Team game results - 2021 Pittsburgh Pirates
Regular season
| Primary |
| Date | # | | Opp | | Score | Inn | Starter | T | W/L | Save | Versus | T |
| 4/15/2021 | | @ | Cin | L | 1-4 | | Davies, Z | R | Davies, Z | | Woodruff, B | R |
| 4/15/2021 | | | StL | W | 4-1 | | Davies, Z | R | Davies, Z | Tate, D | Carrasco, C | R |
| 4/16/2021 | | @ | Cin | L | 5-13 | | Mize, C | R | Mize, C | | Berrios, J | R |
| 4/16/2021 | | | StL | W | 4-2 | | McCullers, L | R | McCullers, L | Brogdon, C | Heaney, A | L |
| 4/17/2021 | | @ | Cin | L | 6-7 | | Senzatela, A | R | Leclerc, J | | Kikuchi, Y | L |
| 4/17/2021 | | | StL | W | 3-0 | | Senzatela, A | R | Senzatela, A | Tate, D | Ray, R | L |
| 4/19/2021 | | | ChC | L | 4-13 | | Samardzija, J | R | Samardzija, J | | Keuchel, D | L |
| 4/19/2021 | | @ | Mil | L | 2-5 | | Samardzija, J | R | Samardzija, J | | Gonsolin, T | R |
| 4/20/2021 | | | ChC | W | 5-3 | | Davies, Z | R | Davies, Z | Brogdon, C | Montas, F | R |
| 4/20/2021 | | @ | Mil | L | 3-5 | | Davies, Z | R | Raley, B | | Richards, G | R |
| 4/21/2021 | | | ChC | L | 3-4 | | McCullers, L | R | McCullers, L | | Happ, J | L |
| 4/21/2021 | | @ | Mil | L | 4-5 | | Mize, C | R | Leclerc, J | | Kershaw, C | L |
| 4/22/2021 | | @ | ChC | W | 3-1 | | Senzatela, A | R | Senzatela, A | | Happ, J | L |
| 4/22/2021 | | | Mil | W | 7-4 | | Senzatela, A | R | Senzatela, A | Schreiber, J | Gonsolin, T | R |
| 4/23/2021 | | @ | ChC | L | 3-4 | | McCullers, L | R | McCullers, L | | Alzolay, A | R |
| 4/23/2021 | | | Mil | W | 1-0 | | Montgomery, J | L | Montgomery, J | Brogdon, C | Kershaw, C | L |
| 4/24/2021 | | @ | ChC | L | 3-9 | | Samardzija, J | R | Samardzija, J | | Greinke, Z | R |
| 4/24/2021 | | | Mil | L | 2-3 | | Davies, Z | R | Brogdon, C | | Smith, C | L |
| 4/26/2021 | | | Cin | L | 3-9 | | Samardzija, J | R | Samardzija, J | | Lyles, J | R |
| 4/26/2021 | | @ | StL | L | 5-6 | | Davies, Z | R | Leclerc, J | | Harvey, M | R |
| 4/27/2021 | | | Cin | W | 5-4 | | McCullers, L | R | Tate, D | Brogdon, C | Berrios, J | R |
| 4/27/2021 | | @ | StL | L | 3-4 | 10 | Mize, C | R | Phelps, D | | Heaney, A | L |
| 4/28/2021 | | | Cin | L | 2-4 | 10 | Montgomery, J | L | Brogdon, C | | Plesac, Z | R |
| 4/28/2021 | | @ | StL | W | 8-3 | | McCullers, L | R | McCullers, L | | Paxton, J | L |
| 5/13/2021 | | | Bos | L | 1-12 | | Senzatela, A | R | Senzatela, A | | Merryweather, J | R |
| 5/13/2021 | | @ | Sea | L | 3-10 | | Davies, Z | R | Davies, Z | | Skubal, T | L |
| 5/14/2021 | | | Bos | L | 1-2 | | Montgomery, J | L | Helsley, R | | Plutko, A | R |
| 5/14/2021 | | @ | Sea | L | 6-11 | | Montgomery, J | L | Montgomery, J | | Minor, M | L |
| 5/15/2021 | | | Bos | L | 2-8 | | Davies, Z | R | Davies, Z | | Hudson, D | R |
| 5/15/2021 | | @ | Sea | L | 4-12 | | Senzatela, A | R | Senzatela, A | | Glasnow, T | R |
| 5/17/2021 | | @ | Hou | L | 5-6 | | McCullers, L | R | Leclerc, J | | Smyly, D | L |
| 5/17/2021 | | | NYY | L | 5-7 | | Sandoval, P | L | Tate, D | | May, D | R |
| 5/18/2021 | | @ | Hou | L | 1-7 | | Davies, Z | R | Davies, Z | | Hill, R | L |
| 5/18/2021 | | | NYY | L | 0-5 | | Senzatela, A | R | Senzatela, A | | Duffy, D | L |
| 5/19/2021 | | @ | Hou | L | 1-3 | | Sandoval, P | L | Sandoval, P | | Gray, J | R |
| 5/19/2021 | | | NYY | L | 5-7 | 12 | McCullers, L | R | Osich, J | | Lynn, L | R |
