League injury log -- American League
Regular season -- as of 10/30/2021
| Injuries |
| Date | # | Team | Player | Cause | Dur |
| 4/15/2021 | | Bos | Javier | General | 16 |
| 4/15/2021 | | Tor | Miley | General | 21 |
| 4/15/2021 | | ChW | McNeil | Hit by pitch | 1 |
| 4/15/2021 | | Sea | Minor | General | 21 |
| 4/15/2021 | | Oak | Harrison,J | General | 1 |
| 4/16/2021 | | Bal | Hernandez,T | General | 15 |
| 4/16/2021 | | Bos | Javier | General | 12 |
| 4/16/2021 | | Det | Turner,J | General | 3 |
| 4/16/2021 | | Sea | Baez,J | General | 13 |
| 4/16/2021 | | Sea | May,T | General | 3 |
| 4/17/2021 | | Bos | Perez,S | General | 1 |
| 4/17/2021 | | Tor | Donaldson | General | 6 |
| 4/17/2021 | | Tor | Foltynewicz | General | 11 |
| 4/17/2021 | | Oak | Wieck | General | 1 |
| 4/17/2021 | | Sea | Fedde | General | 6 |
| 4/19/2021 | | TB | Allen,L | General | 6 |
| 4/19/2021 | | ChW | Freeland | General | 1 |
| 4/20/2021 | | Tor | Conforto | General | 1 |
| 4/20/2021 | | NYY | Burnes | General | 1 |
| 4/20/2021 | | TB | Robles,V | General | 7 |
| 4/20/2021 | | Cle | Gilbreath | General | 1 |
| 4/20/2021 | | Tex | Hearn | General | 16 |
| 4/21/2021 | | Bos | Flores,W | General | 8 |
| 4/21/2021 | | Cle | Bichette | General | 1 |
| 4/21/2021 | | Det | Greinke | General | 1 |
| 4/22/2021 | | Det | Turner,J | General | 1 |
| 4/22/2021 | | LAA | McCormick | Hit by pitch | 1 |
| 4/22/2021 | | Tex | Quinn | General | 3 |
| 4/23/2021 | | TB | Perez,Ma | General | 16 |
| 4/23/2021 | | ChW | Tucker,C | General | 5 |
| 4/23/2021 | | Hou | Barnhart | General | 17 |
| 4/24/2021 | | Oak | Mancini | General | 1 |
| 4/26/2021 | | NYY | Garcia,Ad | General | 1 |
| 4/27/2021 | | Bos | Flores,W | General | 11 |
| 4/27/2021 | | NYY | Madrigal | General | 16 |
| 4/27/2021 | | Bos | Grossman | General | 2 |
| 4/27/2021 | | LAA | Beaty | Hit by pitch | 1 |
| 4/27/2021 | | Oak | Warren,Ar | General | 1 |
| 4/28/2021 | | Tor | Judge | Hit by pitch | 1 |
| 4/28/2021 | | Tex | Quinn | General | 19 |
| 5/13/2021 | | Bal | Chafin | General | 1 |
| 5/13/2021 | | Bal | Urias,J | General | 11 |
| 5/13/2021 | | Tor | Donaldson | Hit by pitch | 27 |
| 5/13/2021 | | Cle | Suzuki | Hit by pitch | 34 |
| 5/13/2021 | | Sea | Alonso | General | 5 |
| 5/14/2021 | | Bos | Arraez | General | 22 |
| 5/14/2021 | | Cle | Bichette | General | 1 |
| 5/15/2021 | | Bal | Hayes | Hit by pitch | 14 |
| 5/15/2021 | | Bos | Petit | General | 1 |
| 5/15/2021 | | Tor | Judge | Hit by pitch | 15 |
| 5/15/2021 | | ChW | Kepler | General | 10 |
| 5/15/2021 | | ChW | McNeil | General | 4 |
| 5/15/2021 | | Det | Vogt | General | 6 |
| 5/15/2021 | | LAA | Darvish | General | 16 |
| 5/15/2021 | | Hou | Story | Hit by pitch | 1 |
| 5/17/2021 | | Bal | Arozarena | Hit by pitch | 14 |
| 5/17/2021 | | NYY | Gonzalez,M | General | 7 |
| 5/17/2021 | | TB | Anderson,Bre | General | 21 |
| 5/17/2021 | | Min | Swanson,D | General | 1 |
| 5/17/2021 | | LAA | Vazquez | General | 1 |
| 5/18/2021 | | Bal | Walsh | General | 18 |
