | 55 | 26 | .679 | 10-0 | W10 | 81 |
| 6/29/2021 | | @ | Sea | L | | 3 | 4 | 55 | 27 | .671 | 9-1 | L1 | 82 |
| 6/30/2021 | | | KC | W | Arozarena, R | 18 | 2 | 56 | 27 | .675 | 9-1 | W1 | 83 |
| 6/30/2021 | | @ | Sea | W | | 8 | 2 | 57 | 27 | .679 | 9-1 | W2 | 84 |
| 7/15/2021 | | | Bos | L | | 0 | 12 | 57 | 28 | .671 | 8-2 | L1 | 85 |
| 7/15/2021 | | @ | Tor | W | Walsh, J | 9 | 3 | 58 | 28 | .674 | 8-2 | W1 | 86 |
| 7/16/2021 | | | Bos | L | | 5 | 10 | 58 | 29 | .667 | 7-3 | L1 | 87 |
| 7/16/2021 | | @ | Tor | W | Walsh, J | 8 | 1 | 59 | 29 | .670 | 7-3 | W1 | 88 |
| 7/17/2021 | | | Bos | W | Higashioka, K | 6 | 0 | 60 | 29 | .674 | 7-3 | W2 | 89 |
| 7/17/2021 | | @ | Tor | W | Kemp, T | 11 | 3 | 61 | 29 | .678 | 7-3 | W3 | 90 |
| 7/19/2021 | | | TB | W | Arozarena, R | 6 | 5 | 62 | 29 | .681 | 7-3 | W4 | 91 |
| 7/19/2021 | | @ | NYY | L | | 5 | 12 | 62 | 30 | .674 | 7-3 | L1 | 92 |
| 7/20/2021 | | | TB | L | | 2 | 7 | 62 | 31 | .667 | 6-4 | L2 | 93 |
| 7/20/2021 | | @ | NYY | L | | 2 | 4 | 62 | 32 | .660 | 5-5 | L3 | 94 |
| 7/21/2021 | | | TB | W | Walsh, J | 16 | 1 | 63 | 32 | .663 | 6-4 | W1 | 95 |
| 7/21/2021 | | @ | NYY | W | Walsh, J | 5 | 4 | 64 | 32 | .667 | 6-4 | W2 | 96 |
| 7/22/2021 | | | NYY | W | Higashioka, K | 7 | 2 | 65 | 32 | .670 | 7-3 | W3 | 97 |
| 7/22/2021 | | @ | TB | W | Longoria, E | 8 | 0 | 66 | 32 | .673 | 7-3 | W4 | 98 |
| 7/23/2021 | | | NYY | L | | 3 | 5 | 66 | 33 | .667 | 6-4 | L1 | 99 |
| 7/23/2021 | | @ | TB | W | Avila, A | 4 | 3 | 67 | 33 | .670 | 6-4 | W1 | 100 |
| 7/24/2021 | | | NYY | W | Moran, C | 2 | 0 | 68 | 33 | .673 | 6-4 | W2 | 101 |
| 7/24/2021 | | @ | TB | W | Walsh, J | 4 | 3 | 69 | 33 | .676 | 7-3 | W3 | 102 |
| 7/26/2021 | | | Tor | W | Hernandez, T | 10 | 3 | 70 | 33 | .680 | 8-2 | W4 | 103 |
| 7/26/2021 | | @ | Bos | L | | 3 | 6 | 70 | 34 | .673 | 8-2 | L1 | 104 |
| 7/27/2021 | | | Tor | W | Crawford, J | 2 | 1 | 71 | 34 | .676 | 8-2 | W1 | 105 |
| 7/27/2021 | | @ | Bos | W | Hernandez, T | 4 | 3 | 72 | 34 | .679 | 8-2 | W2 | 106 |
| 7/28/2021 | | | Tor | W | Biggio, C | 7 | 1 | 73 | 34 | .682 | 8-2 | W3 | 107 |
| 7/28/2021 | | @ | Bos | W | Hayes, K | 3 | 1 | 74 | 34 | .685 | 8-2 | W4 | 108 |