| 5/21/2021 | | | TB | W | 15-1 | | Montgomery, J | L | Montgomery, J | | Smeltzer, D | L |
| 5/21/2021 | | @ | Oak | L | 0-11 | | Montgomery, J | L | Montgomery, J | | Scherzer, M | R |
| 5/22/2021 | | | TB | L | 2-4 | | Davies, Z | R | Davies, Z | | Anderson, B | L |
| 5/22/2021 | | @ | Oak | L | 4-9 | | Senzatela, A | R | Senzatela, A | | Cueto, J | R |
| 5/23/2021 | | | TB | W | 1-0 | | Senzatela, A | R | Senzatela, A | | Wright, K | R |
| 5/23/2021 | | @ | Oak | L | 5-7 | | Davies, Z | R | Davies, Z | | Fried, M | L |
| 5/24/2021 | | | Tor | W | 11-6 | | Sandoval, P | L | Sandoval, P | Helsley, R | Velasquez, V | R |
| 5/24/2021 | | @ | LAA | L | 6-14 | | McCullers, L | R | McCullers, L | | Boyd, M | L |
| 5/25/2021 | | | Tor | L | 4-12 | 10 | McCullers, L | R | Raley, B | | Roark, T | R |
| 5/25/2021 | | @ | LAA | L | 1-4 | | Sandoval, P | L | Sandoval, P | | Gomber, A | L |
| 5/26/2021 | | | Tor | W | 12-0 | | Montgomery, J | L | Montgomery, J | | Lorenzen, M | R |
| 5/26/2021 | | @ | LAA | L | 3-5 | | Montgomery, J | L | Montgomery, J | | Pineda, M | R |
| 5/28/2021 | | | Bal | L | 5-6 | | Davies, Z | R | Davies, Z | | Mills, A | R |
| 5/28/2021 | | @ | Tex | W | 6-4 | 10 | Senzatela, A | R | Raley, B | Brogdon, C | Fulmer, M | R |
| 5/29/2021 | | | Bal | L | 4-10 | 10 | Senzatela, A | R | Tate, D | | Urias, J | L |
| 5/29/2021 | | @ | Tex | W | 6-3 | | Davies, Z | R | Davies, Z | | Stripling, R | R |
| 5/30/2021 | | | Bal | L | 4-10 | | McCullers, L | R | McCullers, L | | Cahill, T | R |
| 5/30/2021 | | @ | Tex | W | 4-1 | | Sandoval, P | L | Sandoval, P | Brogdon, C | Teheran, J | R |
| 6/14/2021 | | @ | Phi | L | 0-3 | | Davies, Z | R | Davies, Z | | Castillo, L | R |
| 6/14/2021 | | | SD | L | 1-2 | 11 | Montgomery, J | L | Raley, B | | Alcantara, S | R |
| 6/15/2021 | | @ | Phi | L | 1-2 | | McCullers, L | R | Raley, B | | Sheffield, J | L |
| 6/15/2021 | | | SD | W | 5-3 | | Senzatela, A | R | Senzatela, A | Osich, J | Gausman, K | R |
| 6/16/2021 | | @ | Phi | L | 5-6 | | Senzatela, A | R | Senzatela, A | | Manaea, S | L |
| 6/16/2021 | | | SD | W | 6-0 | | McCullers, L | R | McCullers, L | | Perez, M | L |
| 6/17/2021 | | @ | Atl | L | 2-5 | | Mize, C | R | Mize, C | | Barria, J | R |
| 6/17/2021 | | | LAD | W | 3-2 | | Samardzija, J | R | Garcia, L | | Lopez, P | R |
| 6/18/2021 | | @ | Atl | L | 0-18 | | Samardzija, J | R | Samardzija, J | | Milone, T | L |
| 6/18/2021 | | | LAD | W | 5-3 | | Sandoval, P | L | Tate, D | Raley, B | Snell, B | L |
| 6/19/2021 | | @ | Atl | W | 3-2 | | Davies, Z | R | Davies, Z | Brogdon, C | Corbin, P | L |
| 6/19/2021 | | | LAD | W | 10-5 | | Montgomery, J | L | Montgomery, J | | deGrom, J | R |
| 6/21/2021 | | @ | NYM | W | 4-2 | | McCullers, L | R | McCullers, L | Brogdon, C | Luzardo, J | L |
| 6/21/2021 | | | Ari | W | 4-0 | | McCullers, L | R | McCullers, L | Raley, B | Ryu, H | L |
| 6/22/2021 | | @ | NYM | W | 5-4 | | Senzatela, A | R | Senzatela, A | Brogdon, C | Dunning, D | R |
| 6/22/2021 | | | Ari | W | 6-2 | | Senzatela, A | R | Senzatela, A | | Gray, S | R |
| 6/23/2021 | | @ | NYM | L | 6-7 | 12 | Samardzija, J | R | Jackson, L | | Howard, S | R |
| 6/23/2021 | | | Ari | W | 4-1 | | Montgomery, J | L | Montgomery, J | Tate, D | Maeda, K | R |
| 6/24/2021 | | @ | Was | L | 5-10 | | Mize, C | R | Phelps, D | | Kelly, M | R |
