UsagePosition -- 2021 Chicago White Sox
Regular season -- as of 9/29/2021
| Batter Status |
| S | Name | P | G | FLG |
| | Brian Anderson | 3b | 159 | 159 |
| | Jason Castro | c | 73 | 114 |
| | Franchy Cordero | rf | 43 | 42 |
| | Khris Davis | dh | 81 | 83 |
| | Yandy Diaz | 3b | 92 | 101 |
| f | Derek Fisher | rf | 43 | 47 |
| | Austin Hedges | c | 95 | 40 |
| | Aaron Hicks | cf | 146 | 146 |
| | Kevin Kiermaier | cf | 132 | 128 |
| f | Vimael Machin | 3b | 65 | 40 |
| | Jeff McNeil | lf | 140 | 140 |
| | Tyler O'Neill | lf | 140 | 138 |
| | Roberto Perez | c | 86 | 79 |
| | Anthony Rizzo | 1b | 157 | 156 |
| f | Tyler Stephenson | c | 22 | 24 |
| | Chris Taylor | ss | 151 | 151 |
| | Gleyber Torres | ss | 113 | 124 |
| | Cole Tucker | cf | 100 | 55 |
| | Total | | 1838 | 1767 |
| Pitcher Status |
| S | Name | P | G | FLG | GS | FLGS |
| | Kyle Freeland | sp | 35 | 36 | 35 | 36 |
| f | Luke Weaver | sp | 32 | 16 | 32 | 16 |
| | Masahiro Tanaka | sp | 27 | 30 | 27 | 30 |
| | Nathan Eovaldi | sp | 24 | 27 | 24 | 27 |
| | Mitch Keller | sp | 14 | 17 | 14 | 17 |
| f | Jake Odorizzi | sp | 11 | 9 | 11 | 9 |
| | Tejay Antone | mr | 35 | 33 | 11 | 14 |
| | Cal Quantrill | mr | 49 | 43 | 8 | 1 |
| | Alex Reyes | mr | 42 | 37 | 3 | 1 |
| f | Freddy Peralta | mr | 41 | 33 | 3 | 4 |
| | Kyle Zimmer | mr | 43 | 47 | 3 | 0 |
| f | Mike Montgomery | mr | 8 | 4 | 3 | 3 |
| f | Ben Braymer | mr | 8 | 6 | 3 | 4 |
| | James Hoyt | mr | 65 | 66 | 0 | 0 |
| | Nik Turley | mr | 68 | 53 | 0 | 0 |
| | Ryan Sherriff | mr | 27 | 29 | 0 | 0 |
| f | Ray Black | mr | 8 | 10 | 0 | 0 |
| f | Jordan Hicks | cl | 0 | 0 | 0 | 0 |
| f | David Price | sp | 0 | 0 | 0 | 0 |
| | Blake Taylor | mr | 59 | 55 | 0 | 0 |
| | Anthony Misiewicz | mr | 57 | 40 | 0 | 0 |
| f | Foster Griffin | mr | 3 | 6 | 0 | 0 |
| | Total | | 177 | 162 | 177 | 162 |