| 5/18/2021 | | Oak | Mancini | General | 5 |
| 5/19/2021 | | TB | Renfroe | General | 1 |
| 5/19/2021 | | LAA | Escobar,A | Hit by pitch | 2 |
| 5/19/2021 | | Sea | Alonso | General | 10 |
| 5/21/2021 | | Bal | Hernandez,T | General | 15 |
| 5/21/2021 | | Cle | Hoskins | General | 1 |
| 5/21/2021 | | Cle | Jankowski | General | 29 |
| 5/21/2021 | | KC | Guerrero | General | 1 |
| 5/21/2021 | | Min | Verdugo | General | 12 |
| 5/21/2021 | | Sea | Hill,D | Hit by pitch | 25 |
| 5/21/2021 | | Tex | Martinez,JD | General | 2 |
| 5/21/2021 | | Tex | Martinez,JD | General | 1 |
| 5/22/2021 | | Bal | Arozarena | General | 4 |
| 5/22/2021 | | TB | Garrett,B | General | 1 |
| 5/22/2021 | | ChW | Misiewicz | General | 1 |
| 5/22/2021 | | Tex | Sawamura | General | 14 |
| 5/23/2021 | | NYY | Martin,Ch | General | 8 |
| 5/23/2021 | | ChW | Sale | General | 1 |
| 5/23/2021 | | Cle | Gilbreath | Brawl | 17 |
| 5/23/2021 | | Oak | Heredia | Hit by pitch | 1 |
| 5/24/2021 | | Bos | Javier | General | 11 |
| 5/24/2021 | | Bos | Petit | General | 1 |
| 5/24/2021 | | Bos | Fletcher,D | General | 1 |
| 5/24/2021 | | ChW | Reyes,A | General | 3 |
| 5/24/2021 | | Tex | Martinez,JD | Hit by pitch | 15 |
| 5/24/2021 | | Tex | Williams,L | General | 13 |
| 5/25/2021 | | NYY | Thomas,L | General | 12 |
| 5/25/2021 | | KC | Villar | General | 16 |
| 5/25/2021 | | Oak | Dobnak | Brawl | 27 |
| 5/25/2021 | | Oak | Mercedes | Brawl | 12 |
| 5/26/2021 | | Min | Floro | General | 1 |
| 5/26/2021 | | Sea | Alonso | General | 7 |
| 5/28/2021 | | Bos | Grossman | Hit by pitch | 1 |
| 5/28/2021 | | ChW | Rizzo | Hit by pitch | 4 |
| 5/28/2021 | | Det | Loup | General | 1 |
| 5/28/2021 | | Min | Allard | General | 6 |
| 5/28/2021 | | LAA | Escobar,A | General | 3 |
| 5/28/2021 | | Hou | Hand | General | 1 |
| 5/29/2021 | | Min | Bregman | General | 4 |
| 5/30/2021 | | Bos | Davis,JD | General | 8 |
| 5/30/2021 | | Tor | Hentges | General | 1 |
| 5/30/2021 | | Det | Castellanos,N | General | 1 |
| 5/30/2021 | | Hou | Hand | General | 1 |
| 6/14/2021 | | Sea | LeMahieu | General | 7 |
| 6/15/2021 | | Det | Abreu,J | General | 10 |
| 6/15/2021 | | Hou | Bryant | General | 5 |
| 6/16/2021 | | Hou | Holmes | General | 21 |
| 6/16/2021 | | NYY | Wong,Ko | General | 9 |
| 6/16/2021 | | Sea | Dickerson,A | General | 1 |
| 6/16/2021 | | LAA | Casali | General | 9 |
| 6/17/2021 | | Bos | Chacin | General | 4 |
| 6/17/2021 | | Bos | Ross | General | 1 |
| 6/17/2021 | | Sea | LeMahieu | General | 7 |
| 6/17/2021 | | ChW | Quantrill | General | 6 |
| 6/17/2021 | | Min | Bregman | General | 33 |
| 6/18/2021 | | ChW | Quantrill | General | 6 |
| 6/18/2021 | | Bos | Webb,L | General | 1 |
| 6/18/2021 | | NYY | Garcia,Ad | General | 3 |
| 6/18/2021 | | NYY | Hosmer | General | 11 |
| 6/18/2021 | | Tex | Whitley | General | 9 |
| 6/18/2021 | | Min | Barnes,M | General | 4 |
| 6/19/2021 | | Bal | Stanton | General | 7 |
| 6/19/2021 | | Bal | Urias,J | General | 26 |
| 6/19/2021 | | Tex | Gurriel,Y | General | 19 |