| 6/24/2021 | | | Col | L | 3-8 | | Samardzija, J | R | Samardzija, J | | Godley, Z | R |
| 6/25/2021 | | @ | Was | L | 2-6 | | Davies, Z | R | Davies, Z | | Hendricks, K | R |
| 6/25/2021 | | | Col | L | 3-4 | 12 | Montgomery, J | L | Garcia, L | | Cole, G | R |
| 6/26/2021 | | @ | Was | L | 6-12 | | McCullers, L | R | McCullers, L | | Bassitt, C | R |
| 6/26/2021 | | | Col | L | 1-10 | | Senzatela, A | R | Senzatela, A | | Bieber, S | R |
| 6/28/2021 | | | SF | W | 2-1 | 10 | McCullers, L | R | Garcia, L | | Junis, J | R |
| 6/28/2021 | | @ | Mia | L | 1-2 | | Senzatela, A | R | Raley, B | | Eflin, Z | R |
| 6/29/2021 | | | SF | W | 9-1 | | Sandoval, P | L | Jackson, L | | Hernandez, C | R |
| 6/29/2021 | | @ | Mia | L | 1-5 | | Samardzija, J | R | Samardzija, J | | Tomlin, J | R |
| 6/30/2021 | | | SF | W | 4-0 | | Montgomery, J | L | Montgomery, J | Tate, D | Bailey, H | R |
| 6/30/2021 | | @ | Mia | L | 1-2 | | Davies, Z | R | Davies, Z | | Fleming, J | L |
| 7/15/2021 | | | ChC | L | 7-12 | | Davies, Z | R | Davies, Z | | Montas, F | R |
| 7/15/2021 | | @ | Mil | L | 4-9 | | Davies, Z | R | Davies, Z | | Richards, G | R |
| 7/16/2021 | | | ChC | L | 2-7 | | McCullers, L | R | McCullers, L | | Keuchel, D | L |
| 7/16/2021 | | @ | Mil | L | 0-4 | | McCullers, L | R | McCullers, L | | Kershaw, C | L |
| 7/17/2021 | | | ChC | W | 5-3 | | Senzatela, A | R | Senzatela, A | Tate, D | King, M | R |
| 7/17/2021 | | @ | Mil | W | 9-3 | | Senzatela, A | R | Senzatela, A | | Morton, C | R |
| 7/19/2021 | | | Cin | W | 8-0 | | Senzatela, A | R | Senzatela, A | | Lyles, J | R |
| 7/19/2021 | | @ | StL | L | 4-5 | 10 | Garcia, L | R | Brogdon, C | | Harvey, M | R |
| 7/20/2021 | | | Cin | L | 3-8 | 11 | McCullers, L | R | Tate, D | | Woodruff, B | R |
| 7/20/2021 | | @ | StL | W | 3-2 | | Davies, Z | R | Davies, Z | Brogdon, C | Carrasco, C | R |
| 7/21/2021 | | | Cin | W | 7-5 | | Davies, Z | R | Davies, Z | Alvarado, J | Berrios, J | R |
| 7/21/2021 | | @ | StL | L | 0-3 | | McCullers, L | R | McCullers, L | | Heaney, A | L |
| 7/22/2021 | | @ | Cin | L | 1-5 | | Senzatela, A | R | Senzatela, A | | Kikuchi, Y | L |
| 7/22/2021 | | | StL | W | 8-6 | | Mize, C | R | Osich, J | Tate, D | Carrasco, C | R |
| 7/23/2021 | | @ | Cin | W | 12-5 | | Mize, C | R | Mize, C | | Plesac, Z | R |
| 7/23/2021 | | | StL | L | 4-6 | | Garcia, L | R | Garcia, L | | Oviedo, J | R |
| 7/24/2021 | | @ | Cin | L | 2-7 | | Davies, Z | R | Davies, Z | | Woodruff, B | R |
| 7/24/2021 | | | StL | W | 5-2 | | McCullers, L | R | McCullers, L | Jackson, L | Newsome, L | R |
| 7/26/2021 | | @ | ChC | L | 1-7 | | Garcia, L | R | Garcia, L | | Happ, J | L |
| 7/26/2021 | | | Mil | W | 10-9 | 12 | Senzatela, A | R | Helsley, R | | Morton, C | R |
| 7/27/2021 | | @ | ChC | L | 6-12 | | McCullers, L | R | McCullers, L | | Alzolay, A | R |
| 7/27/2021 | | | Mil | L | 1-10 | | Davies, Z | R | Davies, Z | | Brault, S | L |
| 7/28/2021 | | @ | ChC | L | 4-7 | | Mize, C | R | Mize, C | | Montas, F | R |
| 7/28/2021 | | | Mil | L | 8-10 | | Garcia, L | R | Garcia, L | | Richards, G | R |
| 8/13/2021 | | | NYM | W | 8-7 | | McCullers, L | R | Osich, J | | Erlin, R | L |
| 8/13/2021 | | @ | Ari | L | 3-5 | | Montgomery, J | L | Montgomery, J | | Maeda, K | R |
| 8/14/2021 | | | NYM | W | 10-0 | | Davies, Z | R | Davies, Z | | Mengden, D | R |
| 8/14/2021 | | @ | Ari | W | 3-1 | | Sandoval, P | L | Sandoval, P | Raley, B | Gray, S | R |
