League injury log -- American League
Regular season -- as of 10/29/2021
| Injuries |
| Date | # | Team | Player | Cause | Dur |
| 4/15/2021 | | ChW | Quantrill | General | 1 |
| 4/15/2021 | | Min | Tucker,K | General | 1 |
| 4/15/2021 | | Oak | Goldschmidt | General | 1 |
| 4/15/2021 | | LAA | Vazquez | General | 9 |
| 4/16/2021 | | Min | Lopez,N | General | 3 |
| 4/16/2021 | | LAA | Yarbrough | General | 1 |
| 4/16/2021 | | Hou | Murphy,D | General | 19 |
| 4/17/2021 | | Bal | Avila | Hit by pitch | 17 |
| 4/17/2021 | | NYY | Wong | General | 8 |
| 4/17/2021 | | Cle | Sanchez,S | General | 16 |
| 4/17/2021 | | Sea | Happ,I | General | 8 |
| 4/17/2021 | | Sea | Happ,I | General | 1 |
| 4/19/2021 | | Bos | Yastrzemski | General | 1 |
| 4/19/2021 | | Sea | Rodriguez,R | General | 16 |
| 4/19/2021 | | Tex | Smith,K | General | 1 |
| 4/20/2021 | | Bal | Walsh | General | 3 |
| 4/21/2021 | | Tor | Brewer | General | 1 |
| 4/21/2021 | | Det | Chirinos,R | General | 8 |
| 4/21/2021 | | ChW | Misiewicz | General | 4 |
| 4/21/2021 | | Cle | Seager,K | General | 1 |
| 4/21/2021 | | Min | Swanson,D | General | 1 |
| 4/21/2021 | | Oak | Perez,O | General | 3 |
| 4/21/2021 | | Tex | Whitley | General | 1 |
| 4/22/2021 | | Min | Bregman | General | 1 |
| 4/23/2021 | | KC | Lindblom | General | 1 |
| 4/23/2021 | | Tex | Blewett | General | 13 |
| 4/23/2021 | | Hou | Cano | General | 6 |
| 4/24/2021 | | Bal | Urias,J | General | 16 |
| 4/24/2021 | | ChW | Eovaldi | General | 36 |
| 4/24/2021 | | ChW | Hoyt | General | 19 |
| 4/24/2021 | | Hou | Harper,B | General | 5 |
| 4/24/2021 | | Tex | Fulmer,M | General | 16 |
| 4/26/2021 | | TB | Newman | General | 1 |
| 4/26/2021 | | NYY | Knizner | General | 4 |
| 4/26/2021 | | LAA | DeJong | General | 9 |
| 4/27/2021 | | Bal | Avila | Hit by pitch | 1 |
| 4/28/2021 | | Bal | Curtiss | General | 17 |
| 4/28/2021 | | Min | Narvaez | General | 3 |
| 5/13/2021 | | Bal | Crawford,JP | General | 1 |
| 5/14/2021 | | Min | Lopez,N | General | 1 |
| 5/15/2021 | | TB | Hoerner | General | 5 |
| 5/15/2021 | | Cle | Arauz | General | 3 |
| 5/15/2021 | | Cle | Smoak | General | 5 |
| 5/15/2021 | | Tex | Fulmer,M | General | 16 |
| 5/17/2021 | | Tor | Perdomo,L | General | 21 |
| 5/17/2021 | | Cle | Urias,R | General | 1 |
| 5/17/2021 | | Min | Lopez,N | General | 1 |
| 5/17/2021 | | Sea | Baez,J | General | 1 |
| 5/18/2021 | | TB | Jimenez,E | General | 1 |
| 5/18/2021 | | Cle | Seager,K | General | 1 |
| 5/18/2021 | | Oak | Thompson | General | 1 |
| 5/21/2021 | | ChW | Diaz,Y | Brawl | 20 |
| 5/21/2021 | | ChW | Taylor,C | General | 6 |
| 5/21/2021 | | Sea | Wisler | General | 1 |
| 5/21/2021 | | Sea | Glasnow | General | 1 |
| 5/22/2021 | | Bos | Javier | General | 11 |
| 5/22/2021 | | NYY | Bundy | General | 1 |
| 5/22/2021 | | Det | Santana,Do | General | 1 |
| 5/22/2021 | | Sea | Happ,I | General | 3 |
| 5/22/2021 | | Tex | Crawford,B | General | 1 |
| 5/23/2021 | | Cle | Mercer | General | 6 |
| 5/23/2021 | | Sea | Skubal | General | 16 |
| 5/23/2021 | | Hou | Grossman | General | 16 |