| 6/21/2021 | | Bos | Yastrzemski | General | 23 |
| 6/21/2021 | | Tor | Castro,H | General | 2 |
| 6/22/2021 | | Sea | Hill,D | General | 10 |
| 6/22/2021 | | Bos | Vogelbach | General | 24 |
| 6/22/2021 | | Det | Lester | General | 31 |
| 6/23/2021 | | Bos | Grossman | General | 4 |
| 6/23/2021 | | Min | Freeman,F | General | 3 |
| 6/23/2021 | | Bos | Chacin | General | 25 |
| 6/23/2021 | | Hou | Nogowski | General | 11 |
| 6/23/2021 | | Oak | Green | General | 2 |
| 6/23/2021 | | Cle | Crowe | General | 6 |
| 6/23/2021 | | Tex | Gurriel,Y | General | 19 |
| 6/24/2021 | | Bos | Perez,S | General | 1 |
| 6/24/2021 | | NYY | Lindor | General | 6 |
| 6/24/2021 | | Tor | Velasquez | General | 21 |
| 6/24/2021 | | KC | Cave | General | 10 |
| 6/24/2021 | | Oak | Peralta,D | General | 1 |
| 6/25/2021 | | Bal | Ward | General | 1 |
| 6/25/2021 | | TB | Bleier | General | 1 |
| 6/25/2021 | | Cle | Suzuki | Hit by pitch | 18 |
| 6/26/2021 | | Bal | Higashioka | Hit by pitch | 6 |
| 6/26/2021 | | Sea | Merrifield | General | 1 |
| 6/26/2021 | | Oak | Ortega,R | General | 12 |
| 6/28/2021 | | Bal | Chafin | General | 1 |
| 6/28/2021 | | Tex | Sawamura | General | 4 |
| 6/28/2021 | | KC | Smith,J | General | 1 |
| 6/28/2021 | | Hou | Gray,Jon | General | 1 |
| 6/28/2021 | | Sea | Merrifield | General | 1 |
| 6/28/2021 | | Sea | Skubal | General | 6 |
| 6/28/2021 | | ChW | Taylor,C | General | 1 |
| 6/29/2021 | | KC | Tsutsugo | General | 2 |
| 6/29/2021 | | Sea | Baez,J | General | 10 |
| 6/29/2021 | | Tex | Ruiz,J | General | 12 |
| 6/29/2021 | | Oak | Polanco,J | General | 5 |
| 6/30/2021 | | Tor | Margot | General | 1 |
| 6/30/2021 | | Min | Musgrove | General | 1 |
| 6/30/2021 | | Min | Tucker,K | General | 3 |
| 6/30/2021 | | Oak | Odor | General | 7 |
| 7/15/2021 | | ChW | Kiermaier | General | 8 |
| 7/15/2021 | | Cle | Kelenic | General | 2 |
| 7/15/2021 | | LAA | McCormick | Hit by pitch | 25 |
| 7/15/2021 | | Sea | Merrifield | General | 1 |
| 7/16/2021 | | TB | Hoerner | General | 7 |
| 7/16/2021 | | Bos | Grossman | Hit by pitch | 7 |
| 7/16/2021 | | Hou | Dubon | General | 1 |
| 7/17/2021 | | NYY | Lindor | Hit by pitch | 2 |
| 7/17/2021 | | NYY | Raley,L | General | 2 |
| 7/17/2021 | | ChW | Castro,J | Hit by pitch | 28 |
| 7/19/2021 | | Tor | Velasquez | General | 1 |
| 7/19/2021 | | KC | Arrieta | General | 1 |
| 7/19/2021 | | Sea | Arroyo | Hit by pitch | 24 |
| 7/19/2021 | | Tex | Hearn | General | 6 |
| 7/20/2021 | | TB | Anderson,Bre | General | 1 |
| 7/20/2021 | | Tor | Reyes,F | General | 19 |
| 7/20/2021 | | Sea | Arroyo | Hit by pitch | 1 |
| 7/21/2021 | | Bal | Mills,A | General | 1 |
| 7/21/2021 | | Cle | Bichette | General | 1 |
| 7/21/2021 | | Min | Barnes,M | General | 10 |
| 7/21/2021 | | Oak | Farmer,K | General | 6 |
| 7/21/2021 | | Sea | Minor | General | 11 |
| 7/21/2021 | | Tex | Stevenson | General | 1 |
| 7/21/2021 | | Hou | Walker,T | General | 1 |
| 7/22/2021 | | TB | Morejon | General | 41 |
| 7/22/2021 | | Cle | Castro,W | General | 5 |
