League team vs team - 2008 American League
Regular season
| American League |
| Tor | Tam | Bal | Bos | NYY | Cle | KC | Det | Min | ChW | LAA | Oak | Sea | Tex |
| Tor | x | 3-11 | 9-4 | 7-7 | 10-3 | 2-10 | 6-6 | 4-8 | 4-8 | 3-9 | 9-3 | 4-8 | 3-9 | 7-5 |
| Tam | 11-3 | x | 10-4 | 10-3 | 9-4 | 4-8 | 8-4 | 3-9 | 6-6 | 6-6 | 3-9 | 7-5 | 4-8 | 6-6 |
| Bal | 4-9 | 4-10 | x | 7-6 | 11-3 | 3-9 | 7-5 | 2-10 | 2-10 | 4-8 | 2-10 | 6-6 | 6-6 | 6-6 |
| Bos | 7-7 | 3-10 | 6-7 | x | 10-4 | 4-8 | 4-8 | 4-8 | 3-9 | 3-9 | 6-6 | 8-4 | 4-8 | 8-4 |
| NYY | 3-10 | 4-9 | 3-11 | 4-10 | x | 1-11 | 8-4 | 2-10 | 2-10 | 4-8 | 2-10 | 6-6 | 3-9 | 4-8 |
| | | | | | | | | | | | | | | |
| Cle | 10-2 | 8-4 | 9-3 | 8-4 | 11-1 | x | 10-3 | 4-10 | 7-6 | 12-2 | 6-6 | 9-3 | 6-6 | 9-3 |
| KC | 6-6 | 4-8 | 5-7 | 8-4 | 4-8 | 3-10 | x | 4-9 | 4-10 | 2-12 | 5-7 | 2-10 | 2-10 | 3-9 |
| Det | 8-4 | 9-3 | 10-2 | 8-4 | 10-2 | 10-4 | 9-4 | x | 8-6 | 5-8 | 8-4 | 8-4 | 4-8 | 9-3 |
| Min | 8-4 | 6-6 | 10-2 | 9-3 | 10-2 | 6-7 | 10-4 | 6-8 | x | 4-9 | 6-6 | 8-4 | 3-9 | 10-2 |
| ChW | 9-3 | 6-6 | 8-4 | 9-3 | 8-4 | 2-12 | 12-2 | 8-5 | 9-4 | x | 8-4 | 8-4 | 5-7 | 7-5 |
| | | | | | | | | | | | | | | |
| LAA | 3-9 | 9-3 | 10-2 | 6-6 | 10-2 | 6-6 | 7-5 | 4-8 | 6-6 | 4-8 | x | 8-6 | 3-11 | 10-4 |
| Oak | 8-4 | 5-7 | 6-6 | 4-8 | 6-6 | 3-9 | 10-2 | 4-8 | 4-8 | 4-8 | 6-8 | x | 4-10 | 6-8 |
| Sea | 9-3 | 8-4 | 6-6 | 8-4 | 9-3 | 6-6 | 10-2 | 8-4 | 9-3 | 7-5 | 11-3 | 10-4 | x | 12-2 |
| Tex | 5-7 | 6-6 | 6-6 | 4-8 | 8-4 | 3-9 | 9-3 | 3-9 | 2-10 | 5-7 | 4-10 | 8-6 | 2-12 | x |
| | | | | | | | | | | | | | | |