| 5/24/2021 | | Bos | Yastrzemski | General | 11 |
| 5/24/2021 | | ChW | McNeil | General | 7 |
| 5/24/2021 | | Sea | Rodriguez,R | General | 17 |
| 5/24/2021 | | Tex | Quinn | General | 1 |
| 5/25/2021 | | TB | Wright | General | 6 |
| 5/25/2021 | | Cle | Ravelo | General | 6 |
| 5/25/2021 | | Min | Hays | General | 11 |
| 5/28/2021 | | Tor | Kintzler | General | 1 |
| 5/28/2021 | | LAA | Beaty | Hit by pitch | 1 |
| 5/28/2021 | | Sea | Baez,J | General | 1 |
| 5/28/2021 | | Tex | Taveras | General | 1 |
| 5/28/2021 | | Hou | Dubon | General | 7 |
| 5/29/2021 | | ChW | McNeil | General | 8 |
| 5/29/2021 | | Cle | Jansen,D | General | 1 |
| 5/29/2021 | | Hou | Murphy,D | General | 2 |
| 5/30/2021 | | TB | Collins | Hit by pitch | 1 |
| 5/30/2021 | | TB | DeShields | General | 6 |
| 5/30/2021 | | Oak | Garneau | General | 2 |
| 6/14/2021 | | ChW | Hicks | General | 1 |
| 6/14/2021 | | TB | Hoerner | General | 6 |
| 6/15/2021 | | ChW | Taylor,C | General | 3 |
| 6/17/2021 | | Bal | Crawford,JP | General | 1 |
| 6/17/2021 | | Sea | La Stella | General | 6 |
| 6/17/2021 | | Tor | Velasquez | General | 6 |
| 6/17/2021 | | KC | Ramirez,Y | General | 12 |
| 6/18/2021 | | LAA | Pineda | General | 1 |
| 6/19/2021 | | Bal | Longoria | General | 19 |
| 6/19/2021 | | Bos | Ruf | General | 1 |
| 6/19/2021 | | Sea | LeMahieu | Hit by pitch | 1 |
| 6/21/2021 | | Sea | Happ,I | General | 4 |
| 6/21/2021 | | ChW | Diaz,Y | General | 24 |
| 6/21/2021 | | Oak | McCutchen | General | 3 |
| 6/21/2021 | | Det | Chirinos,R | General | 1 |
| 6/22/2021 | | Bal | Curtiss | General | 1 |
| 6/22/2021 | | Bos | Hudson,Dak | General | 6 |
| 6/22/2021 | | ChW | Fisher | General | 13 |
| 6/22/2021 | | KC | Meadows | Hit by pitch | 21 |
| 6/22/2021 | | KC | Villar | Hit by pitch | 11 |
| 6/23/2021 | | NYY | May,D | General | 1 |
| 6/23/2021 | | Cle | Hoskins | General | 1 |
| 6/23/2021 | | Min | Freeman,F | General | 1 |
| 6/23/2021 | | Cle | Roe | General | 1 |
| 6/24/2021 | | Sea | Alonso | Hit by pitch | 9 |
| 6/24/2021 | | Cle | Weber | General | 1 |
| 6/25/2021 | | TB | Eaton | General | 6 |
| 6/25/2021 | | Hou | Murphy,D | General | 1 |
| 6/26/2021 | | KC | Segura | General | 2 |
| 6/26/2021 | | Hou | Bryant | Hit by pitch | 26 |
| 6/26/2021 | | Det | Cody | General | 16 |
| 6/26/2021 | | Oak | Kuhl | General | 1 |
| 6/28/2021 | | Sea | Merrifield | General | 1 |
| 6/28/2021 | | Bos | Arraez | General | 15 |
| 6/28/2021 | | Tor | Judge | Hit by pitch | 1 |
| 6/28/2021 | | Cle | Arauz | General | 1 |
| 6/28/2021 | | Det | Baragar | General | 10 |
| 6/29/2021 | | Cle | Bielak | General | 16 |
| 6/30/2021 | | Bal | Hayes | General | 5 |
| 6/30/2021 | | TB | Franco | General | 1 |
| 6/30/2021 | | Hou | Ponce de Leon | General | 11 |
| 6/30/2021 | | Min | Verdugo | General | 3 |
| 7/15/2021 | | Bal | Hernandez,T | General | 5 |
| 7/15/2021 | | Tor | Semien | General | 4 |
| 7/15/2021 | | TB | Solak | General | 3 |
| 7/15/2021 | | TB | Newman | General | 18 |
| 7/16/2021 | | Bal | Ward | General | 8 |