| 8/15/2021 | | | NYM | W | 4-3 | | Mize, C | R | Mize, C | Tate, D | Gonzalez, G | L |
| 8/15/2021 | | @ | Ari | L | 4-7 | | Mize, C | R | Mize, C | | Ryu, H | L |
| 8/16/2021 | | | Mia | L | 1-8 | | Mize, C | R | Mize, C | | Tomlin, J | R |
| 8/16/2021 | | @ | Col | L | 7-13 | | Senzatela, A | R | Senzatela, A | | Mejia, H | R |
| 8/17/2021 | | | Mia | W | 3-2 | | Montgomery, J | L | Tate, D | | Brubaker, J | R |
| 8/17/2021 | | @ | Col | L | 4-5 | | McCullers, L | R | McCullers, L | | Bieber, S | R |
| 8/18/2021 | | | Mia | L | 0-1 | 14 | Davies, Z | R | Osich, J | | Valdez, F | L |
| 8/18/2021 | | @ | Col | L | 5-9 | | Montgomery, J | L | Schreiber, J | | Cole, G | R |
| 8/20/2021 | | @ | LAD | L | 1-5 | | Sandoval, P | L | Sandoval, P | | Lopez, P | R |
| 8/20/2021 | | | Was | L | 2-15 | | McCullers, L | R | McCullers, L | | Gonzales, M | L |
| 8/21/2021 | | @ | LAD | W | 4-3 | | Mize, C | R | Jackson, L | Brogdon, C | Houser, A | R |
| 8/21/2021 | | | Was | L | 2-7 | | Senzatela, A | R | Senzatela, A | | Hendricks, K | R |
| 8/22/2021 | | @ | LAD | W | 7-2 | | McCullers, L | R | McCullers, L | | Snell, B | L |
| 8/22/2021 | | | Was | L | 6-11 | | Montgomery, J | L | Montgomery, J | | Foster, M | R |
| 8/23/2021 | | | Atl | L | 3-7 | | Mize, C | R | Mize, C | | Milone, T | L |
| 8/23/2021 | | @ | SF | W | 8-1 | | Senzatela, A | R | Senzatela, A | | Chatwood, T | R |
| 8/24/2021 | | | Atl | W | 5-4 | | Davies, Z | R | Davies, Z | Raley, B | LeBlanc, W | L |
| 8/24/2021 | | @ | SF | L | 3-4 | | Montgomery, J | L | Montgomery, J | | Wheeler, Z | R |
| 8/25/2021 | | | Atl | W | 14-4 | | McCullers, L | R | McCullers, L | | Mazza, C | R |
| 8/25/2021 | | @ | SF | L | 0-6 | | Sandoval, P | L | Sandoval, P | | Peterson, D | L |
| 8/27/2021 | | | Phi | W | 5-2 | | Senzatela, A | R | Senzatela, A | | Sheffield, J | L |
| 8/27/2021 | | @ | SD | W | 15-6 | | Mize, C | R | Mize, C | | Perez, M | L |
| 8/28/2021 | | | Phi | W | 5-4 | 10 | Montgomery, J | L | Tate, D | | Schmidt, C | R |
| 8/28/2021 | | @ | SD | L | 5-16 | | McCullers, L | R | McCullers, L | | Cease, D | R |
| 8/29/2021 | | | Phi | L | 2-8 | | Davies, Z | R | Osich, J | | Manaea, S | L |
| 8/29/2021 | | @ | SD | L | 3-4 | 11 | Montgomery, J | L | Raley, B | | Giolito, L | R |
| 9/13/2021 | | | Cin | W | 5-2 | | Davies, Z | R | Davies, Z | Brogdon, C | Strasburg, S | R |
| 9/13/2021 | | @ | StL | L | 3-8 | | Davies, Z | R | Davies, Z | | Carrasco, C | R |
| 9/14/2021 | | | Cin | L | 2-4 | | Senzatela, A | R | Brogdon, C | | Berrios, J | R |
| 9/14/2021 | | @ | StL | L | 0-1 | | Senzatela, A | R | Senzatela, A | | Heaney, A | L |
| 9/15/2021 | | | Cin | L | 6-11 | | Montgomery, J | L | Montgomery, J | | Woodruff, B | R |
| 9/15/2021 | | @ | StL | L | 4-10 | | Mize, C | R | Mize, C | | Ray, R | L |
| 9/17/2021 | | @ | ChC | L | 5-6 | | Montgomery, J | L | Raley, B | | Kelly, J | R |
| 9/17/2021 | | | Mil | W | 7-2 | | McCullers, L | R | McCullers, L | | Smith, C | L |
| 9/18/2021 | | @ | ChC | L | 0-9 | | Davies, Z | R | Davies, Z | | Keuchel, D | L |
| 9/18/2021 | | | Mil | L | 2-8 | | Davies, Z | R | Davies, Z | | Brault, S | L |
| 9/19/2021 | | @ | ChC | L | 3-5 | | Senzatela, A | R | Senzatela, A | | Greinke, Z | R |
| 9/19/2021 | | | Mil | W | 6-4 | | Senzatela, A | R | Senzatela, A | Tate, D | Gonsolin, T | R |