| 7/22/2021 | | ChW | Anderson,Bri | Hit by pitch | 1 |
| 7/22/2021 | | Cle | Hembree | General | 1 |
| 7/22/2021 | | Min | Brubaker | General | 21 |
| 7/22/2021 | | Oak | Gibson | General | 1 |
| 7/23/2021 | | LAA | Beaty | General | 1 |
| 7/23/2021 | | LAA | Gomber | General | 21 |
| 7/23/2021 | | Oak | Harrison,J | General | 3 |
| 7/23/2021 | | Hou | Drury | General | 5 |
| 7/23/2021 | | Hou | Story | General | 16 |
| 7/24/2021 | | Tor | Cabrera,A | General | 1 |
| 7/24/2021 | | Tor | Velasquez | General | 16 |
| 7/24/2021 | | TB | Perez,Ma | General | 1 |
| 7/24/2021 | | LAA | Haniger | General | 1 |
| 7/26/2021 | | Tor | Velasquez | General | 31 |
| 7/26/2021 | | Cle | Shaw,T | General | 13 |
| 7/26/2021 | | Cle | Houck | General | 16 |
| 7/26/2021 | | Oak | Heredia | General | 14 |
| 7/26/2021 | | Hou | Bradley,B | Hit by pitch | 30 |
| 7/27/2021 | | Tor | Bumgarner | General | 26 |
| 7/27/2021 | | KC | Rivero | General | 1 |
| 7/28/2021 | | TB | Akiyama | General | 1 |
| 7/28/2021 | | Bos | Ruf | General | 14 |
| 7/28/2021 | | Bos | Vogelbach | General | 6 |
| 7/28/2021 | | Tor | France | Hit by pitch | 11 |
| 7/28/2021 | | KC | Gutierrez,V | General | 1 |
| 7/28/2021 | | Cle | Clay | General | 15 |
| 7/28/2021 | | Det | Abreu,J | Hit by pitch | 11 |
| 7/28/2021 | | Tex | Wells,A | General | 16 |
| 7/28/2021 | | Tex | Garcia,Ar | Hit by pitch | 32 |
| 7/28/2021 | | Hou | Bryant | General | 15 |
| 8/13/2021 | | Oak | Farmer,K | Hit by pitch | 1 |
| 8/14/2021 | | ChW | Kiermaier | General | 3 |
| 8/14/2021 | | TB | Garrett,B | General | 1 |
| 8/14/2021 | | KC | Joyce | General | 13 |
| 8/15/2021 | | Tex | Suarez,R | General | 1 |
| 8/16/2021 | | Det | Turner,T | General | 12 |
| 8/16/2021 | | Bos | Fletcher,D | General | 2 |
| 8/16/2021 | | NYY | Moustakas | General | 1 |
| 8/16/2021 | | Hou | Gray,Jon | General | 6 |
| 8/16/2021 | | TB | Canning | General | 1 |
| 8/16/2021 | | Tor | Cabrera,A | General | 5 |
| 8/16/2021 | | Hou | Barnhart | General | 17 |
| 8/16/2021 | | Tex | Flexen | General | 1 |
| 8/17/2021 | | Oak | Mancini | General | 10 |
| 8/18/2021 | | NYY | Duran | General | 1 |
| 8/18/2021 | | NYY | Hosmer | General | 1 |
| 8/18/2021 | | KC | Tsutsugo | Hit by pitch | 19 |
| 8/18/2021 | | TB | Gilbert,T | General | 21 |
| 8/18/2021 | | Tor | Norris | General | 1 |
| 8/20/2021 | | Bal | Cobb | General | 1 |
| 8/20/2021 | | LAA | Yarbrough | General | 1 |
| 8/21/2021 | | Oak | Polanco,J | General | 4 |
| 8/21/2021 | | Tor | Norris | General | 2 |
| 8/21/2021 | | Sea | Baez,J | General | 11 |
| 8/21/2021 | | Tex | Garcia,Ar | Hit by pitch | 1 |
| 8/21/2021 | | Min | Rodgers | General | 1 |
| 8/22/2021 | | Tex | Escobar,E | General | 12 |
| 8/22/2021 | | Tex | India | General | 4 |
| 8/22/2021 | | Oak | Polanco,J | General | 1 |
| 8/22/2021 | | Det | Lester | General | 21 |
| 8/22/2021 | | ChW | Kiermaier | General | 6 |
| 8/23/2021 | | Min | Verdugo | General | 6 |
| 8/24/2021 | | Min | Varsho | General | 2 |
| 8/24/2021 | | TB | Gilbert,T | General | 1 |