| 7/16/2021 | | NYY | Knizner | General | 18 |
| 7/16/2021 | | Det | Blackmon | General | 1 |
| 7/16/2021 | | Det | Turner,J | Hit by pitch | 17 |
| 7/17/2021 | | Det | Sims | General | 14 |
| 7/17/2021 | | LAA | Bumgarner | General | 1 |
| 7/17/2021 | | Tex | Crawford,B | Hit by pitch | 17 |
| 7/19/2021 | | Det | Blackmon | General | 1 |
| 7/19/2021 | | LAA | Morgan | General | 3 |
| 7/20/2021 | | Bal | Higashioka | Hit by pitch | 35 |
| 7/20/2021 | | TB | Eaton | General | 2 |
| 7/20/2021 | | TB | Newman | General | 1 |
| 7/20/2021 | | Min | Lopez,N | General | 2 |
| 7/21/2021 | | Bal | Higashioka | General | 48 |
| 7/21/2021 | | Bos | Merryweather | General | 16 |
| 7/21/2021 | | TB | Smeltzer | General | 1 |
| 7/21/2021 | | ChW | Rizzo | Hit by pitch | 6 |
| 7/21/2021 | | Cle | Bichette | General | 6 |
| 7/21/2021 | | Min | Tucker,K | General | 1 |
| 7/21/2021 | | LAA | Suarez,E | General | 2 |
| 7/21/2021 | | Sea | Dickerson,A | General | 9 |
| 7/21/2021 | | Sea | Merrifield | General | 1 |
| 7/22/2021 | | Bos | Grossman | General | 2 |
| 7/22/2021 | | NYY | Springer | General | 3 |
| 7/22/2021 | | KC | Phegley | Hit by pitch | 1 |
| 7/22/2021 | | Sea | Keller,B | General | 1 |
| 7/23/2021 | | TB | Springs | General | 6 |
| 7/24/2021 | | ChW | Hicks | General | 4 |
| 7/24/2021 | | Oak | Anderson,Ty | General | 11 |
| 7/24/2021 | | Tex | Hernandez,J | General | 1 |
| 7/26/2021 | | Bal | Urias,J | General | 6 |
| 7/26/2021 | | Bos | Kim | General | 11 |
| 7/26/2021 | | Cle | Houck | General | 1 |
| 7/26/2021 | | Hou | Stammen | General | 1 |
| 7/27/2021 | | Tor | Tepera | General | 1 |
| 7/27/2021 | | Bos | Davis,JD | General | 3 |
| 7/27/2021 | | Bos | Plutko | Brawl | 39 |
| 7/27/2021 | | TB | Robles,V | Hit by pitch | 23 |
| 7/27/2021 | | Min | Narvaez | General | 1 |
| 7/27/2021 | | Hou | Bryant | General | 22 |
| 7/27/2021 | | Hou | Stassi | General | 1 |
| 7/28/2021 | | Tor | Panik | General | 4 |
| 7/28/2021 | | Bos | Chavis | General | 9 |
| 7/28/2021 | | NYY | Knizner | General | 7 |
| 7/28/2021 | | Sea | Fedde | General | 16 |
| 8/13/2021 | | Min | Riley | General | 3 |
| 8/13/2021 | | NYY | Thomas | General | 5 |
| 8/13/2021 | | KC | Howard,Sa | General | 1 |
| 8/13/2021 | | Tex | Harrison,M | General | 1 |
| 8/13/2021 | | Min | Reid-Foley | General | 1 |
| 8/14/2021 | | Bos | Perez,S | General | 1 |
| 8/14/2021 | | ChW | Rizzo | General | 1 |
| 8/14/2021 | | TB | Escobar | General | 1 |
| 8/14/2021 | | Oak | Anderson,Ty | General | 16 |
| 8/15/2021 | | Sea | La Stella | General | 4 |
| 8/15/2021 | | ChW | Rizzo | Hit by pitch | 6 |
| 8/15/2021 | | Tor | Suzuki | Hit by pitch | 19 |
| 8/15/2021 | | Det | Harris | General | 1 |
| 8/16/2021 | | Bal | Kemp,T | General | 1 |
| 8/17/2021 | | Bos | Pinder | Hit by pitch | 5 |
| 8/17/2021 | | TB | Jimenez,E | General | 6 |
| 8/17/2021 | | KC | Lindblom | General | 16 |
| 8/17/2021 | | Tor | Suzuki | General | 6 |
| 8/17/2021 | | Det | Kittredge | General | 1 |
| 8/18/2021 | | Bal | Hernandez,T | General | 26 |
| 8/18/2021 | | Min | Tucker,K | General | 5 |
