League team vs team - 2021 American League
Regular season
| American League |
| Tor | Bal | TB | Bos | NYY | Cle | KC | Det | Min | ChW | LAA | Hou | Oak | Sea | Tex |
| Tor | x | 3-15 | 14-4 | 2-16 | 11-7 | 5-1 | 3-3 | 1-5 | 1-5 | 1-5 | 1-5 | 1-5 | 2-4 | 1-5 | 4-2 |
| Bal | 15-3 | x | 17-1 | 10-9 | 11-7 | 6-0 | 6-0 | 2-4 | 4-2 | 3-3 | 4-2 | 5-1 | 5-1 | 4-2 | 6-0 |
| TB | 4-14 | 1-17 | x | 1-17 | 1-17 | 2-4 | 2-4 | 1-5 | 3-3 | 0-6 | 2-4 | 2-4 | 3-3 | 0-6 | 1-5 |
| Bos | 16-2 | 9-10 | 17-1 | x | 6-12 | 6-0 | 5-1 | 3-3 | 5-1 | 5-1 | 3-3 | 4-2 | 3-3 | 2-4 | 5-1 |
| NYY | 7-11 | 7-11 | 17-1 | 12-6 | x | 6-0 | 4-2 | 4-2 | 3-3 | 5-1 | 0-6 | 2-4 | 5-1 | 2-4 | 5-1 |
| | | | | | | | | | | | | | | | |
| Cle | 1-5 | 0-6 | 4-2 | 0-6 | 0-6 | x | 6-12 | 5-13 | 4-14 | 3-15 | 2-4 | 3-3 | 1-5 | 0-6 | 5-1 |
| KC | 3-3 | 0-6 | 4-2 | 1-5 | 2-4 | 12-6 | x | 3-15 | 8-10 | 3-15 | 2-4 | 3-3 | 3-3 | 2-4 | 6-0 |
| Det | 5-1 | 4-2 | 5-1 | 3-3 | 2-4 | 13-5 | 15-3 | x | 11-7 | 7-11 | 4-2 | 6-0 | 4-2 | 4-2 | 6-0 |
| Min | 5-1 | 2-4 | 3-3 | 1-5 | 3-3 | 14-4 | 10-8 | 7-11 | x | 5-13 | 1-5 | 5-1 | 4-2 | 1-5 | 4-2 |
| ChW | 5-1 | 3-3 | 6-0 | 1-5 | 1-5 | 15-3 | 15-3 | 11-7 | 13-5 | x | 4-2 | 4-2 | 4-2 | 5-1 | 5-1 |
| | | | | | | | | | | | | | | | |
| LAA | 5-1 | 2-4 | 4-2 | 3-3 | 6-0 | 4-2 | 4-2 | 2-4 | 5-1 | 2-4 | x | 13-5 | 10-8 | 9-9 | 11-7 |
| Hou | 5-1 | 1-5 | 4-2 | 2-4 | 4-2 | 3-3 | 3-3 | 0-6 | 1-5 | 2-4 | 5-13 | x | 7-11 | 3-15 | 8-10 |
| Oak | 4-2 | 1-5 | 3-3 | 3-3 | 1-5 | 5-1 | 3-3 | 2-4 | 2-4 | 2-4 | 8-10 | 11-7 | x | 8-10 | 13-5 |
| Sea | 5-1 | 2-4 | 6-0 | 4-2 | 4-2 | 6-0 | 4-2 | 2-4 | 5-1 | 1-5 | 9-9 | 15-3 | 10-8 | x | 14-4 |
| Tex | 2-4 | 0-6 | 5-1 | 1-5 | 1-5 | 1-5 | 0-6 | 0-6 | 2-4 | 1-5 | 7-11 | 10-8 | 5-13 | 4-14 | x |
| | | | | | | | | | | | | | | | |