| 9/20/2021 | | | ChC | L | 2-6 | | Montgomery, J | L | Montgomery, J | | Kelly, J | R |
| 9/20/2021 | | @ | Mil | L | 5-6 | 10 | Mize, C | R | Brogdon, C | | Morton, C | R |
| 9/21/2021 | | | ChC | L | 2-3 | | Mize, C | R | Mize, C | | King, M | R |
| 9/21/2021 | | @ | Mil | L | 4-13 | | McCullers, L | R | McCullers, L | | Brault, S | L |
| 9/22/2021 | | | ChC | L | 4-5 | | Davies, Z | R | Davies, Z | | Montas, F | R |
| 9/22/2021 | | @ | Mil | W | 5-0 | | Davies, Z | R | Davies, Z | Helsley, R | Richards, G | R |
| 9/24/2021 | | @ | Cin | L | 3-4 | | Montgomery, J | L | Montgomery, J | | Plesac, Z | R |
| 9/24/2021 | | | StL | W | 4-1 | | McCullers, L | R | McCullers, L | Brogdon, C | Harvey, M | R |
| 9/25/2021 | | @ | Cin | L | 0-7 | | Senzatela, A | R | Senzatela, A | | Berrios, J | R |
| 9/25/2021 | | | StL | W | 4-3 | | Senzatela, A | R | Helsley, R | Tate, D | Ray, R | L |
| 9/26/2021 | | @ | Cin | W | 4-3 | 10 | McCullers, L | R | Osich, J | Raley, B | Lyles, J | R |
| 9/26/2021 | | | StL | W | 4-3 | | Mize, C | R | Mize, C | Schreiber, J | Heaney, A | L |
| Other |
| | | | | | | | | Cumulative |
| Date | # | | Opp | | GWRBI | RF | RA | W | L | Pct | Last10 | Strk | Gm# |
| 4/15/2021 | | @ | Cin | L | | 1 | 4 | 0 | 1 | .000 | 0-1 | L1 | 1 |
| 4/15/2021 | | | StL | W | Peterson, J | 4 | 1 | 1 | 1 | .500 | 1-1 | W1 | 2 |
| 4/16/2021 | | @ | Cin | L | | 5 | 13 | 1 | 2 | .333 | 1-2 | L1 | 3 |
| 4/16/2021 | | | StL | W | Piscotty, S | 4 | 2 | 2 | 2 | .500 | 2-2 | W1 | 4 |
| 4/17/2021 | | @ | Cin | L | | 6 | 7 | 2 | 3 | .400 | 2-3 | L1 | 5 |
| 4/17/2021 | | | StL | W | Galvis, F | 3 | 0 | 3 | 3 | .500 | 3-3 | W1 | 6 |
| 4/19/2021 | | | ChC | L | | 4 | 13 | 3 | 4 | .429 | 3-4 | L1 | 7 |
| 4/19/2021 | | @ | Mil | L | | 2 | 5 | 3 | 5 | .375 | 3-5 | L2 | 8 |
| 4/20/2021 | | | ChC | W | Gamel, B | 5 | 3 | 4 | 5 | .444 | 4-5 | W1 | 9 |
| 4/20/2021 | | @ | Mil | L | | 3 | 5 | 4 | 6 | .400 | 4-6 | L1 | 10 |
| 4/21/2021 | | | ChC | L | | 3 | 4 | 4 | 7 | .364 | 4-6 | L2 | 11 |
| 4/21/2021 | | @ | Mil | L | | 4 | 5 | 4 | 8 | .333 | 3-7 | L3 | 12 |
| 4/22/2021 | | @ | ChC | W | Piscotty, S | 3 | 1 | 5 | 8 | .385 | 4-6 | W1 | 13 |
| 4/22/2021 | | | Mil | W | Galvis, F | 7 | 4 | 6 | 8 | .429 | 4-6 | W2 | 14 |
| 4/23/2021 | | @ | ChC | L | | 3 | 4 | 6 | 9 | .400 | 4-6 | L1 | 15 |
| 4/23/2021 | | | Mil | W | Hiura, K | 1 | 0 | 7 | 9 | .438 | 4-6 | W1 | 16 |
| 4/24/2021 | | @ | ChC | L | | 3 | 9 | 7 | 10 | .412 | 4-6 | L1 | 17 |
| 4/24/2021 | | | Mil | L | | 2 | 3 | 7 | 11 | .389 | 4-6 | L2 | 18 |
| 4/26/2021 | | | Cin | L | | 3 | 9 | 7 | 12 | .368 | 3-7 | L3 | 19 |
| 4/26/2021 | | @ | StL | L | | 5 | 6 | 7 | 13 | .350 | 3-7 | L4 | 20 |
| 4/27/2021 | | | Cin | W | Piscotty, S | 5 | 4 | 8 | 13 | .381 | 4-6 | W1 | 21 |
| 4/27/2021 | | @ | StL | L | | 3 | 4 | 8 | 14 | .364 | 4-6 | L1 | 22 |
| 4/28/2021 | | | Cin | L | | 2 | 4 | 8 | 15 | .348 | 3-7 | L2 | 23 |
| 4/28/2021 | | @ | StL | W | Solano, D | 8 | 3 | 9 | 15 | .375 | 3-7 | W1 | 24 |
| 5/13/2021 | | | Bos | L | | 1 | 12 | 9 | 16 | .360 | 3-7 | L1 | 25 |
| 5/13/2021 | | @ | Sea | L | | 3 | 10 | 9 | 17 | .346 | 2-8 | L2 | 26 |
| 5/14/2021 | | | Bos | L | | 1 | 2 | 9 | 18 | .333 | 2-8 | L3 | 27 |
| 5/14/2021 | | @ | Sea | L | | 6 | 11 | 9 | 19 | .321 | 2-8 | L4 | 28 |
| 5/15/2021 | | | Bos | L | | 2 | 8 | 9 | 20 | .310 | 2-8 | L5 | 29 |
| 5/15/2021 | | @ | Sea | L | | 4 | 12 | 9 | 21 | .300 | 2-8 | L6 | 30 |