| 8/18/2021 | | NYY | Buxton | General | 1 |
| 8/18/2021 | | TB | Newman | General | 1 |
| 8/20/2021 | | Cle | Bielak | General | 1 |
| 8/20/2021 | | Tor | Contreras,WE | General | 1 |
| 8/20/2021 | | KC | Jones,JaC | General | 1 |
| 8/21/2021 | | Hou | Murphy,D | General | 3 |
| 8/21/2021 | | Cle | Dyson | General | 3 |
| 8/21/2021 | | TB | Eaton | General | 15 |
| 8/22/2021 | | Min | Smith,WM | General | 24 |
| 8/22/2021 | | TB | Escobar | General | 6 |
| 8/22/2021 | | Hou | Dunn | General | 1 |
| 8/23/2021 | | KC | Segura | General | 9 |
| 8/25/2021 | | Det | Mateo | General | 24 |
| 8/25/2021 | | Det | Turner,J | General | 10 |
| 8/25/2021 | | ChW | Anderson,Bri | General | 1 |
| 8/25/2021 | | ChW | Tanaka | General | 26 |
| 8/25/2021 | | Oak | Brantley | General | 1 |
| 8/27/2021 | | NYY | Bundy | General | 11 |
| 8/27/2021 | | Min | Tucker,K | General | 1 |
| 8/27/2021 | | Min | Verdugo | General | 1 |
| 8/28/2021 | | TB | Hoerner | General | 5 |
| 8/28/2021 | | ChW | Montgomery,M | General | 21 |
| 8/29/2021 | | Tex | Wade,T | Hit by pitch | 23 |
| 8/29/2021 | | Tor | Neverauskas | General | 18 |
| 8/29/2021 | | Tor | Contreras,WE | General | 1 |
| 9/13/2021 | | Tex | McKenzie | General | 1 |
| 9/13/2021 | | Tex | McKenzie | General | 6 |
| 9/14/2021 | | Tor | Cole,AJ | General | 1 |
| 9/14/2021 | | Tor | Newcomb | General | 1 |
| 9/15/2021 | | Bal | Mills | General | 11 |
| 9/15/2021 | | Bos | Kaminsky | General | 1 |
| 9/15/2021 | | TB | Jimenez,E | General | 5 |
| 9/15/2021 | | ChW | McNeil | General | 6 |
| 9/15/2021 | | ChW | Torres | General | 3 |
| 9/15/2021 | | Oak | Ervin | General | 3 |
| 9/15/2021 | | Sea | Skubal | General | 16 |
| 9/17/2021 | | KC | Jones,JaC | General | 34 |
| 9/17/2021 | | KC | Arrieta | General | 11 |
| 9/17/2021 | | Tex | Wade,T | General | 1 |
| 9/17/2021 | | Oak | Peralta,D | General | 12 |
| 9/18/2021 | | Bal | Biggio | General | 1 |
| 9/18/2021 | | TB | Jimenez,E | General | 1 |
| 9/19/2021 | | LAA | DeJong | General | 6 |
| 9/20/2021 | | Hou | Dubon | General | 1 |
| 9/20/2021 | | Hou | Oliva | General | 1 |
| 9/21/2021 | | Tor | Velasquez | Brawl | 21 |
| 9/21/2021 | | KC | Huff | General | 6 |
| 9/21/2021 | | Tex | Sanchez,An | General | 16 |
| 9/22/2021 | | TB | Canning | General | 16 |
| 9/22/2021 | | Det | Turner,J | General | 13 |
| 9/22/2021 | | Sea | Castro,M | General | 1 |
| 9/22/2021 | | Tex | Rosario,E | General | 1 |
| 9/24/2021 | | TB | Hoerner | General | 3 |
| 9/24/2021 | | Tor | Reyes,F | General | 1 |
| 9/24/2021 | | Cle | Sanchez,S | General | 6 |
| 9/24/2021 | | Det | Garcia,LV | General | 8 |
| 9/24/2021 | | Tex | Elledge | General | 5 |
| 9/24/2021 | | Hou | Dunn | General | 11 |
| 9/25/2021 | | Det | Mateo | Hit by pitch | 13 |
| 9/26/2021 | | KC | Alberto | General | 15 |
| 9/26/2021 | | Det | Davis,Jo | Hit by pitch | 8 |
| 9/26/2021 | | Hou | Verlander | General | 1 |
| 10/2/2021 | | Det | Santana,Do | General | 5 |
| 10/13/2021 | | Sea | Arroyo | General | 1 |
| 10/15/2021 | | Bal | Longoria | General | 1 |