| 8/25/2021 | | Hou | Santana,Da | General | 9 |
| 8/25/2021 | | Det | Blackmon | General | 5 |
| 8/25/2021 | | Det | Greinke | General | 1 |
| 8/27/2021 | | Cle | Pop | General | 22 |
| 8/28/2021 | | Min | Varsho | General | 3 |
| 8/28/2021 | | Cle | Suzuki | Hit by pitch | 39 |
| 8/28/2021 | | ChW | Mayers | General | 1 |
| 8/29/2021 | | Tex | Rengifo | General | 18 |
| 8/29/2021 | | Cle | Marchan | General | 1 |
| 9/13/2021 | | Det | Turner,T | General | 4 |
| 9/13/2021 | | KC | Singer | General | 1 |
| 9/14/2021 | | Bos | Webb,L | General | 26 |
| 9/14/2021 | | Det | Santana,C | General | 1 |
| 9/14/2021 | | KC | Johnson,P | General | 14 |
| 9/14/2021 | | Min | Pache | General | 12 |
| 9/14/2021 | | Sea | d'Arnaud | General | 1 |
| 9/14/2021 | | Sea | Happ,I | General | 10 |
| 9/14/2021 | | LAA | Beaty | General | 3 |
| 9/14/2021 | | Hou | Hill,R | General | 1 |
| 9/14/2021 | | Hou | Santana,Da | General | 5 |
| 9/15/2021 | | Det | Turner,T | General | 4 |
| 9/15/2021 | | KC | Guerrero | General | 1 |
| 9/15/2021 | | Min | Brubaker | General | 16 |
| 9/15/2021 | | Tex | Nola,Au | General | 1 |
| 9/17/2021 | | Bal | Crawford,JP | General | 1 |
| 9/17/2021 | | Cle | Shaw,T | General | 7 |
| 9/17/2021 | | Oak | McCutchen | General | 1 |
| 9/17/2021 | | Sea | Contreras,WJ | Hit by pitch | 21 |
| 9/18/2021 | | KC | Segura | Hit by pitch | 1 |
| 9/19/2021 | | Tor | Newcomb | General | 2 |
| 9/19/2021 | | NYY | Lindor | General | 29 |
| 9/19/2021 | | TB | Renfroe | General | 1 |
| 9/19/2021 | | Det | Turner,J | Hit by pitch | 9 |
| 9/19/2021 | | Min | Rodgers | Hit by pitch | 1 |
| 9/20/2021 | | Bos | Perez,S | General | 1 |
| 9/20/2021 | | Tex | Gurriel,Y | Hit by pitch | 1 |
| 9/20/2021 | | Tex | India | General | 12 |
| 9/20/2021 | | Sea | Dickerson,A | Hit by pitch | 10 |
| 9/21/2021 | | Tor | Arihara | General | 11 |
| 9/21/2021 | | TB | Jimenez,E | General | 4 |
| 9/21/2021 | | NYY | Gonzalez,M | General | 7 |
| 9/21/2021 | | Tor | France | Collision on bases | 11 |
| 9/21/2021 | | KC | McGee | General | 11 |
| 9/21/2021 | | Min | Narvaez | Hit by pitch | 16 |
| 9/21/2021 | | LAA | Edman | General | 1 |
| 9/21/2021 | | LAA | Edman | General | 1 |
| 9/22/2021 | | Cle | Plesac | General | 11 |
| 9/22/2021 | | Cle | Doolittle | General | 15 |
| 9/22/2021 | | Tex | Ahmed | General | 12 |
| 9/24/2021 | | Min | Rodgers | Hit by pitch | 39 |
| 9/24/2021 | | Min | Bregman | Hit by pitch | 1 |
| 9/24/2021 | | Sea | Castro,M | General | 1 |
| 9/24/2021 | | Sea | Happ,I | Hit by pitch | 12 |
| 9/24/2021 | | Tex | Martinez,JD | General | 2 |
| 9/25/2021 | | Sea | Keller,B | General | 1 |
| 9/26/2021 | | Bal | Kemp | General | 1 |
| 9/26/2021 | | ChW | Freeland | General | 26 |
| 9/26/2021 | | Cle | Bichette | General | 1 |
| 9/26/2021 | | KC | Meadows | General | 1 |
| 10/6/2021 | | Oak | Anderson,Ty | General | 6 |
| 10/15/2021 | | Bos | Yastrzemski | General | 1 |
| 10/16/2021 | | Det | Turner,J | General | 1 |
| 10/19/2021 | | Det | Turner,T | General | 9 |