| 5/17/2021 | | @ | Hou | L | | 5 | 6 | 9 | 22 | .290 | 1-9 | L7 | 31 |
| 5/17/2021 | | | NYY | L | | 5 | 7 | 9 | 23 | .281 | 1-9 | L8 | 32 |
| 5/18/2021 | | @ | Hou | L | | 1 | 7 | 9 | 24 | .273 | 1-9 | L9 | 33 |
| 5/18/2021 | | | NYY | L | | 0 | 5 | 9 | 25 | .265 | 0-10 | L10 | 34 |
| 5/19/2021 | | @ | Hou | L | | 1 | 3 | 9 | 26 | .257 | 0-10 | L11 | 35 |
| 5/19/2021 | | | NYY | L | | 5 | 7 | 9 | 27 | .250 | 0-10 | L12 | 36 |
| 5/21/2021 | | | TB | W | Dahl, D | 15 | 1 | 10 | 27 | .270 | 1-9 | W1 | 37 |
| 5/21/2021 | | @ | Oak | L | | 0 | 11 | 10 | 28 | .263 | 1-9 | L1 | 38 |
| 5/22/2021 | | | TB | L | | 2 | 4 | 10 | 29 | .256 | 1-9 | L2 | 39 |
| 5/22/2021 | | @ | Oak | L | | 4 | 9 | 10 | 30 | .250 | 1-9 | L3 | 40 |
| 5/23/2021 | | | TB | W | Galvis, F | 1 | 0 | 11 | 30 | .268 | 2-8 | W1 | 41 |
| 5/23/2021 | | @ | Oak | L | | 5 | 7 | 11 | 31 | .262 | 2-8 | L1 | 42 |
| 5/24/2021 | | | Tor | W | Gordon, D | 11 | 6 | 12 | 31 | .279 | 3-7 | W1 | 43 |
| 5/24/2021 | | @ | LAA | L | | 6 | 14 | 12 | 32 | .273 | 3-7 | L1 | 44 |
| 5/25/2021 | | | Tor | L | | 4 | 12 | 12 | 33 | .267 | 3-7 | L2 | 45 |
| 5/25/2021 | | @ | LAA | L | | 1 | 4 | 12 | 34 | .261 | 3-7 | L3 | 46 |
| 5/26/2021 | | | Tor | W | Severino, P | 12 | 0 | 13 | 34 | .277 | 3-7 | W1 | 47 |
| 5/26/2021 | | @ | LAA | L | | 3 | 5 | 13 | 35 | .271 | 3-7 | L1 | 48 |
| 5/28/2021 | | | Bal | L | | 5 | 6 | 13 | 36 | .265 | 3-7 | L2 | 49 |
| 5/28/2021 | | @ | Tex | W | Galvis, F | 6 | 4 | 14 | 36 | .280 | 4-6 | W1 | 50 |
| 5/29/2021 | | | Bal | L | | 4 | 10 | 14 | 37 | .275 | 3-7 | L1 | 51 |
| 5/29/2021 | | @ | Tex | W | Peterson, J | 6 | 3 | 15 | 37 | .288 | 4-6 | W1 | 52 |
| 5/30/2021 | | | Bal | L | | 4 | 10 | 15 | 38 | .283 | 3-7 | L1 | 53 |
| 5/30/2021 | | @ | Tex | W | Galvis, F | 4 | 1 | 16 | 38 | .296 | 4-6 | W1 | 54 |
| 6/14/2021 | | @ | Phi | L | | 0 | 3 | 16 | 39 | .291 | 4-6 | L1 | 55 |
| 6/14/2021 | | | SD | L | | 1 | 2 | 16 | 40 | .286 | 4-6 | L2 | 56 |
| 6/15/2021 | | @ | Phi | L | | 1 | 2 | 16 | 41 | .281 | 3-7 | L3 | 57 |
| 6/15/2021 | | | SD | W | Reddick, J | 5 | 3 | 17 | 41 | .293 | 4-6 | W1 | 58 |
| 6/16/2021 | | @ | Phi | L | | 5 | 6 | 17 | 42 | .288 | 4-6 | L1 | 59 |
| 6/16/2021 | | | SD | W | Cooper, G | 6 | 0 | 18 | 42 | .300 | 4-6 | W1 | 60 |
| 6/17/2021 | | @ | Atl | L | | 2 | 5 | 18 | 43 | .295 | 4-6 | L1 | 61 |
| 6/17/2021 | | | LAD | W | | 3 | 2 | 19 | 43 | .306 | 4-6 | W1 | 62 |
| 6/18/2021 | | @ | Atl | L | | 0 | 18 | 19 | 44 | .302 | 4-6 | L1 | 63 |
| 6/18/2021 | | | LAD | W | Dahl, D | 5 | 3 | 20 | 44 | .313 | 4-6 | W1 | 64 |
| 6/19/2021 | | @ | Atl | W | Hiura, K | 3 | 2 | 21 | 44 | .323 | 5-5 | W2 | 65 |
| 6/19/2021 | | | LAD | W | Solano, D | 10 | 5 | 22 | 44 | .333 | 6-4 | W3 | 66 |
| 6/21/2021 | | @ | NYM | W | Galvis, F | 4 | 2 | 23 | 44 | .343 | 7-3 | W4 | 67 |
| 6/21/2021 | | | Ari | W | Casali, C | 4 | 0 | 24 | 44 | .353 | 7-3 | W5 | 68 |
| 6/22/2021 | | @ | NYM | W | Galvis, F | 5 | 4 | 25 | 44 | .362 | 8-2 | W6 | 69 |
| 6/22/2021 | | | Ari | W | Dahl, D | 6 | 2 | 26 | 44 | .371 | 8-2 | W7 | 70 |
| 6/23/2021 | | @ | NYM | L | | 6 | 7 | 26 | 45 | .366 | 8-2 | L1 | 71 |
| 6/23/2021 | | | Ari | W | Solano, D | 4 | 1 | 27 | 45 | .375 | 8-2 | W1 | 72 |
| 6/24/2021 | | @ | Was | L | | 5 | 10 | 27 | 46 | .370 | 8-2 | L1 | 73 |
| 6/24/2021 | | | Col | L | | 3 | 8 | 27 | 47 | .365 | 7-3 | L2 | 74 |