| 8/13/2021 | | | Sea | W | Ward, T | 3 | 2 | 75 | 34 | .688 | 9-1 | W5 | 109 |
| 8/13/2021 | | @ | Min | L | | 4 | 15 | 75 | 35 | .682 | 8-2 | L1 | 110 |
| 8/14/2021 | | | Sea | L | | 4 | 7 | 75 | 36 | .676 | 7-3 | L2 | 111 |
| 8/14/2021 | | @ | Min | W | Moran, C | 8 | 2 | 76 | 36 | .679 | 7-3 | W1 | 112 |
| 8/15/2021 | | | Sea | W | Avila, A | 3 | 0 | 77 | 36 | .681 | 7-3 | W2 | 113 |
| 8/15/2021 | | @ | Min | W | Moran, C | 9 | 4 | 78 | 36 | .684 | 8-2 | W3 | 114 |
| 8/16/2021 | | | Oak | W | Moran, C | 4 | 1 | 79 | 36 | .687 | 8-2 | W4 | 115 |
| 8/16/2021 | | @ | Cle | W | Walsh, J | 14 | 3 | 80 | 36 | .690 | 8-2 | W5 | 116 |
| 8/17/2021 | | | Oak | L | | 0 | 1 | 80 | 37 | .684 | 7-3 | L1 | 117 |
| 8/17/2021 | | @ | Cle | W | Hernandez, T | 3 | 1 | 81 | 37 | .686 | 7-3 | W1 | 118 |
| 8/18/2021 | | | Oak | W | Hayes, K | 5 | 4 | 82 | 37 | .689 | 7-3 | W2 | 119 |
| 8/18/2021 | | @ | Cle | W | Arozarena, R | 7 | 4 | 83 | 37 | .692 | 8-2 | W3 | 120 |
| 8/20/2021 | | | LAA | W | Hayes, K | 8 | 6 | 84 | 37 | .694 | 9-1 | W4 | 121 |
| 8/20/2021 | | @ | Det | L | | 2 | 4 | 84 | 38 | .689 | 8-2 | L1 | 122 |
| 8/21/2021 | | | LAA | L | | 2 | 6 | 84 | 39 | .683 | 7-3 | L2 | 123 |
| 8/21/2021 | | @ | Det | W | Kirk, A | 7 | 2 | 85 | 39 | .685 | 7-3 | W1 | 124 |
| 8/22/2021 | | | LAA | W | Walsh, J | 4 | 3 | 86 | 39 | .688 | 7-3 | W2 | 125 |
| 8/22/2021 | | @ | Det | W | Arozarena, R | 17 | 6 | 87 | 39 | .690 | 7-3 | W3 | 126 |
| 8/23/2021 | | | Tex | W | Hernandez, T | 7 | 3 | 88 | 39 | .693 | 8-2 | W4 | 127 |
| 8/23/2021 | | @ | KC | W | Biggio, C | 12 | 2 | 89 | 39 | .695 | 8-2 | W5 | 128 |
| 8/24/2021 | | | Tex | W | Walsh, J | 15 | 2 | 90 | 39 | .698 | 8-2 | W6 | 129 |
| 8/24/2021 | | @ | KC | W | Hayes, K | 8 | 6 | 91 | 39 | .700 | 8-2 | W7 | 130 |
| 8/25/2021 | | | Tex | W | Longoria, E | 7 | 1 | 92 | 39 | .702 | 8-2 | W8 | 131 |
| 8/25/2021 | | @ | KC | W | Arozarena, R | 4 | 3 | 93 | 39 | .705 | 9-1 | W9 | 132 |
| 8/27/2021 | | | Hou | W | Crawford, J | 4 | 1 | 94 | 39 | .707 | 10-0 | W10 | 133 |
| 8/27/2021 | | @ | ChW | W | Hayes, K | 7 | 5 | 95 | 39 | .709 | 10-0 | W11 | 134 |
| 8/28/2021 | | | Hou | W | Walsh, J | 8 | 0 | 96 | 39 | .711 | 10-0 | W12 | 135 |