| 6/25/2021 | | @ | Was | L | | 2 | 6 | 27 | 48 | .360 | 6-4 | L3 | 75 |
| 6/25/2021 | | | Col | L | | 3 | 4 | 27 | 49 | .355 | 5-5 | L4 | 76 |
| 6/26/2021 | | @ | Was | L | | 6 | 12 | 27 | 50 | .351 | 4-6 | L5 | 77 |
| 6/26/2021 | | | Col | L | | 1 | 10 | 27 | 51 | .346 | 3-7 | L6 | 78 |
| 6/28/2021 | | | SF | W | Solano, D | 2 | 1 | 28 | 51 | .354 | 3-7 | W1 | 79 |
| 6/28/2021 | | @ | Mia | L | | 1 | 2 | 28 | 52 | .350 | 2-8 | L1 | 80 |
| 6/29/2021 | | | SF | W | Peterson, J | 9 | 1 | 29 | 52 | .358 | 3-7 | W1 | 81 |
| 6/29/2021 | | @ | Mia | L | | 1 | 5 | 29 | 53 | .354 | 2-8 | L1 | 82 |
| 6/30/2021 | | | SF | W | Solano, D | 4 | 0 | 30 | 53 | .361 | 3-7 | W1 | 83 |
| 6/30/2021 | | @ | Mia | L | | 1 | 2 | 30 | 54 | .357 | 3-7 | L1 | 84 |
| 7/15/2021 | | | ChC | L | | 7 | 12 | 30 | 55 | .353 | 3-7 | L2 | 85 |
| 7/15/2021 | | @ | Mil | L | | 4 | 9 | 30 | 56 | .349 | 3-7 | L3 | 86 |
| 7/16/2021 | | | ChC | L | | 2 | 7 | 30 | 57 | .345 | 3-7 | L4 | 87 |
| 7/16/2021 | | @ | Mil | L | | 0 | 4 | 30 | 58 | .341 | 3-7 | L5 | 88 |
| 7/17/2021 | | | ChC | W | Hiura, K | 5 | 3 | 31 | 58 | .348 | 3-7 | W1 | 89 |
| 7/17/2021 | | @ | Mil | W | Guillorme, L | 9 | 3 | 32 | 58 | .356 | 4-6 | W2 | 90 |
| 7/19/2021 | | | Cin | W | Severino, P | 8 | 0 | 33 | 58 | .363 | 4-6 | W3 | 91 |
| 7/19/2021 | | @ | StL | L | | 4 | 5 | 33 | 59 | .359 | 4-6 | L1 | 92 |
| 7/20/2021 | | | Cin | L | | 3 | 8 | 33 | 60 | .355 | 3-7 | L2 | 93 |
| 7/20/2021 | | @ | StL | W | Gamel, B | 3 | 2 | 34 | 60 | .362 | 4-6 | W1 | 94 |
| 7/21/2021 | | | Cin | W | Severino, P | 7 | 5 | 35 | 60 | .368 | 5-5 | W2 | 95 |
| 7/21/2021 | | @ | StL | L | | 0 | 3 | 35 | 61 | .365 | 5-5 | L1 | 96 |
| 7/22/2021 | | @ | Cin | L | | 1 | 5 | 35 | 62 | .361 | 5-5 | L2 | 97 |
| 7/22/2021 | | | StL | W | Gamel, B | 8 | 6 | 36 | 62 | .367 | 6-4 | W1 | 98 |
| 7/23/2021 | | @ | Cin | W | Gordon, D | 12 | 5 | 37 | 62 | .374 | 6-4 | W2 | 99 |
| 7/23/2021 | | | StL | L | | 4 | 6 | 37 | 63 | .370 | 5-5 | L1 | 100 |
| 7/24/2021 | | @ | Cin | L | | 2 | 7 | 37 | 64 | .366 | 4-6 | L2 | 101 |
| 7/24/2021 | | | StL | W | Peterson, J | 5 | 2 | 38 | 64 | .373 | 5-5 | W1 | 102 |
| 7/26/2021 | | @ | ChC | L | | 1 | 7 | 38 | 65 | .369 | 5-5 | L1 | 103 |
| 7/26/2021 | | | Mil | W | Reddick, J | 10 | 9 | 39 | 65 | .375 | 5-5 | W1 | 104 |
| 7/27/2021 | | @ | ChC | L | | 6 | 12 | 39 | 66 | .371 | 4-6 | L1 | 105 |
| 7/27/2021 | | | Mil | L | | 1 | 10 | 39 | 67 | .368 | 4-6 | L2 | 106 |
| 7/28/2021 | | @ | ChC | L | | 4 | 7 | 39 | 68 | .364 | 4-6 | L3 | 107 |
| 7/28/2021 | | | Mil | L | | 8 | 10 | 39 | 69 | .361 | 3-7 | L4 | 108 |
| 8/13/2021 | | | NYM | W | Hiura, K | 8 | 7 | 40 | 69 | .367 | 3-7 | W1 | 109 |
| 8/13/2021 | | @ | Ari | L | | 3 | 5 | 40 | 70 | .364 | 3-7 | L1 | 110 |
| 8/14/2021 | | | NYM | W | Taylor, T | 10 | 0 | 41 | 70 | .369 | 4-6 | W1 | 111 |
| 8/14/2021 | | @ | Ari | W | Solano, D | 3 | 1 | 42 | 70 | .375 | 4-6 | W2 | 112 |
| 8/15/2021 | | | NYM | W | Cooper, G | 4 | 3 | 43 | 70 | .381 | 5-5 | W3 | 113 |
| 8/15/2021 | | @ | Ari | L | | 4 | 7 | 43 | 71 | .377 | 4-6 | L1 | 114 |
| 8/16/2021 | | | Mia | L | | 1 | 8 | 43 | 72 | .374 | 4-6 | L2 | 115 |
| 8/16/2021 | | @ | Col | L | | 7 | 13 | 43 | 73 | .371 | 4-6 | L3 | 116 |
| 8/17/2021 | | | Mia | W | Guillorme, L | 3 | 2 | 44 | 73 | .376 | 5-5 | W1 | 117 |
| 8/17/2021 | | @ | Col | L | | 4 | 5 | 44 | 74 | .373 | 5-5 | L1 | 118 |
| 8/18/2021 | | | Mia | L | | 0 | 1 | 44 | 75 | .370 | 4-6 | L2 | 119 |
| 8/18/2021 | | @ | Col | L | | 5 | 9 | 44 | 76 | .367 | 4-6 | L3 | 120 |
| 8/20/2021 | | @ | LAD | L | | 1 | 5 | 44 | 77 | .364 | 3-7 | L4 | 121 |
| 8/20/2021 | | | Was | L | | 2 | 15 | 44 | 78 | .361 | 2-8 | L5 | 122 |
| 8/21/2021 | | @ | LAD | W | | 4 | 3 | 45 | 78 | .366 | 2-8 | W1 | 123 |
| 8/21/2021 | | | Was | L | | 2 | 7 | 45 | 79 | .363 | 2-8 | L1 | 124 |
| 8/22/2021 | | @ | LAD | W | Cooper, G | 7 | 2 | 46 | 79 | .368 | 3-7 | W1 | 125 |
| 8/22/2021 | | | Was | L | | 6 | 11 | 46 | 80 | .365 | 3-7 | L1 | 126 |
| 8/23/2021 | | | Atl | L | | 3 | 7 | 46 | 81 | .362 | 2-8 | L2 | 127 |
| 8/23/2021 | | @ | SF | W | Solano, D | 8 | 1 | 47 | 81 | .367 | 3-7 | W1 | 128 |
| 8/24/2021 | | | Atl | W | | 5 | 4 | 48 | 81 | .372 | 4-6 | W2 | 129 |
| 8/24/2021 | | @ | SF | L | | 3 | 4 | 48 | 82 | .369 | 4-6 | L1 | 130 |
| 8/25/2021 | | | Atl | W | Cooper, G | 14 | 4 | 49 | 82 | .374 | 5-5 | W1 | 131 |
| 8/25/2021 | | @ | SF | L | | 0 | 6 | 49 | 83 | .371 | 5-5 | L1 | 132 |
| 8/27/2021 | | | Phi | W | Severino, P | 5 | 2 | 50 | 83 | .376 | 5-5 | W1 | 133 |
| 8/27/2021 | | @ | SD | W | Guillorme, L | 15 | 6 | 51 | 83 | .381 | 6-4 | W2 | 134 |
| 8/28/2021 | | | Phi | W | Cooper, G | 5 | 4 | 52 | 83 | .385 | 6-4 | W3 | 135 |
| 8/28/2021 | | @ | SD | L | | 5 | 16 | 52 | 84 | .382 | 6-4 | L1 | 136 |
| 8/29/2021 | | | Phi | L | | 2 | 8 | 52 | 85 | .380 | 6-4 | L2 | 137 |
| 8/29/2021 | | @ | SD | L | | 3 | 4 | 52 | 86 | .377 | 5-5 | L3 | 138 |
| 9/13/2021 | | | Cin | W | Galvis, F | 5 | 2 | 53 | 86 | .381 | 5-5 | W1 | 139 |
| 9/13/2021 | | @ | StL | L | | 3 | 8 | 53 | 87 | .379 | 5-5 | L1 | 140 |
| 9/14/2021 | | | Cin | L | | 2 | 4 | 53 | 88 | .376 | 4-6 | L2 | 141 |
| 9/14/2021 | | @ | StL | L | | 0 | 1 | 53 | 89 | .373 | 4-6 | L3 | 142 |
| 9/15/2021 | | | Cin | L | | 6 | 11 | 53 | 90 | .371 | 3-7 | L4 | 143 |
| 9/15/2021 | | @ | StL | L | | 4 | 10 | 53 | 91 | .368 | 2-8 | L5 | 144 |
| 9/17/2021 | | @ | ChC | L | | 5 | 6 | 53 | 92 | .366 | 1-9 | L6 | 145 |
| 9/17/2021 | | | Mil | W | Cooper, G | 7 | 2 | 54 | 92 | .370 | 2-8 | W1 | 146 |
| 9/18/2021 | | @ | ChC | L | | 0 | 9 | 54 | 93 | .367 | 2-8 | L1 | 147 |
| 9/18/2021 | | | Mil | L | | 2 | 8 | 54 | 94 | .365 | 2-8 | L2 | 148 |
| 9/19/2021 | | @ | ChC | L | | 3 | 5 | 54 | 95 | .362 | 1-9 | L3 | 149 |
| 9/19/2021 | | | Mil | W | Solano, D | 6 | 4 | 55 | 95 | .367 | 2-8 | W1 | 150 |
| 9/20/2021 | | | ChC | L | | 2 | 6 | 55 | 96 | .364 | 2-8 | L1 | 151 |
| 9/20/2021 | | @ | Mil | L | | 5 | 6 | 55 | 97 | .362 | 2-8 | L2 | 152 |
| 9/21/2021 | | | ChC | L | | 2 | 3 | 55 | 98 | .359 | 2-8 | L3 | 153 |
| 9/21/2021 | | @ | Mil | L | | 4 | 13 | 55 | 99 | .357 | 2-8 | L4 | 154 |
| 9/22/2021 | | | ChC | L | | 4 | 5 | 55 | 100 | .355 | 2-8 | L5 | 155 |
| 9/22/2021 | | @ | Mil | W | Cooper, G | 5 | 0 | 56 | 100 | .359 | 2-8 | W1 | 156 |
| 9/24/2021 | | @ | Cin | L | | 3 | 4 | 56 | 101 | .357 | 2-8 | L1 | 157 |
| 9/24/2021 | | | StL | W | Gamel, B | 4 | 1 | 57 | 101 | .361 | 3-7 | W1 | 158 |
| 9/25/2021 | | @ | Cin | L | | 0 | 7 | 57 | 102 | .358 | 3-7 | L1 | 159 |
| 9/25/2021 | | | StL | W | Solano, D | 4 | 3 | 58 | 102 | .363 | 3-7 | W1 | 160 |
| 9/26/2021 | | @ | Cin | W | Solano, D | 4 | 3 | 59 | 102 | .366 | 4-6 | W2 | 161 |
| 9/26/2021 | | | StL | W | Solano, D | 4 | 3 | 60 | 102 | .370 | 5-5 | W3 | 162 |