| 8/28/2021 | | @ | ChW | L | | 3 | 4 | 96 | 40 | .706 | 9-1 | L1 | 136 |
| 8/29/2021 | | | Hou | W | Ward, T | 4 | 1 | 97 | 40 | .708 | 9-1 | W1 | 137 |
| 8/29/2021 | | @ | ChW | L | | 1 | 7 | 97 | 41 | .703 | 8-2 | L1 | 138 |
| 9/13/2021 | | | TB | W | Arozarena, R | 16 | 2 | 98 | 41 | .705 | 8-2 | W1 | 139 |
| 9/13/2021 | | @ | NYY | W | Walsh, J | 3 | 2 | 99 | 41 | .707 | 8-2 | W2 | 140 |
| 9/14/2021 | | | TB | W | Walsh, J | 4 | 3 | 100 | 41 | .709 | 8-2 | W3 | 141 |
| 9/14/2021 | | @ | NYY | L | | 5 | 6 | 100 | 42 | .704 | 7-3 | L1 | 142 |
| 9/15/2021 | | | TB | W | Hayes, K | 7 | 1 | 101 | 42 | .706 | 7-3 | W1 | 143 |
| 9/15/2021 | | @ | NYY | L | | 2 | 9 | 101 | 43 | .701 | 6-4 | L1 | 144 |
| 9/17/2021 | | | Tor | W | Higashioka, K | 12 | 7 | 102 | 43 | .703 | 6-4 | W1 | 145 |
| 9/17/2021 | | @ | Bos | W | Hayes, K | 7 | 4 | 103 | 43 | .705 | 7-3 | W2 | 146 |
| 9/18/2021 | | | Tor | W | Biggio, C | 14 | 11 | 104 | 43 | .707 | 7-3 | W3 | 147 |
| 9/18/2021 | | @ | Bos | W | Higashioka, K | 6 | 0 | 105 | 43 | .709 | 8-2 | W4 | 148 |
| 9/19/2021 | | | Tor | W | Hayes, K | 7 | 2 | 106 | 43 | .711 | 8-2 | W5 | 149 |
| 9/19/2021 | | @ | Bos | W | Higashioka, K | 3 | 2 | 107 | 43 | .713 | 8-2 | W6 | 150 |
| 9/20/2021 | | | Bos | L | | 5 | 6 | 107 | 44 | .709 | 7-3 | L1 | 151 |
| 9/20/2021 | | @ | Tor | W | Crawford, J | 5 | 2 | 108 | 44 | .711 | 8-2 | W1 | 152 |
| 9/21/2021 | | | Bos | W | Higashioka, K | 1 | 0 | 109 | 44 | .712 | 8-2 | W2 | 153 |
| 9/21/2021 | | @ | Tor | W | Hayes, K | 5 | 4 | 110 | 44 | .714 | 9-1 | W3 | 154 |
| 9/22/2021 | | | Bos | L | | 2 | 3 | 110 | 45 | .710 | 8-2 | L1 | 155 |
| 9/22/2021 | | @ | Tor | W | | 12 | 8 | 111 | 45 | .712 | 8-2 | W1 | 156 |
| 9/24/2021 | | | NYY | W | Kemp, T | 7 | 0 | 112 | 45 | .713 | 8-2 | W2 | 157 |
| 9/24/2021 | | @ | TB | W | Walsh, J | 11 | 4 | 113 | 45 | .715 | 8-2 | W3 | 158 |
| 9/25/2021 | | | NYY | L | | 3 | 5 | 113 | 46 | .711 | 7-3 | L1 | 159 |
| 9/25/2021 | | @ | TB | W | Dickerson, C | 5 | 3 | 114 | 46 | .712 | 7-3 | W1 | 160 |
| 9/26/2021 | | | NYY | W | Arozarena, R | 1 | 0 | 115 | 46 | .714 | 8-2 | W2 | 161 |
| 9/26/2021 | | @ | TB | W | Arozarena, R | 16 | 3 | 116 | 46 | .716 | 8-2 | W3 | 162 |